IFN-stimulated gene expression
Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET
... of IFN-stimulated genes has been suggested as a pos- sible method for assessing embryo survival as well as for early detection of pregnancy ...of IFN-stimulated gene expression ...
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Cytomegalovirus InducesInterferon-Stimulated Gene Expression and Is Attenuated by Interferon in the Developing Brain
... (IFN)-stimulated gene expression by 10- to 100-fold in both glia- and neuron-enriched ...with IFN- ␣ , -  , and - ␥ or a synthetic RNA, poly(I:C), reduced the number of mCMV-infected ...
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Differential Expression of Interferon (IFN) Regulatory Factors and IFN-Stimulated Genes at Early Times after West Nile Virus Infection of Mouse Embryo Fibroblasts
... by IFN treatment but were activated to less than twofold in WNV- infected cells by 12 h (Table 3 and ...Socs3 gene ex- pression was induced by IFN treatment but not at 12 h after WNV infection ...I ...
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Inhibition of IL 12 production by 1,25 dihydroxyvitamin D3 Involvement of NF kappaB downregulation in transcriptional repression of the p40 gene
... promoter stimulated with IFN- g and ...the expression of multiple genes which are subject to regulation by NF- k ...the expression of the inhibitor I k B a (62, ...
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Differential human multiple myeloma cell line responsiveness to interferon alpha Analysis of transcription factor activation and interleukin 6 receptor expression
... after IFN-a stimula- ...cytokines stimulated the activation and nuclear translocation of Stat 3 into the nucleus, it may be seen in the third panel in ...and IFN- a stim- ulated the tyrosine ...
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Inhibitory Effect of Gamma Interferon on BK Virus Gene Expression and Replication
... the IFN- ␥ signaling cascade as a result of IFN- ␥ binding to the surface receptor has a multitude of effects on the cell (reviewed in references 37 and ...38). IFN- ␥ has overall antiproliferative ...
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Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN α–stimulated STAT2 independent production of IFN γ in the brain
... Shh gene expression. Our studies identified one factor, IFN-γ, as the most likely candidate, since this cytokine was capable of inducing Shh gene expression by cultured cerebellar ...
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Type 1 and type 2 cytokine gene expression by viral gp135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection.
... examined IFN-g and IL-4 gene expression in CAEV SU-stimulated PBMC from selected CAEV-63- and CAEV-Co-infected goats at 59 months ...of IFN-g mRNA (lanes 1, 3, 5, 7, and 9), IL-4 mRNA ...
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Viral Evolution and Interferon Resistance of Hepatitis C Virus RNA Replication in a Cell Culture Model
... the expression of alpha-beta interferons (IFN-␣/) and IFN-stimulated genes (ISGs) ...the IFN regulatory factors (IRFs) and NF-B transcription factors (27, 38, 45, ...the ...
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Basal and Reovirus-Induced Beta Interferon (IFN-β) and IFN-β-Stimulated Gene Expression Are Cell Type Specific in the Cardiac Protective Response
... IRF-7 expression is higher in PCMCs than in PCFCs, but reovirus induction of IRF-7 is ...induced expression of IFN-  was greater in PCMCs than in PCFCs; thus, we inquired whether basal and/or ...
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A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus
... TLR9-stimulated IFN-α, with >90% neutralization at doses ≥10 ...reduced IFN-α more potently, with com- plete inhibition at equivalent doses (Figure ...neutralized IFN-α, these had minimal ...
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The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration
... Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteogly- cans and collagens in articular cartilage [29,32-34], as well as bovine IVD cells in vitro [30]. The present ...
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Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis
... for IFN-  and CCL2/MCP-1 were 40 cycles consisting of denaturation at 95°C for 10 s, annealing at 65°C for 5 s, and extension at 72°C for 11 s, with acquisition at ...
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Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism
... blocking IFN signaling ...inhibit IFN- ␣ signaling ...of IFN signaling during ...inhibiting IFN- ␣ signaling ...an IFN antagonist ...its IFN antagonism ...an IFN ...
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Activation of type I interferon antiviral response in human neural stem cells
... produce IFN-β (type I) and λ1 (type III) upon transfection with poly(I:C), which is a synthetic analog of double-stranded RNA for mimicking viral ...However, IFN-α mRNA was not significantly induced in the ...
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A role for type 111 interferons in the natural killer cell immune response to virus
... IFN stimulated gene IFN stimulated gene factor IFN stimulated response elements Immunoreceptor tyrosine-based inhibitory motif Janus kinase Killer immunoglobulin -like receptor Lymphokin[r] ...
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Murine Gammaherpesvirus 68 Has Evolved Gamma Interferon and Stat1-Repressible Promoters for the Lytic Switch Gene 50
... viral gene expression with important consequences for viral replication and ...the IFN- ␥ -mediated control of ␥ HV68 reactivation; however, the molecular mechanism of this IFN- ␥ action is ...
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Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Mice
... HBV gene expression and replication can be inhibited by hepatocyto- tropic DNA viruses, like HBV, providing additional support to the notion that similar antiviral events can limit HBV infection during ...
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Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... The present results reveal that the expression of ChemR23 on RA FLSs and chemerin itself activate FLSs to enhance the production of IL-6 and CCL2. IL-6 is considered to have pleiotropic functions, including the ...
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Restoration of TLR3-Activated Myeloid Dendritic Cell Activity Leads to Improved Natural Killer Cell Function in Chronic Hepatitis B Virus Infection
... Expression of intracellular and cell surface molecules on mDC and isolated NK cells determined by flow cytometry. Peripheral blood mononuclear cells (PBMC) were obtained by Ficoll-Isopaque (GE Healthcare, Finland) ...
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