Imipenem/cilastatin
Imipenem cilastatin induced psychosis: a case report
... of imipenem-cilastatin was initiated because of his prior history of extended-spectrum beta- lactamase (ESBL) Klebsiella ...of imipenem-cilastatin was readjusted (increased) on his third day ...
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A multicenter, double-blind, randomized, comparison study of the efficacy and safety of tigecycline to imipenem/cilastatin to treat complicated intra-abdominal infections in hospitalized subjects in China
... the imipenem/cilastatin group were ...to imipenem/ cilastatin with respect to clinical response at TOC for all CE subjects, ie, the lower bound of the two-sided 95% CI ( - ...minus ...
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Efficacy and safety of tigecycline monotherapy vs imipenem/cilastatin in Chinese patients with complicated intra abdominal infections: a randomized controlled trial
... The primary efficacy endpoints were clinical response at the TOC visit for the m-mITT and ME populations. Microbiological response at the TOC visit by patient and isolate was performed as a secondary analysis. Because ...
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COST MINIMIZATION ANALYSIS OF MEROPENEM VERSUS IMIPENEM/CILASTATIN IN MODERATE TO SEVERE INFECTIONS AT A TERTIARY CARE GOVERNMENT TEACHING HOSPITAL – A PHARMACOECONOMIC AND EPIDEMIOLOGICAL STUDY
... of imipenem/cilastatin and meropenem in management of moderate to severe infections in different diagnosed ...with Imipenem/Cilastin and Meropenem were observed simultaneously in the period of ...
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Early use of imipenem/cilastatin and vancomycin followed by de escalation versus conventional antimicrobials without de escalation for patients with hospital acquired pneumonia in a medical ICU: a randomized clinical trial
... The strengths of our study include its prospective design, high initial prevalence of MDR organisms, and relatively high severity of infection. To our knowledge, this is the first randomized clinical trial comparing the ...
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A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra abdominal infections [Study ID Numbers: 3074A1 301 WW; ClinicalTrials gov Identifier: NCT00081744]
... for imipenem/cilastatin at the test-of- cure visit, demonstrating that tigecycline met the statisti- cal criteria for noninferiority compared with the carbap- enem ...
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Evaluation of the appropriateness of imipenem/cilastatin prescription and dosing in a tertiary care hospital
... and imipenem/cilastatin was continued based on her postculture ...developed, imipenem/cilastatin was discontinued and replaced by colistin (polymixin E) after consulting the infectious ...
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Comparison of Efficacy of Cefoperazone/Sulbactam and Imipenem/Cilastatin for Treatment of Acinetobacter Bacteremia
... Multiple antibiotic reisistance threatens successful treat- ment of Acinetobacter baumannii infections worldwide. In- creasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been ...
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Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates
... Imipenem/cilastatin encapsulated polylactide-co-gly- colide and polycaprolactone nanoparticles were success- fully prepared by double emulsion evaporation method. Antibacterial efficacy evaluation results ...
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ECONOMIC EVALUATION OF IMIPENEM CILASTATIN VERSUS DORIPENEM IN VENTILATORASSOCIATED PNEUMONIA IN EGYPT
... Deterministic baseline results from the model of DOR compared to IMI in the treatment of VAP suggest that DOR is more effective and less expensive than IMI (Table 2). Direct medical costs were obtained from the ...
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Molecular epidemiology of an outbreak of multidrug resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance
... with imipenem-cilastatin com- bined with gentamicin, decreased susceptibility to imipenem was ...the imipenem resistance of these strains, we hy- pothesize that, as previously reported for ...
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IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae
... but imipenem- susceptible Klebsiella pneumoniae ...weaker imipenem- hydrolyzing activity than that for other carbapenems, demonstrating that the antimi- crobial susceptibility profile of TA6363 originated ...
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Class 1 integron and Imipenem Resistance in Clinical Isolates of Pseudomonas aeruginosa: Prevalence and Antibiotic Susceptibility
... Background and Objectives: Pseudomonas aeruginosa is one of the most important causative agents of nosocomial infections especially in ICU and burn units. P. aeruginosa infections are normally difficult to eradicate due ...
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OCCURRENCE AND ANTIBIOGRAM OF IMIPENEM RESISTANT BACTERIA IN SACHET WATER SOLD IN CALABAR METROPOLIS, NIGERIA.
... widespread imipenem resistance among different genera of Gram-negative bacteria is an indication of rapid emergence of imipenem resistant ...of imipenem which are very useful in the overall treatment ...
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Phenotypic and Genotypic Detection of Metallo-Beta-Lactamases among Imipenem Resistant Gram Negative Isolates
... All imipenem resistant isolates were extracted by boiling method (12), Then PCR amplification was performed in a 25 µL reaction mixture containing 2 μL of DNA template, 12μL ready to use Mastermix ...
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Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study
... All isolates from various samples (blood cultures, urine, protected distal samples, sputum, drains and catheters…) were included. The strains were isolated on blood agar, chocolate agar, cemetol agar, King A and King B ...
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A gloves associated outbreak of imipenem resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
... Results: Thirty-nine IRABs were isolated from patients and the environmental surveillance culture in August, November, and December 2011. All isolates were resistant to imipenem. The IRAB strains belonged to seven ...
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Dissemination of imipenem resistant Acinetobacter baumannii with new plasmid borne bla OXA 72 in Taiwan
... without other resistance mechanisms against carbapenems. The transformation greatly increased the MICs of carbape- nems (64-128–fold), which was further supported by the elevated mRNA levels of OXA-72 in response to the ...
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Evaluation of the Synergistic Effect of EDTA Functionalized Chitosan Nanoparticles on Imipenem Delivery in Pseudomonas aeruginosa Carbapenem Resistant Strain AG1
... of imipenem were used to determine the minimum concentration leading to bacterial inhibition of ...of imipenem in- hibited bacterial growth even at high ...
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Outbreaks of Imipenem Resistant Acinetobacter Baumannii Producing OXA 23 β Lactamase in a Tertiary Care Hospital in Korea
... In our study, all imipenem-resistant A. baumannii isolates were positive for carbapenemase production and negative for metallo- β -lactamase. They all possessed the encoding gene for an intrinsic OXA-51-like ...
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