IFN-γ receptor
In a novel form of IFN γ receptor 1 deficiency, cell surface receptors fail to bind IFN γ
... Complete IFN-γ receptor ligand-binding chain (IFNγR1) deficiency is a life-threatening autosomal recessive immune disorder. Affected children invariably die of mycobacterial infection, unless bone ...
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Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I
... supported by our results, which fail to show an important role for IL-18 in IFN- ␥ production in response to the influenza virus vaccine. One explanation for this discrepancy might be that vaccination with ...
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Gamma Interferon (IFN-γ) Receptor Restricts Systemic Dengue Virus Replication and Prevents Paralysis in IFN-α/β Receptor-Deficient Mice
... the IFN- ␥ R alone and virtually no mice lacking the IFN-␣/R alone develop ...the IFN-␣/R, signaling through the IFN-␥R confers approximately 140-fold greater resis- tance against systemic ...
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Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice
... ever, IFN-g is currently better known for the remarkable spec- trum of pleiotropic effects it elicits in diverse tissues and par- ticularly for its unique immunoregulatory properties which distinguish it from ...
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Collagen induced arthritis is exacerbated in IL 10 deficient mice
... by IFN- γ , the role of IFN- γ in the pathogenesis of CIA is not clearly ...understood. IFN-γ appears to have two separate functions, disease promoting as well as disease ...
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Molecular Characterization, 3D Modeling of Grass Carp Interleukin 10 Receptor 1 (IL10R1)
... chicken IFN-γ receptor alpha chain (PDB id: 4EQ3) and human IFN-γ receptor alpha chain (PDB id: 3S8W) as ...chicken IFN-γ receptor alpha ...
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Psychological stress suppresses innate IFN gamma production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide
... innate IFN- γγγγ response in vivo: In the present study we demonstrate that restraint stress suppresses innate IFN-γ production induced following an in vivo challenge with bacterial ...increased ...
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Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis
... of IFN-γ receptor in the tumor cells per ...implicate IFN-γ signaling as an important player in the regulation of tumor ...of IFN-γ receptor on non-hematopoietic ...
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Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?
... with eosinophils or airway hyperresponsiveness [9]. However, no study was found related to specific Th1- mediated response to a mite antigen as D. pteronyssinus. We also found that in addition to IFN-γ, ...
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Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates
... plus IFN-γ, complete DMEM-10 plus IFN-γ and indole, and complete DMEM-10 plus IFN- γ and excess ...of IFN- γ , suggesting that there is induction of expression ...
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T cell–mediated vascular dysfunction of human allografts results from IFN γ dysregulation of NO synthase
... Neutralizing IFN-γ completely prevented both vascular dysfunction and changes in NOS expression; neutralizing TNF reduced IFN-γ production and partially prevented ...
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Individual T helper cells have a quantitative cytokine memory
... of IFN-γ secretion had more T-bet mRNA and protein than their IFN-γ lo and IFN-γ – counterparts ...of IFN-γ lo and IFN-γ – cells at the Tbx21 locus ...
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Immune Responses of CD4 + T-Cells of MDR-TB Patients to M.Tuberculosis Total Lipid Antigens
... of IFN- γ production in MDR-TB and TB patients is not due to the increase of IL-10 ...of IFN-γ down regulation in CD4 + T cells of TB and MDR-TB ...
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... of IFN-γ and the frequency of circulating CD8+IFN-γ+ T cells in the blood of patients is found to correlate with psoriasis disease severity ...of IFN-γ is found to be ...
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Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study
... To provide more supporting evidence, we assessed the intrathecal CSF profile of a subgroup of patients with and without OCB. Our results confirmed that OCB+ patients have a greater intrathecal inflamma- tory activity ...
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Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy
... For RNA sequencing (RNA-Seq), THP-1 control and TET2-KO cells were treated with or without IFN-γ for 20 hours, and total RNA was isolated. Each condition was prepared in triplicate for each RNA- Seq ...
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Exposure to receptor activator of NFκB ligand renders pre osteoclasts resistant to IFN γ by inducing terminal differentiation
... with IFN- γ for 5, 15 and 60 min, and then protein extracts were analyzed by immunoblotting as described in Materials and ...with IFN- γ ...the receptor-activator of NF κ B ligand ...
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Histamine receptor H1 is required for TCR mediated p38 MAPK activation and optimal IFN γ production in mice
... cells were activated with anti-CD3 and anti-CD28 mAbs in the presence of IL-12 (4 ng/ml) and anti-IL-4 mAb (10 μ g/ml). After 4 days, cells were restimulated and IFN-γ production was determined. F = 25.4, P ...
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Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis
... sis patients versus controls and decreased mRNA expres- sion of TIM-1 in non-Löfgren's patiens versus Löfgren's patients (figure 6) [33]. Further studies on human TIM-3 polymorphisms and function in sarcoidosis may ...
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Role of CCR5 in IFN γ–induced and cigarette smoke–induced emphysema
... of IFN-g–induced inflammation and remodeling in a murine emphysema ...model. IFN-g was a potent stimula- tor of the CCR5 ligands macrophage inflammatory protein–1α/CCL-3 (MIP-1α/CCL-3), MIP-1β/CCL-4, and ...
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