IgG glycosylation
Structure and expression of the beta1, 4-galactosyltransferase gene in relation to IgG glycosylation
... the glycosylation event (Dwek 1995, Goochee and Monica ...hinder glycosylation (Opdenakker 1993). The complexity of the glycosylation process is only fully understood when the interactions between ...
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Immunoglobulin G galactosylation and sialylation are associated with pregnancy induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study
... (Fab) glycosylation separately and its accuracy was ...in IgG glycosylation in detail (galactosylation, sialylation and the presence of the bisecting GlcNAc) in a large cohort of 148 RA-patients and ...
10
Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
... sex-related IgG glycosylation effects in healthy children between 3 months and 17 years (31), the boys and girls in the present study were not assessed ...own IgG molecules, the Fc fucosylation is ...
13
Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
... sex-related IgG glycosylation effects in healthy children between 3 months and 17 years (31), the boys and girls in the present study were not assessed ...own IgG molecules, the Fc fucosylation is ...
13
Estrogens regulate glycosylation of IgG in women and men
... in IgG glycosylation (in particular sialylation) in the ability of murine IgG to induce experimental arthritis, corresponding to lower levels of sialylation and galactosylation in both total and ...
10
Glycosylation analysis of immunoglobulin G : method development and clinical applications
... The IgG glycosylation analysis methods described in Chapter 2 and Chapter 4 of this thesis are robust, can handle large sample cohorts, reveal glycosylation features such as galactosylation, ...
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Canine Distemper Viruses Expressing a Hemagglutinin without N-Glycans Lose Virulence but Retain Immunosuppression
... N glycosylation during vaccine attenu- ation? The morbillivirus vaccine strains currently in use were produced decades ago by serial passage through various cell lines and eggs (11, ...
9
N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for Potency Testing and Immune Processing
... overall glycosylation patterns of all three preparations were weighted toward high-mannose glycans, including paucimannosidic forms on the insect cell-derived ...viral glycosylation antigens were seen, with ...
22
Functional Effects of Coxsackievirus and Adenovirus Receptor Glycosylation on Homophilic Adhesion and Adenoviral Infection
... of glycosylation at N201 results in in- creased ...of glycosylation that may alter coreceptor interactions, improving the efficiency of endocytosis or endosomal ...D2 glycosylation reduces Ad ...
6
Unconventional N Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus
... Immunogold labeling and transmission electron microscopy. Bac- teria were grown overnight on chocolate agar at 37°C and resuspended in PBS to on OD 600 of 0.8. Samples were then fixed using 1% paraformaldy- hde at room ...
9
Covalent Modifications of the Ebola Virus Glycoprotein
... linked glycosylation sites may together play an important role in GP ...linked glycosylation sites near the ectodomain cysteine resi- dues ...N-linked glycosylation site, which is located near the ...
10
Bridging the Gap between Glycosylation and Vesicle Traffic
... Glycan processing at the Golgi apparatus is an essential requirement for numerous cellular functions. Perturbations to the targeted tethering of vesicles that contain glycan modifying enzymes can drastically alter the ...
13
Essential Role of Dengue Virus Envelope Protein N Glycosylation at Asparagine-67 during Viral Propagation
... DV glycosylation mutants propagated in mosquito cells ...E glycosylation for DV replication in mammalian and mosquito cells can be due to differing E se- cretion in the two host cells ...the ...
13
Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG
... complex glycosylation patterns of CSF proteins compared to serum were already described in the 1990s and the term “brain-type glycosylation” was coined for low amounts of terminal sialic acid, elevated ...
18
A mechanism for bistability in glycosylation
... of which to glycosylation has recently appeared [52]. It is known that bistability can arise within noise-driven biochemical systems operating at the level of cellular volume [53], even where it is not predicted ...
15
Hallmarks of glycosylation in cancer
... an unanticipated paradoxical effect to actually aid in tumorigenesis and cancer progression. Within the tumour microenvironment, inflammation can contribute to multiple hallmark capabilities [2, 3], and plays a role in ...
12
Virus-Dependent Glycosylation
... Comparison, after the removal of sialic acid, of the glycopeptides of the major glycoprotein of Prague avian sarcoma virus with the glycopeptides of Sindbis virus grown in transformed ch[r] ...
9
IgG Charge
... data for these mAbs in physiological solvents, and it is not known whether their charge falls into the 43.. range observed for normal human IgGs.[r] ...
14
Fc gamma receptors: Glycobiology and therapeutic prospects
... aglycosylated IgG variants with specific mutations in the Fc region have been shown to bind Fc γ RI with equal or greater affinity than wild-type IgG, presenting an alternative therapeutic strat- ...Various ...
11
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice
... Cell proteins were extracted in sample buffer consisting of 75 mM Tris–HCl, 1% SDS, 2- mercaptoethanol, plus a cocktail of protease inhibitors (Roche). 30µg of soluble proteins were resolved using a NuPage Pre-cast gel ...
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