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immune evasion

The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus

The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus

... In summary, we have revealed that Sbi has an important role in determining the ability of S. aureus to avoid phagocytosis in human blood. We have shown that Sbi reduced the uptake of bacteria by human neutrophils in the ...

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Antibody trapping: a novel mechanism of parasite immune evasion by the trematode Echinostoma caproni

Antibody trapping: a novel mechanism of parasite immune evasion by the trematode Echinostoma caproni

... The decrease in the fluorescent signal for in vivo bound antibodies on worm surface during in vitro incubation is shown in S4 Fig. Loss of surface-bound antibodies during in vitro culture has been previously described in ...

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Implication of human herpesviruses in oncogenesis through immune evasion and supression

Implication of human herpesviruses in oncogenesis through immune evasion and supression

... in immune system evasion and ...the immune system, namely tumour-promoting inflammation, immune evasion, and ...their immune evasion and suppression mechanisms, and their ...

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Characterization of antigenic variants of hepatitis C virus in immune evasion

Characterization of antigenic variants of hepatitis C virus in immune evasion

... the immune evasion by antigenic variants described above is unlikely an occasional ...actual immune response in vivo as being used for HIV ...

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Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

... innate immune system is the first line of defense against invading ...innate immune system, resulting in the activation of downstream signaling pathways that then elicit an effective antimicrobial response ...

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Review of evidence for immune evasion and persistent infection in Lyme disease

Review of evidence for immune evasion and persistent infection in Lyme disease

... Research in microbiology, immunology, and genetics should further investigate how Borrelia spirochetes use mechanisms for immune evasion, biofilm-like niche-seeking behavior, and antibiotic tolerance to ...

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Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

... distinct immune escape, represented by an enrichment for mutations in immunotherapy-essential genes (such as HLA-A), expression of reg- ulatory immune signatures, including myeloid-derived, as well as ...

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Immune evasion in acute myeloid leukemia: current concepts and future directions

Immune evasion in acute myeloid leukemia: current concepts and future directions

... weak immune re- sponse upon encountering antigen-expressing AML cells in ...of immune evasion mechanisms which inhibit the generation or functional execution of anti-tumor immune ...of ...

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Conservation of a Unique Mechanism of Immune Evasion across the Lyssavirus Genus

Conservation of a Unique Mechanism of Immune Evasion across the Lyssavirus Genus

... form of STAT1 (3, 27, 45). The evolution of this highly specific mechanism may relate to the limited coding capacity of the RABV genome (36), such that P-protein, which has several vital roles in genome replication in ...

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Parasite epigenetics and immune evasion: lessons from budding yeast

Parasite epigenetics and immune evasion: lessons from budding yeast

... The immune evasion is directly linked to the silencing of the members of extended families of genes that encode for major parasite ...the immune system and cause prolonged ...

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Immune Evasion Strategies of Pathogens in Macrophages: the Potential for Limiting Pathogen Transmission

Immune Evasion Strategies of Pathogens in Macrophages: the Potential for Limiting Pathogen Transmission

... pumps protons into the vacuole using energy from ATP (IP et al., 2010). Yersinia pseudotuber- culosis can block the phagosome maturation by inhibiting V-ATPase activation (Tsukano et al., 1999). V-ATPase does not promote ...

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Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

... in immune and endothelial cells modulate cellular activities and contribute to the progression of several diseases, including ...of immune cells and discuss how metabolic communication between cancer and ...

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Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

... ABSTRACT Despite years of research and clinical advances, chronic pulmonary infections with mucoid Pseudomonas aeruginosa remain the primary concern for cystic fibrosis patients. Much of the research on these strains has ...

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The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome

The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome

... of immune evasion and resistance to ...of evasion: first, the elimination of neoantigen-containing tumour cells within a subset of the tumour population, and second, the acquisition of one or more ...

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Mechanism of immune evasion in breast cancer

Mechanism of immune evasion in breast cancer

... immune evasion has been recognized as a promising hallmark of BC in recent years. Gene mutations occasionally occur in somatic cells either spontaneously or owing to the combined action of various ...

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STAT3 enhancing germline mutations contribute to tumor extrinsic immune evasion

STAT3 enhancing germline mutations contribute to tumor extrinsic immune evasion

... Immune evasion is considered the hallmark of cancers ...the immune system to recognize and eliminate malignant cells have produced clinical ...(2). Immune evasion by tumor tissues has ...

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Surface Polysaccharides Promote Innate Immune Evasion By The Pediatric Pathogen Kingella Kingae

Surface Polysaccharides Promote Innate Immune Evasion By The Pediatric Pathogen Kingella Kingae

... Vanessa Lynne Muñoz was born June 28, 1991 in Elizabeth, NJ. She attended Brown University in Providence, RI and graduated with a B.A. in Business, Entrepreneurship, and Organization in 2013. She joined the University of ...

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Overcoming tumor immune evasion with an unique arbovirus

Overcoming tumor immune evasion with an unique arbovirus

... Combining dendritic cell vaccination with the adjuvant ef- fect of a strain of dengue virus may be a way to overcome known tumor immune evasion mechanisms. Dengue is unique among viruses as primary ...

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Antigenic Diversity and Immune Evasion by Malaria Parasites

Antigenic Diversity and Immune Evasion by Malaria Parasites

... site, but they are often clustered in sequences coding for B- or T-cell epitopes of malarial antigens. At the csp locus of P. falciparum, for example, nearly all nonsynonymous nucleotide replacements (i.e., those leading ...

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Phase-Dependent Immune Evasion of Herpesviruses

Phase-Dependent Immune Evasion of Herpesviruses

... the immune response, since the average number of epitopes is of the order of one per protein per HLA allele ...the immune system’s detection of a given ...an immune response is possible. However, the ...

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