Idh2 gene
Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia
... and IDH2 genes in AML are re- ported as being associated to diverse outcomes by differ- ent groups ...IDH1 gene as a new recurrent mutation associated with ...the IDH2 gene (R140 and R172) in ...
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<p>Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma</p>
... the IDH2 gene at position R172 was fi rst discovered in patients with gliomas, including astrocytomas and ...date, IDH2 mutants have been detected in several ...on IDH2 has primarily focused on ...
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Study of Isocitrate Dehydrogenase 1and 2 Mutations in Adult Egyptian Patients with Denovo Acute Myeloblastic Leukemia, Their Relation to Clinical Characteristics, FLT3/ITD and Nucleophosmin 1 Mutations and Impact on Treatment Outcome
... for IDH2 (R140Q), and 1 min at 60°C for IDH2 (R172K), elongation for 45 s at 72°C and a final extension of 5 min was carried out at ...normal IDH2 gene product, was produced from WT ...
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<p>Detection Of Mutations In The Isocitrate Dehydrogenase Genes (IDH1/IDH2) Using castPCR<sup>TM</sup> In Patients With AML And Their Clinical Impact In Mexico City</p>
... IDH1 gene mutations have been reported to be less common than IDH2 mutations in ...the IDH2 gene, the mutations detected included R172K and ...of IDH2 mutations in AML, we found a ...
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Genetic and Biochemical Interactions Involving Tricarboxylic Acid Cycle (TCA) Function Using a Collection of Mutants Defective in All TCA Cycle Genes
... the IDH2 gene encoding the Idh2p subunit of the NAD 1 -dependent isocitrate dehydrogenase ...nonsense idh2 mutants grow poorly on glycerol, but growth can be enhanced by extragenic mutations, termed ...
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Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
... regarding IDH2 expression in cancers, a search for the IDH2 gene was conducted in several databases containing more than 1,000 tumor ...the IDH2 gene and was found in ...33]. ...
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Maffucci syndrome and neoplasms: a case report and review of the literature
... from peripheral blood. We analyzed the 10 coding exons of the IDH1 gene by Sanger sequencing and detected the mutation c.394C > T (p.Arg132Cys) in exon 4 of IDH1 in the heterozygous state. This mutation leading ...
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Case Report Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma
... well-characterized, gene expression profiling has proposed the cell of origin as follicular helper T-cells, which may explain the observed immunosuppressive effects due to T-cell ...
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Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients
... whereas IDH2 and IDH3 are localized in the mitochon- dria [9,10]. IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate into a- ketoglutarate (a-KG) by utilizing ...
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Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry
... Fresh frozen tumor tissues from 54 patients with predeter- mined IDH status were selected from the archive of the Department of Neuropathology, Heidelberg. Of those, 26 tumor tissues carried either an IDH1 or an ...
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Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance
... (MLL) gene in AML [60, 61], and its oncogenic relevance depends more on its capacity to bind DNA and recruit other pro- teins than its enzymatic activity [15, ...
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Evaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy
... with IDH2-mutated AML were presented, who developed resistance to the mutant IDH2 inhibitor enasidenib as a result of second-site IDH2 mutations (Q316E, I319M) in the wild-type allele (in trans), ...
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Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status
... , IDH2 R172S , IDH1 R132L , and IDH1 R132S ...or IDH2 (collectively referred to as IDH) cause alterations in cell metabolism, cell growth signalling pathways, and the DNA damage response ...
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Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
... (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle, which can catalyze the conversion of isocitrate to α-ketoglutarate (KG), thus generating nicotinamide adenine dinucleotide ...
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Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations
... We selected and enrolled 51 patients with diagnosed DNMT3A-mutated AML from The Cancer Genome Atlas (TCGA) database (https://cancergenome.nih.gov/). We col- lected data including age, gender, AML French-American- British ...
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Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes
... mutant IDH1 using AGI-5198 did not lead to any changes in radiosensitivity, nor in altered GSH levels. Also, no dif- ference was observed in γ-H2AX foci formation between IDH mutant and IDH wild type chondrosarcoma ...
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From pattern to gene, from gene to pattern
... pair-rule gene mutants in Drosophila was wholly unexpected because it revealed that the establishment of the overt segmental periodicity of the larva proceeded through an intermediate, morphologically invis- ible, ...
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Gene-carried hepatoma targeting complex induced high gene transfection efficiency with low toxicity and significant antitumor activity
... magnetic resonance spectroscopy and ultraviolet spectrophotometry. The particle size of CPT/ DNA complexes was measured using laser diffraction spectrometry and the cytotoxicity of the copolymer was evaluated by ...
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Isolation and Characterization Of Novel Egyptian Regulatory Gene Tri 10 From Fusarium fujikuroi (MG211161)
... 10 gene (MG674224) with of Gibberella pulicaris ...10) gene, complete cds, Fusarium sporotrichioides ...trichothecene gene and Fusarium sp ...our gene sharing 70 % identity of the consensus ...
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Dynamics and Heterogeneity of Gene Expression and Epigenetic Regulation at the Single-Cell Level
... There are two types of characterized mechanisms that can mediate gene regulation down- stream of chromatin modifications. The first type involves disrupting the contacts between different histones in neighboring ...
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