Immune tolerance and transplantation
Original Article Adenovirus-mediated IL-10 transfection induces immune tolerance in corneal transplantation
... of immune tolerance, mainly through promoting Th2 cell differentiation, inhibiting proliferation of Th1 cells, and reduc- ing Th1 cells to secrete IL-2 and IFN-γ [22, ...tory immune response ...the ...
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Original Article IL-35 induces immune tolerance in renal transplantation rats by modulating CD4+CD25+ regulatory T-cells
... inducing immune tolerance in renal transplantation rats by modulating CD4+CD25+ regulatory ...renal transplantation rats, as well as expression of IL-6, IL-17, and ...induce immune ...
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Working toward immune tolerance in lung transplantation
... host immune regulation, even without generating durable spe- cific immune tolerance, is a worthwhile goal for ...prope tolerance was advanced origi- nally to explain success achieved in kid- ...
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Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation
... alloantigen-specific tolerance is attract- ive and theoretically possible and would help us reach the “ Holy Grail ” of transplantation, there is clearly still a long way to ...of immune tol- erance, ...
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Aging and the immune response to organ transplantation
... central immune tolerance, a potential problematic issue in older patients prone to ...transplant tolerance of skin and cardiac ...to transplantation tolerance after bone marrow ...
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Hematopoietic cell transplantation provides an immune-tolerant platform for myoblast transplantation in dystrophic dogs.
... an immune tolerant recipient, we induced immune tolerance in two DMD affected (xmd) dogs through hematopoietic cell transplantation ...
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Bcl-2-functionalized ultrasmall superparamagnetic iron oxide nanoparticles coated with amphiphilic polymer enhance the labeling efficiency of islets for detection by magnetic resonance imaging
... and immune tolerance research, the progress of islet allotransplantation and xenotransplantation and the noninvasive visualization of transplanted pancreatic beta cells or islets have become a major ...
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The Need for Tolerance in Pediatric Organ Transplantation
... ance. Immune tolerance refers to an acquired modifica- tion of the host immune system, achieved without chronic drug therapy, with which the specific response to the graft is suppressed but the ...
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Microchimerism maintains deletion of the donor cell–specific CD8+ T cell repertoire
... antigen-specific immune cells) has long been discussed (19, 20) as an explanation for unresponsive- ness to antigens expressed in fetal (21, 22) and neonatal life ...
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Exploiting Autoimmunity Unleashed by an Off-Label Low-Dose Immune Checkpoint Blockade to Treat Advanced Cancer
... peripheral tolerance arises from co-inhibitory signals rather than signals from the antigen receptor alone ('signal 1') was developed by Sinclair based on his unconventional view that the antigen receptor (TCR, ...
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Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation
... Flow cytometry. Three multicolor panels were used to assess cell-surface and intracellular protein markers in this study. The T cell panel included CD3-PerCP clone SP34-2, CCR7-PE clone 3D12, CD45-BUV395 clone D058-1283 ...
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Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
... organ transplantation is how to establish indefinite graft survival that is free from long-term treatment with immunosuppressive drugs and chronic rejection ...induce tolerance to transplanted hearts in ...
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Transplantation and diabetes (Transdiab): a pilot randomised controlled trial of metformin in impaired glucose tolerance after kidney transplantation
... renal transplantation which can be attributed to a few factors, mainly the use of im- munosuppressive medications (such as corticosteroids), Table 3 Difference between Lipid profile and weight change between the 2 ...
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Adeno-Associated Viral Vector-Driven Expression of Coagulation Proteins for Treatment of Hemophilias and Cancer
... responsible for this tolerization. Staining for CD4+CD25+FoxP3+ T cells and cytokine profiles of treated dogs suggest that induced Tregs are at least partially responsible for inducing and maintaining tolerance. ...
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Durable and sustained immune tolerance to ERT in Pompe disease with entrenched immune responses
... achieve immune tolerance or mitigate the immune response, including increas- ing the dose of therapeutic protein and implementing various drug regimens ...successful immune tolerance ...
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Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case
... of immune-pathological epitopes, ...sufficient immune modulatory informa- tion, for which exists a rationale that substantiates mouse to human translation, enabling them to act autonomous from primary ...
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The Thymus: A Forgotten, But Very Important Organ
... initiate immune reactions after transfer to an appropriate cell growth ...documented immune response defects in mice following ...of immune responses” ...
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Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non interventional observational trial
... The TruCulture® is a novel functional immune assay that will provide complex information about the im- mune function [24]. TruCulture® was developed at the Institut Pasteur, France, with the purpose to be incorpo- ...
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Mixed chimerism and tolerance without whole body irradiation in a large animal model
... Depletion of mature recipient and donor T cells is achieved in mice by the use of high doses of unconju- gated mAb’s. These antibodies remain active in the recipient plasma for 2 weeks after administration (48) and are ...
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Farber disease: clinical presentation, pathogenesis and a new approach to treatment
... cell transplantation can restore a healthy immune system and thus may provide a curative option in Farber Disease patients without neurological ...cell transplantation does not appear to be able to ...
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