inhibitor of nuclear factor-kappa B
The expression of inhibitor of nuclear factor kappa-B kinase epsilon (IKKe) in human aortic aneurysm
... that inhibitor of nuclear factor kappa-B kinase epsilon (IKKe) is related to vas- cular inflammation, which accounts for its important role in the atherosclerosis, and it also has a ...
7
Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells
... proven to be nonpoisonous. Therefore, Da0324 may have a selection role to tumor cells. The effects of two symmetric MACs (EF24 and B19) on these cells were also measured. The IC 50 values of EF24 on the SGC-7901, ...
17
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
... k B/Rel family are critical for inducible expression of multiple genes involved in in- flammatory ...scription factor NF- k B is a target of sulfasalazine-mediated ...k B activation. NF- k ...
13
A new piece of an old puzzle: lack of association between C-Rel (rs13031237-rs842647) single nucleotide polymorphisms and non-segmental vitiligo
... : Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IKKb: Inhibitor of nuclear factor kappa-B kinase; IL: ...
5
Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain
... Based on the results of this preliminary observational study, the use of Pycnogenol combined with oral contraceptives in a continuous regimen appears to be more effective than oral contraceptives alone for the treatment ...
5
Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... Nuclear factor-kappa B (NF- k B)/Rel transcription factors play an important role in the inducible regulation of a vari- ety of genes involved in the inflammatory and proliferative ...
9
Targeting nuclear factor kappa B to overcome resistance to chemotherapy
... NF-κB inhibitor, Bay 11-7085, completely abrogated the apop- totic effects of cisplatin, indicating a pro-apoptotic role for NF-κB in this cell line (Chung et ...
10
Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis.
... and nuclear fractions were immunoblotted for p65-NF-jB, nucleoporing-p62 (a nuclear marker), and b-actin (a cytoplasmic ...an inhibitor of NF-jB activation, was ...NOX inhibitor, ...
21
Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B
... B converge on the IKK kinase complex, which acts as a master reg- ulator of NF- B ... B is initiated by binding of TNF-␣ to its receptors, TNFR1 and TNFR2, which results in activation of IKK ␣ ...
13
Inhibition of osteoclastogenesis by RNA interference targeting RANK
... NF-kappa B: Nuclear factor `kappa-light-chain-enhancer` of activated B-cells; RANK: Receptor activator of NF- kappa B; RANKL: Receptor activator of NF- kappa ...
9
Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... an inhibitor of nuclear factor kappa light chain en- hancer of activated B cells (NF-κB), on the radiosensitivity of human pancreatic cancer cell line Sw1990, and to explore the ...
5
IAP proteins as targets for drug development in oncology
... IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IAPs, inhibitors of apoptosis; IL, interleukin; IKK, IκB kinase complex; LUBAC, linear ...
20
PubMedCentral-PMC5655742.pdf
... Our focus upon TNF stems from its roles as a “ sentinel cytokine, ” largely post-transcriptionally regulated, and as an acute-phase initiator of oxidant species and NF j B-driven (and other) responses that have ...
12
Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... Previous efforts to identify age-associated changes in cel- lular homeostasis have largely relied on cells senesced in vitro or on the investigation of fast proliferating cells. In the present investigation, we focus on ...
8
The role of A20 in the pathogenesis of lymphocytic malignancy
... Increasing data support the notion that A20 is a tumor suppressor. When re-expressed in a lymphoma-derived cell line with no functional A20 alleles, wildtype but not mutant A20 resulted in cell growth suppression and ...
7
Ionizing radiation induces expression and binding activity of the nuclear factor kappa B
... transcription factor NF-kappa ...of nuclear factor (NF)kappa ...NF-kappa B binding activity was maximal at 2-4 h and then declined to pretreatment ...NF-kappa ...
6
Effects of cannabinoids on IL 1alpha induced bovine chrondrocyte metabolism and cartilage resorption
... cysteine protease known as Interleukin 1-Converting Enzyme (ICE also known as caspase-1) is highly specific for cleaving prolL-1 p but does not cleave the IL-la precursor. Other enzymes have been found that do cleave the ...
238
Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model
... were incubated overnight with primary antibodies, includ- ing the rabbit monoclonal antibodies anti-NQO1 (1:1000; Abcam, ab80588), anti-HO1 (1:1000; Abcam, ab68477), anti-LC3A/B (1:1000; Cell Signaling Technology, ...
11
Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane damage [8]; (iii) local hyperkalaemia could ...
18
The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... k B site (Figure 4.7) suggests an involvement of the NF- k B site in the retinoic acid mediated ...k B site and thus occlusion of NF- k B binding, thereby preventing NF- k B ...k ...
171