inhibitor kappa B-α
Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells
... κ B inhibitor named Da0324, an asymmetric MAC, which displayed tar- get selectivity for gastric cancer ...κ B- α protein (Figure ...TNF- α -induced NF- κ B activation by ...
17
Panduratin A, a possible inhibitor in metastasized A549 cells through inhibition of NF Kappa B Translocation and chemoinvasion
... In this study, we tested panduratin A for its in vitro inhibitory effects against NF-κB translocation activated by TNF-α and illustrated by HCS assay. Panduratin A exhibited significant inhibitory effects on the ...
16
IAP proteins as targets for drug development in oncology
... κ B subunit (the p50 sub- unit of NF- κ B1 or the p52 subunit of NF- κ ...the inhibitor of κ B (I κ B) ...NF-kappa-B inhibitor alpha (I κ B- α ) and ...
20
A new piece of an old puzzle: lack of association between C-Rel (rs13031237-rs842647) single nucleotide polymorphisms and non-segmental vitiligo
... IkB α : Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IKKb: Inhibitor of nuclear factor kappa-B kinase; IL: Interleukin; IRB: ...
5
Restraint Induces Sickness Responses Independent of Injection with Epstein Barr Virus (EBV) Encoded dUTPase
... (IL-6R α , IL-1R1), prostaglandin-endoperoxide synthase 2 (PTGS2) had a fold change of ...NF-kappa-B inhibitor-like protein 1 (NFKBIL1) had a fold change of ...
16
Download Download PDF
... ceed through multiple mechanisms, including autocrine or paracrine extracellular cytokine signaling, upstream oncogenic signaling mutations in NF- κ B and/or I- κ B, and in response to DNA damage. Cell ...
6
LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha.
... k B activation, our results suggest that LMP-1 causes continuous modifications of I k B a by at least two mechanisms: phosphorylation and ...k B a modifications induced by punctual stimuli such as ...
7
Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection
... Eight human IAPs such as NAIP (BIRC1), c-IAP1 (BIRC2), c-IAP2 (BIRC3), X-linked IAP (XIAP, BIRC4), Survivin (BIRC5), Apollon (BRUCE, BIRC6), Livin/ ML-IAP (BIRC7) and IAP-like protein 2 (BIRC8) have been identified ...
12
Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
... IKK α can be attributed to the absence of a water-bridging H-bond interaction with Asp102 but also to the removal of the conformationally restraining e ff ect of the 5-cyano group on the adjacent 4-phenyl ring ...
24
<p>The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7</p>
... UA was purchased from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China). Human breast cancer MCF-7 cells were obtained from Shanghai Cell Bank of Chinese Academy of Science ...
8
Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... SPSS19.0 statistical software was used for data analysis. Measurement data with normal distribution were expressed as the mean ± standard deviation (SD) and were analysed using analysis of variance. An LSD-t test was ...
5
School Desegregation, Law and Order, and Litigating Social Justice in Alabama, 1954 1973
... zoonotic B virus infection in humans, ...to B virus because pDCs are the primary source of abundant amounts of Type I interferons, the primary antiviral molecules in mammalian ...following B virus ...
141
Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B (NF-kB) p65 and Calcineurin Expression play a role in the regulation of muscle regeneration process through aerobic exercise in HIV patients
... Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B (NF-kB) p65 and calcineurin expression play a role in the regulation of muscle regeneration process through aerobic exerc[r] ...
6
Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B
... lium [9,11-13]. However, whether NTHi infections have effect on the expression of COX-2 and subsequent PGE2 in lung epithelial cells still remains uncertain. Lipid products of arachidonic acid including prostagland- ins ...
9
Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters.
... expression is critical for the regulation of early and late genes. Furthermore, the expression of this first set of genes is heavily dependent on host cell transcription factors. There are now several reported regions in ...
10
A NONKILLER RESISTANT KAPPA AND ITS BEARING ON THE INTERPRETATION OF KAPPA IN PARAMECIUM AURELIA
... Because B kappa were invariably present in resistant killer animals and mutants lacking B kappa were not resistant to killing activity, SONNEBORN (1959) suggested that complete r[r] ...
11
Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment Strategies
... Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by a reciprocal and balanced translocation involving the retinoic acid receptor α (RARa) on chromosome 17 and ...
20
OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D
... factor kappa-B ligand (RANKL), receptor activator of nuclear factor kappa-B (RANK) and plasma osteoprotegerin (OPG) levels, in T1D youngsters and to investigate factors that could influence ...
6
In vivo suppression of NF kappa B and preservation of I kappa B alpha by interleukin 10 and interleukin 13
... factor kappa B (NF-kappa B). Activation of NF-kappa B involves the degradation of its cytoplasmic inhibitor I kappa B alpha, allowing the nuclear ...
7
Microenvironmental stromal cells abrogate NF-kappa B inhibitor-induced apoptosis in chronic lymphocytic leukemia
... Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation (Ficoll-Histopaque, PAA Laboratories GmbH). In PBMC samples containing fewer than 90% CD5/CD19 positive cells as measured by ...
12