influenza pandemic of 1918–19
A geographic analysis of population density thresholds in the influenza pandemic of 1918–19
... the influenza pandemic of ...for pandemic preparedness issued by public health agencies with a view to minimizing the impact of such events in the ...
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Age prioritized use of antivirals during an influenza pandemic
... the 1918–19 influenza pandemic in Copenhagen while treatment of elderly is more effective if age-specific case fatality rates are similar to those esti- mated for the 1969–70 influenza ...
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Differential Activation of NK Cells by Influenza A Pseudotype H5N1 and 1918 and 2009 Pandemic H1N1 Viruses
... 2009 pandemic H1N1 than that of H5N1 and 1918 ...of influenza viruses (12, 19, ...to influenza virus infection, and a dosage-dependent manner was found for NK cell activation by ...of ...
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Prior immunity helps to explain wave-like behaviour of pandemic influenza in 1918-9
... the pandemic sig- nature of a relatively greater mortality in young adults [6,50], aggregate influenza mortality in 2009 [6,10] seems lower than that from seasonal influenza, which typically affects ...
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Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus
... the 1918/rec virus, which is known to induce lethal infection upon experimental inoculation in ferrets and macaques (14, 38), was not highly virulent in pigs, indicating a potential resistance of swine to highly ...
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The evolution of pandemic influenza: evidence from India, 1918–19
... of 1918, and the clear pattern by which they demonstrate that the disease originated in Bombay and spread out across India from there (see Figure 2 and the Additional file 1: Video clip in the “Results” section ...
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Prior immunity helps to explain wave like behaviour of pandemic influenza in 1918 9
... seasonal influenza, as well as similar epitopes of H5N1 avian influenza ...live-attenuated influenza vaccine appear to protect against laboratory-confirmed influenza ...
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Spatial temporal excess mortality patterns of the 1918–1919 influenza pandemic in Spain
... measurable pandemic mortality impact in respiratory or all-cause data during May-July 1918 in both the Canary and Balearic Islands (Table ...the pandemic virus was not intro- duced into these Spanish ...
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Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses
... with pandemic viruses, gene expression continued to increase following infection, resulting in a 2-fold difference in expression levels from those of the seasonal viruses at later time ...the 1918 strain ...
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Different Evolutionary Trajectories of European Avian-Like and Classical Swine H1N1 Influenza A Viruses
... human influenza pandemic viruses all contained two or more novel genes that were very similar to those found in IAVs of wild birds, derived either by reassortment with circulating human strains in formation ...
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The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways
... the 1918:Tx/ 91(NS) virus relative to mock-infected ...the 1918 virus compared with that observed in mock-infected cells, indicating that the 1918 NS1 protein sup- pressed even low-level, ...
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Genetic Requirement for Hemagglutinin Glycosylation and Its Implications for Influenza A H1N1 Virus Evolution
... an influenza pandemic, which can threaten the lives of millions ...first pandemic of the 21st century was caused by an H1N1 subtype of IAV in 2009 (2009 H1N1) (3, ...the 1918 H1N1 “Spanish ...
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Time variations in the transmissibility of pandemic influenza in Prussia, Germany, from 1918–19
... Equation (2) is a slightly different expression of a method proposed for SARS [15]. The advantages of this model include: (i) we only need to know the time of onset of cases (i.e. the model does not require the total ...
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Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
... after 1918 is better understood: all three pandemic viruses since 1918 contain gene segments de- rived from the 1918 “founder” ...founding 1918 pandemic virus leading to ...
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"Will they just pack up and leave?" – attitudes and intended behaviour of hospital health care workers during an influenza pandemic
... perceived pandemic influenza to be very serious ...a pandemic, but nonetheless most were willing to work during a pandemic if a patient or colleague had ...against pandemic ...
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Oseltamivir Is Effective against 1918 Influenza Virus Infection of Macaques but Vulnerable to Escape
... The 1918 influenza virus, subtype H1N1, was the causative agent of the most devastating pandemic in the history of infectious ...reconstructed 1918 influenza virus in a highly susceptible and rele- ...
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Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin
... Intriguingly, we also observed marked differences in the cyto- pathicity of these chimeric avian viruses in differentiated primary NHBE cells, demonstrating that expression of different HAs can directly affect cell death ...
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The Receptor-Binding Domain of Influenza Virus Hemagglutinin Produced in Escherichia coli Folds into Its Native, Immunogenic Structure
... of influenza viruses, a recom- bination event occurred in which the gene for a primordial lectin molecule was incorporated into a membrane fusion do- main to provide sugar recognition abilities without compromis- ...
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Pandemic Influenza Preparedness Among Child Care Center Directors in 2008 and 2016
... for pandemic influenza: general infection control, communication, seasonal influenza control, use of health consultants, quality of child care, and perceived ...
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General hospital staff worries, perceived sufficiency of information and associated psychological distress during the A/H1N1 influenza pandemic
... The main methodological limitation of the present study lies in the response rate. An accurate estimation of the response rate was difficult, because the number of staff who could have been contacted during the 4- week ...
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