Insulin Receptor Substrate Proteins
Expression and function of the insulin receptor substrate proteins in cancer
... IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic ...IRS proteins differentially contribute to tumor cell function and the manner in which their ...
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... We monitored a cohort of CIRS12KO mice and WT littermate controls starting at birth. All CIRS12KO animals died by the age of 11 weeks, with the majority dying by 8 weeks (Figure 2F). Trans- thoracic echocardiography ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... Pim substrate(s) that could help define the pathway regulated by these enzymes and potentially serve as a biomarker of Pim ...identify proteins containing a consensus Pim phosphorylation ...the ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... Islet morphology and immunohistochemistry. For immunohistochemistry, pancreatic sections were fixed for 16 hours in 4% paraformaldehyde and then trans- ferred to PBS until embedding in paraffin as previ- ously described ...
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... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and IN/IGF-1/IRS1/ ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin secretion and by insulin resistance of the major target tissues ...particular, insulin resistance of the skeletal muscle appears to play a pivotal role in the pathogenesis of the disease ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... Multiple histone acetyltransferases (HATs) and histone deacetylases (HDACs) control the state of histone acetyla- tion and hence play a regulatory role in modulating the structure and function of chromatin [25]. About 20 ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone ...with insulin or IGF-I failed to induce tyrosine ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth ...
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L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... isolated. Proteins were extracted by boiling the tissues in ...The proteins (25 μg/lean) were electrophoresed using ...the proteins were transferred onto a PVDF membrane (Amersham Life Science ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... Protein lysate preparation and Western-blot analysis Protein lysates were prepared from the microdissected hippo- campal subfield CA1 at 4 u C as previously described [105]. Protein concentrations were determined by BCA ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... Here we have tested the immune response of D. melano- gaster flies mutant for the insulin receptor substrate Chico against pathogenic and non-pathogenic bacteria. We have chosen to use a professional ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... leptin receptor in POMC neurons generates mice that have some phenotypic features in common with RIPCreIrs2KO mice, including obesity ...4 receptor–null mice, which resemble RIPCreIRS2KO and NesCreIRSKO ...
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Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes
... for insulin receptor (IR) with FastStrat Universal SYBR Green Master (Roche) and primers (for- ward 5′-CGGCCAGAGGCTGAGAATAAT-3′, reverse 5′-CGCCATCTGAATCA ...
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Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer
... ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor ...and insulin-like growth factor (IGF) ...phosphorylate insulin receptor substrates ...
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MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
... the insulin receptor substrate 1 (IRS1) was a direct functional target of miR-1225-5p in glioblastoma, and the mRNA and protein levels of IRS1 in six human glioblastoma cell lines (A172, SW1783, U87, ...
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microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB
... microRNA-7-5p (miR-7-5p) is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor (EGFR) signaling pathway. ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... leptin receptor–positive areas, we performed in situ hybridization on brain sections that included the hypo- ...leptin receptor–positive areas in the arcuate nucleus of the hypothalamus (Figure ...assess ...
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