IL-12-deficient mice
Role of IL 12 in Staphylococcus aureus triggered arthritis and sepsis
... of IL-12 deficiency on decreased survival during S aureus-induced sepsis is the previously described effects of this cytokine on IL-10 ...production. IL-12 induces IL-10 ...
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Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia
... of IL-12 by phagocytic mononuclear cells and dendritic cells is a key component of the molecular networks that induce functional commitment of naïve CD4 T lymphocytes to a Th1 proinflammatory phenotype ...
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Prolonged activation of IL-5–producing ILC2 causes pulmonary arterial hypertrophy
... WT mice were purchased from Japan SLC. IL-5/Venus knock-in mice were generated as previously reported ...Rag2-deficient mice (48) were provided by Frederick ...ΔdblGATA mice (49) ...
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Plasmodium berghei ANKA infection increases Foxp3, IL 10 and IL 2 in CXCL 10 deficient C57BL/6 mice
... During Plasmodium infection, the balance between host pro-inflammatory and anti-inflammatory immune responses play important roles in pathogenesis of CM. A weak pro-inflammatory response may lead to persis- tence and ...
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Accelerated wound healing phenotype in Interleukin 12/23 deficient mice
... Six tissue samples were harvested and pooled for each of IL-12/IL-23p40 -/- and C57BL/6J mice for the follow- ing timepoints: day 0 (unwounded), 2 hours, 1 day, 4 days and 7 days after ...
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IL 12–induced IFN γ is dependent on caspase 1 processing of the IL 18 precursor
... and IL-18 are IFN-γ–inducing ...endogenous IL-18 in the induction of IFN-γ by IL-12 was investigated in ...as IL-1β–converting enzyme, or ICE) IL-12–induced IFN-γ from ...
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Inhibition of airway remodeling in IL 5–deficient mice
... 18–20 mice/group) were genotyped and used in experiments when they reached 8 weeks of ...and IL-5–deficient mice used in this study was C57BL. Mice were immunized intraperi- toneally on ...
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TNF α is crucial for the development of autoimmune arthritis in IL 1 receptor antagonist–deficient mice
... the IL-2 receptor α (CD25), CD69, CD44, CD40 ligand (CD40L; also known as CD154), and OX40 (also known as CD134) (12) CD40L on T cells and its receptor on APCs, as well as OX40 on T cells and its ligand ...
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Collagen induced arthritis is exacerbated in IL 10 deficient mice
... to IL-10 inhibition of IL-12, a differentiation factor for Th1 cells ...by IL-10 [13,14]. In addition, IL-10 stimulates the production of cytokine inhibitors such as IL-1 ...
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IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells
... that IL-10, and not IL-4, was responsible for manipulating monocytes/macrophages in VL infection ...donovani, IL-4, and IL-13 have also been associated with the successful outcome of sodium ...
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IL-3 promotes the development of experimental autoimmune encephalitis
... Heterozygous IL-3–deficient mice were crossbread to obtain WT, heterozy- gous, and homozygous ...to 12-week-old mice were immunized ...2, mice were injected ...Individual ...
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Effector mechanisms of interleukin 17 in collagen induced arthritis in the absence of interferon γ and counteraction by interferon γ
... that IL-17 contributes to the inflammation associated with rheumatoid arthritis ...(RA). IL-17 is spontaneously produced by RA synovial membrane cultures and high levels of IL-17 were detected in the ...
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Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases
... and IL-22, both proinflammatory cytokines capable of promoting local tissue ...of IL-6 and transforming growth factor (TGF)-β, there is an absolute requirement for IL-1 ...In mice ...
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Interleukin-12 p40 secretion by cutaneous CD11c(+) and F4/80(+) cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni
... as IL-1 and ...intracellular IL-12 p40 (FL2) is shown in panel c, and CD45 with an intracellular isotype control is shown in panel ...of IL-12 p40 ⫹ cells on the basis of their size ...
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Original Article Docosahexaenoic acid suppresses pro-inflammatory macrophages and promotes anti-inflammatory/ regulatory macrophage polarization through regulation of cytokines
... phorbol 12-myristate 13-acetate ...in mice. Moreover, DHA decreased M1 cytokines (IL-12 and IFN-γ) and increased M2/Mreg cytokines (IL-4 and IL-10) in ...
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IL 17A and IL 17F do not contribute vitally to autoimmune neuro inflammation in mice
... of IL-17A on CNS inflammation, we generated transgenic mice in which high levels of expression of IL-17A could be initiated after Cre-mediated ...of IL-17A led to skin inflammation and ...
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Experimental autoimmune encephalitis and inflammation in the absence of interleukin 12
... transgenic mice can cause EAE in immunodeficient hosts ...than IL-12 activity is required for the development of ...to IL-12. First, there are p40 homodimers that can be found in ...
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IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation
... of IL-1RA have been shown to correlate with lower risk of worsening asthma con- trol and attacks in adults ...serum IL-1RA may be elevated during acute asthma exacer- bations in a pediatric cohort compared ...
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IL 21 is pivotal in determining age dependent effectiveness of immune responses in a mouse model of human hepatitis B
... HBVEnvRag mice retained a T cell response to 2 peptide pools (Figure ...HBVEnvRag mice reconstituted with adult splenocytes, ELISpot assays also revealed the presence of HBV-specific T cell responses, which ...
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Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE
... The IL-10 KO sham ( n = 4) mouse had several concentrated areas of purple, nucleated cells in the white matter and a loss of most of the blue staining indicating diffuse demyelination ...The IL-10 KO E2 ( n ...
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