Innate immune
Trauma: the role of the innate immune system
... The scoring systems ought to be used to define the appro- priate therapy. Damage control surgery and damage con- trol orthopedics are currently used strategies to limit the incidence of organ failure after trauma ...
11
Innate immune signalling of the zebrafish embryo
... in innate immunity at later stages of embryo- ...the innate immune response by nucleic acids is known to be me- diated via TLR3, TLR7 and TLR9 ...
137
Innate immune defences in the human endometrium
... The human endometrium is an important site of innate immune defence, giving protection against uterine infection. Such protection is critical to successful implantation and pregnancy. Infection is a major ...
8
The Receptor That Tames the Innate Immune Response
... activate innate immune responses driven by tumor necrosis factor (TNF)- α and other proinflammatory cytokines that typically increase damage surrounding a ...
11
Alphacoronavirus Protein 7 Modulates Host Innate Immune Response
... vival, many viruses have developed different strategies that counteract the host antiviral responses triggered by dsRNA (27). Many of the virus-encoded proteins with this activity identified to date interfere with ...
14
The Fungal Quorum Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity
... In the first study identifying FOH as a QS molecule of the patho- genic yeast C. albicans, Hornby et al. defined two competing hy- potheses with FOH either being a possible therapeutic compound due to its ability to ...
14
Innate Immune Response to Coxiella Burnetii
... of innate immune pathways in macrophages by either failing to activate these pathways or blocking activation through the use of its specialized Type IV secretion system ...robust innate immune ...
151
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway
... consequently, spermidine and spermine. Supporting this idea, we found that spermi- dine and spermine concentrations were increased when CTH/CBS or AHCY inhibitors were used. Concomitantly, the intracellular pool of dcSAM ...
18
Inactivated Influenza Vaccine That Provides Rapid, Innate Immune System Mediated Protection and Subsequent Long Term Adaptive Immunity
... The innate and adaptive immune systems differ in mechanisms, specificities, and times at which they take ...The innate immune system responds within hours of exposure to infectious agents, ...
11
Antiviral Innate Immune Response Interferes with the Formation of Replication Associated Membrane Structures Induced by a Positive Strand RNA Virus
... from innate immune detection. We hypothesized that the innate immune response has tools to counteract the formation of these virus-induced replication organelles in order to inhibit virus ...
11
A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses
... by immune cells, mainly neu- trophils, which play a pivotal role in maintaining periodontal health by employing diverse and potent bactericidal mechanisms (2, ...and innate immunity (2, ...human ...
15
Expanding the organismal proteostasis network: Linking systemic stress signalling with the innate immune response
... The Innate Immune Response in Mammals: Toll-like Receptor (TLR) Signaling Pathways In contrast to ...regulate innate immune responses by inducing speci fi c signaling pathways to clear ...
16
Innate immune functions in kidney transplantation
... In humans, individuals defi cient for properdin are prone to lethal pyonenic (particular neisserial) infections [53;54]. Mice defi cient for properdin provided evidence that properdin is essential in driving LPS-mediated ...
160
Recognition of herpesviruses by the innate immune system
... the innate immune system and stimulate antiviral activities has grown tremendously over the past ...the innate immune response and establish persistent ...in immune defense and ...the ...
42
CD8 T Cells in Innate Immune Responses: Using STAT4 Dependent but Antigen Independent Pathways to Gamma Interferon during Viral Infection
... of innate cytokines in promoting naive T cell responses (19, 21, 45, 46) used to suggest a model for activation and expansion which requires three differ- ent signals delivered through (i) the TCR, (ii) ...
14
Toll like receptor–mediated NF κB activation: a phylogenetically conserved paradigm in innate immunity
... TLRs are evolutionarily conserved and their congeners have been found in insects, plants, and mammals. Drosophila Toll (dToll) was the first member of the TLR family to be identified, and was initially characterized as a ...
8
Acute kidney injury: what part do toll-like receptors play?
... The innate immune system plays an important role as a first response to tissue ...initiate innate immune responses and con- currently shape the subsequent adaptive immune ...
11
Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study
... When intracellular expression of Th1 (IFN-g), Th2 (IL-4), Th17 (IL-17A), and regulatory cytokines (IL-10 and TGF-ß) were examined in 6/8 ASD/SPAD children, we observed lower intracellular expression of TGF-b in CD4 + ...
12
Immune parameters, symptoms of upper respiratory tract infections, and training-load indicators in volleyball athletes
... in innate immune cells (specifi- cally monocytes and neutrophils), and a decrease in adaptive immune cells (total lymphocytes) and higher incidence of upper respiratory tract infections from the M1 ...
8
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
... and innate immunity have intertwined ...the innate immune response such as tumor necrosis factor alpha (TNFα) and nitric oxide synthase (iNOS) (producing nitric oxide [NO]), and promotes neutrophil ...
14