Insulin Secretion in Vitro
The in vitro inhibition of insulin secretion by diphenylhydantoin
... on insulin release in vitro using preparations of isolated islets of Langerhans and pancreatic pieces was ...the insulin secretory response of pancreatic pieces to methacholine, 1 µg/ml, tolbutamide, ...
8
Direct glucocorticoid inhibition of insulin secretion An in vitro study of dexamethasone effects in mouse islets
... plasma insulin levels in humans and animals ...the insulin resistance that steroids cause in liver, muscle, and adipose tissues, and is likely to be mediated by the concomitant slight elevation of plasma ...
11
Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets
... micrograms/g diet. Release normalized with RA, 8 micrograms/g diet. Vitamin A deficiency did not affect islet insulin content, cell size, number or structure. In vivo, vitamin A-deficient rats had impaired ...
8
PAC1 receptor–deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance
... In vitro, in the isolated perfused pancreas, the insulin secretory response to PACAP was reduced by 50% in PAC1 –/– mice, whereas the response to VIP was ...glucose-stimulated insulin ...
10
The antihyperglycemic effect of Bridelia ndellensis ethanol extract and its fractions is mediated by an insulinotropic action
... on Insulin secretion was evalu- ated using BRIN-BD11 pancreatic ...the insulin secre- tion from BRIN-BD11 cells in ...of insulin release was significantly different when compared to control ...
5
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells
... stimulate insulin se- cretion ...of insulin secretion is due to an increased level of the specific amino acids in vivo ...in vitro insulin secretion, in sup- port of such an ...
7
Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress
... glucose-induced insulin secretion in mice and induces diabetes ...in vitro after washout of glibenclamide and in vivo after termination of glibenclamide treatment, the adverse effects were fully ...
12
Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response
... In vitro and in vivo results showed that sustained release of HGF by KLD2R/Hep gel significantly enhanced β -cell survival and insulin secretion by inhibiting NF κ B/p38 pathways, inflam- matory ...
16
Lessons in human biology from a monogenic pancreatic β cell disease
... of insulin secretion resulting in ...in vitro studies of pancreatic tissue obtained from CHI patients dur- ing therapeutic pancreatectomy that have yielded exciting new insights into human β cell ...
6
Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro
... In the present study, the TCF7L2 and GLP-1 gene expressions were significantly decreased in STZ-treated islet cells. Treatment with NCD in control islets, and before or after STZ exposure significantly increased TCF7L2 ...
12
Calcitonin Secretion under Insulin Hypoglycemia
... increasing secretion of calcitonin and hypocalcemia under insulin hypoglycemia, induced with insulin injection (1 IU/100g), was ...of insulin hypoglycemia on calcitonin secretion were ...
8
Insulin secretion in response to protein ingestion
... In an effort to determine the effect of leucine on insulin release under physiologic circumstances, protein meals rich in leucine were fed to healthy subjects, and the levels of plasma i[r] ...
9
Diabetes in dogs and cats: an update
... ordinary human insulin at three positions. Glargine is a clear and colourless solution, not a suspension like other long-acting insulins. It contains 100U/ml insulin and should not be diluted before ...
6
Stimulation of insulin secretion by amino acids
... We conclude that 1 intravenous administration of mixtures of essential I-amino acids induces release of insulin; 2 the phenomenon of amino acidinduced release of insulin does not depend [r] ...
17
Increased glucose effectiveness in normoglycemic but insulin resistant relatives of patients with non insulin dependent diabetes mellitus A novel compensatory mechanism
... However, insulin sensitivity (Si) was reduced ...Despite insulin resistance neither fasting plasma insulin concentration ...phase insulin responsiveness (Phi1) ...of insulin resistance ...
10
Early postprandial Insulin secretion: Its relation to Insulin sensitivity
... prandial insulin secretion in controlling post prandial glycemia is well established ...prandial insulin secretion in onset of post prandial hyperglycemia or IGT in early stages of evolution ...
5
TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity
... prandial secretion of insulin, proinsulin, and C-peptide in the rs7903146 T allele carriers when compared with the absence of the ...both insulin secretion and postprandial insulin ...
7
Neural Regulation of Insulin Secretion in the Dog
... changes. Insulin responses to ...inhibit insulin secretion by activation of the sympathetic nerves and to stimulate insulin secretion by activation of the parasympathetic ...
6
Use of Rosiglitazone for Clomiphene Resistant Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial
... Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age group affecting 5-10% of premenopausal women exhibiting the full blown syndrome of hyperandrogenism, chronic anovulation ...
10
Mechanisms of glucagon secretion during insulin induced hypoglycemia in man Role of the beta cell and arterial hyperinsulinemia
... hyperinsulinemic-euglycemic clamp (FIRI 63 +/- 1.5 or 147 +/- 0.3 microU/ml, respectively) before hypoglycemia, the alpha cell responses to hypoglycemia were identical to those of the control study. When the endogenous ...
7