IL-5 transgenic mice
Fundamental signals that regulate eosinophil homing to the gastrointestinal tract
... inbred mice of the 129 SvEv strain were maintained with age- and sex-matched controls from Taconic Farms (Germantown, New York, USA) as described ...Swiss mice with matched controls were also obtained from ...
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Chemokine induced eosinophil recruitment Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin
... in agreement with the ability of murine and human MIP-1 a to bind the mCCR3 receptor (41), but not the hCCR3 receptor (12, 13). An alternative explanation for the data, however, is that there is cross-desensitization ...
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Lymph node trafficking and antigen presentation by endobronchial eosinophils
... of mice allowed the transit of these exogenous eosinophils to be ...from IL-5 transgenic mice exhibited identical homing to peritra- cheal lymph nodes (Figures1 and ...normal ...
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Transcriptional profiling of eosinophil subsets in interleukin 5 transgenic mice
... allergy. IL-5 is a critical regulator of eosinophil development, controlling proliferation, differentiation, and maturation of the ...lineage. Mice that constitutively express IL-5 have ...
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Interleukin-18 Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice
... transgenic mice from lineage 1.3.32 were injected simulta- neously with doses of IL-18 ...and IL-12 (1 ng), which were previously determined to not inhibit HBV replication individually (not ...
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Inhibition of airway remodeling in IL 5–deficient mice
... (8). Transgenic mice that have been molecularly engineered to constitutively express IL-5 in the lung epithelium develop accumulation of peribronchial eosinophils, goblet cell hyperplasia, ...
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Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels
... G-CSF, IL-2, IL-3, IL-4, IL-5, IL-9, IL-10, IL-12p70, IL-13, IL-17, and ...(B) Transgenic mice expressing anchorless ...homozygous ...
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Interleukin 15 is required for immunosurveillance and immunoprevention of HER2/neu driven mammary carcinogenesis
... HER2/neu transgenic mice with homozygous knockout of IL-15 (here referred to as IL15KO/NeuT mice) were compared to IL-15 wild-type HER2/neu transgenic mice (NeuT) ...
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Altered cutaneous immune parameters in transgenic mice overexpressing viral IL 10 in the epidermis
... supernatants were collected 48 hours after culture. Preparation of serum. Blood was obtained from lethally anesthetized animals and allowed to clot at 4°C. Serum was collected after centrifugation at 1,000 g for 5 ...
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IL 13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
... inducible transgenic mice demonstrate increased survival in ...CC10–IL-13 transgenic mice have prominent anatomical alterations including inflammation and airway ...the IL-13 or ...
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Suppression of Her2/Neu mammary tumor development in mda- 7/IL-24 transgenic mice
... the IL-10 family of cytokines, and named IL-24 (mda-7/IL-24) ...with IL-20R1/IL-20R2 and IL-22R1/IL-20R2 cell surface receptors inducing autocrine and paracrine secretion ...
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Decreased severity of collagen antibody and lipopolysaccharide- induced arthritis in human IL-32β overexpressed transgenic mice
... (TNF-α), IL-1, IL-6, and ...properties, IL-32 is considered to develop the various inflammatory diseases, including inflammatory arthritis [5], inflammatory bowel disease [7], and certain ...
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Chronic Model of Inflammatory Bowel Disease in IL-10-/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging
... the incidence of IBD is still comparatively low, but it has recently been shown that the incidence of IBD is also rapidly growing in these counties [4]. In clinical practice, the diagnosis of IBD is mainly based on ...
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Expression of IL 5 alters bone metabolism and induces ossification of the spleen in transgenic mice
... the transgenic spleens (Figure ...to transgenic mice, as wild-type spleens failed to display any bone-related characteris- ...of transgenic mice were associated with cells that appear ...
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Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens
... structures on the surfaces of a wide range of pathogens, such as viruses, bacteria, and fungi via their carbohy- drate recognition domains (CRDs) and enhance phago- cytosis and killing by neutrophils and macrophages (3, ...
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Nanonized black soybean enhances immune response in senescence-accelerated mice
... senescence-accelerated-prone mice (SAMP8) and -resistant mice (SAMPR1, as ...SAMR1 mice were divided into the control groups and experi- mental groups supplemented with nanonized (Nano-soy) or ...
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The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
... analyzed mice with trans- genic expression of dominant negative forms of p38 MAPK in the ...genic mice developed cardiac hypertrophy after TAC despite having markedly reduced p38 MAPK activi- ...β ...
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Interleukin-6, Produced by Resident Cells of the Central Nervous System and Infiltrating Cells, Contributes to the Development of Seizures following Viral Infection
... IL-6-deficient mice (IL-6 deficient in the periphery) also re- sulted in fewer mice experiencing seizures (IL-6 ⫺/⫺ to WT) ...be IL-6 normal, while the remaining 20% would be ...
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Role of Inflammatory Cytokine-Induced Cycloxygenase 2 in the Ocular Immunopathologic Disease Herpetic Stromal Keratitis
... This study focuses on the early events in the pathogenesis of the blinding immunoinflammatory lesion SK caused by ocular infection with HSV. We show that corneal infection with HSV results in the upregulation of COX-2, ...
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High Pathogenicity of Wild-Type Measles Virus Infection in CD150 (SLAM) Transgenic Mice
... SLAM transgenic model for studies of novel antimeasles therapeutic approaches, we generated recombinant soluble SLAM and analyzed its antiviral activity in the transgenic ...
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