Immunoglobulin heavy chain
Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region
... 15 immunoglobulin heavy chain constant (CH) and variable region (VH) polymorphisms were selected to span the entire length of the heavy chain ...
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Characterization of the immunoglobulin heavy chain complementarity determining region (CDR) III sequences from human B cell precursor acute lymphoblastic leukemia cells
... the immunoglobulin heavy chain complementarity determining region (CDR)-III of B-lineage cells at various stages has provided important insights concerning B cell maturation and ...the ...
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Monoclonal immunoglobulin heavy chain gene rearrangement in Fuchs’ uveitis
... of vitreous opacity in most (84–97%) examined patients with FU [3, 7], with dense vitreous opacity seen in 15% of those in the report [7]. In another, it was noted that a vitrectomy for removal of dense vitreous opacity ...
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Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
... and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become standard whereas fluorescent fragment analysis (GeneScan) has been used for ...
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The immunoglobulin heavy chain VH6-1 promoter regulates Ig transcription in non-B cells
... Background: Non-B cell immunoglobulins (Igs) are widely expressed in epithelial cancer cells. The past 20 years of research have demonstrated that non-B cell Igs are associated with cancer cell proliferation, the ...
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Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ
... mu chain protein and mRNA produced by pre-B cell hybrids from normal and X-linked agammaglobulinemic bone ...line heavy chain locus from this LS exon results in transcriptional activation of the JH ...
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Relation of mesangial IgA glomerulonephritis to polymorphism of immunoglobulin heavy chain switch region
... endonuclease Sst I and transferred to nylon membranes using the Southern blot procedure and hybridized with a probe homologous to the switch region of the Ig C mu gene (S mu) which detects RFLPs in both S mu and the ...
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Original Article Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia
... clonal immunoglobulin (Ig) light chain ...light chain restriction may be ...Ig heavy chain (HC) expression in lymphoid tissues in distinguishing lymphoid hyperplasias from BCLs, and ...
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Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes
... cDNA libraries for IgM heavy chain variable regions were prepared from unmanipulated peripheral blood lymphocytes of two healthy people. Partial sequencing of 103 clones revealed VH gene family use and ...
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Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
... Following successful IgH assembly and pre-BCR expression, V(D)J recombination is targeted to the light chain (IgL) genes (34–38). Those cells that produce in- frame IgL chains test their newly synthesized Igs for ...
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Regeneration of the immunoglobulin heavy chain repertoire after transient B cell depletion with an anti CD20 antibody
... The B-cell repertoire is shaped by a complex set of gene rear- rangements, somatic hypermutation and receptor-driven selection. These processes are highly regulated during devel- opment, ontogeny and the response to ...
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Identification of immunoglobulin heavy chain isotypes of specific antibodies of horse 46 group B meningococcal antiserum
... Although antibodies directed against other vaccine components may also be present in horse 46 serum, anticapsular polysaccharide and antiLPS could be specifically quantified and isolated[r] ...
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Anomalous rearrangements of the immunoglobulin heavy chain genes in human leukemias support the loop out mechanism of class switch
... of immunoglobulin genes are characteristic of lymphoproliferative diseases of B cells and provide direct evidence of their clonal ...Ig heavy chain gene ...Ig heavy chain gene between C ...
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B-cell malignancies: capture-sequencing strategies for identification of gene rearrangements and translocations into immunoglobulin gene loci
... the immunoglobulin heavy chain (IGH) locus and clonal rearrangements of the variable (V), diversity (D), joining (J), and constant (C) (V(D)J) segments of the immunoglobulin (Ig) genes are ...
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Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients
... Survival of patients with B cell chronic lymphocytic leukemia (B-CLL) can be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV). Patients without mutations ...
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Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation
... and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal ...
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Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United States tertiary care medical center
... of immunoglobulin heavy chain (IGH) and API2-MALT1(Vysis LSI BIRC3/MALT1 dual color dual fusion) translocations were examined by a bicolor FISH detection system, using a dual color break apart probe ...
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Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine
... 3-beta-HSD: 3-beta-hydroxysteroid dehydrogenase; Bip: Immunoglobulin heavy chain binding protein; CHOP: C/EBP homologous protein; CPU86017- RS: (+)-7R, 13aS-p-chlorobenzyltetrahydroberbe[r] ...
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Gluten sensitive enteropathy Immunoglobulin G heavy chain (Gm) allotypes and the immune response to wheat gliadin
... Anti-gliadin antibody was measured by radioimmunoassay in 30 Caucasians with gluten- sensitive enteropathy (GSE). 22 GSE patients maintained on a gluten-free diet for 1.5 to 20 yr (mean duration 76 mo) had elevated serum ...
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Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL
... IGH: Immunoglobulin heavy chain; LIGV-Miseq: LymphoTrack® IGHV-based deep sequencing assay (Miseq platform); MCF: Multi-color flow cytometry; MRD: Minimal (measurable) residual disease; [r] ...
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