insulinlike growth factor 1
Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence.
... Levy Place, New York, New York 10029-6574,1 and Hormone Research Institute, School of Medicine, University of California, San Francisco, California 94J432 The human insulinlike growth fa[r] ...
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Insulinlike Growth Factor-1Ec (MGF) Expression in Eutopic and Ectopic Endometrium: Characterization of the MGF E-Peptide Actions In Vitro
... the insulinlike growth factor 1 (igf-1) gene generates three mRNA isoforms, namely IGF-1Ea, IGF-1Eb and IGF- 1Ec (or MGF [mechano growth ...the growth of the KLE cells. ...
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Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin C/insulinlike growth factor I
... somatomedin-C/insulinlike growth factor (Sm-C/IGF-I) binding to human fibroblasts in both adherent monolayers and in suspension ...between 1 and 10 ng/ml ...
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A unique receptor independent mechanism by which insulinlike growth factor I regulates the availability of insulinlike growth factor binding proteins in normal and transformed human fibroblasts
... assessed by Western ligand blotting; IGF-I decreased levels of 24 kD IGFBP in normal HF cultures. The IGF-I-induced change in IGFBP levels was not a type I IGF receptor-mediated effect on IGFBP synthesis because (a) high ...
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Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I
... erythropoietin (Ep), the best-characterized erythropoietic activity so far. The erythropoietic activity of FBS was found in the 120-160- and 40-70-kD range at neutral pH. In the presence of 1 M acetic acid, ...
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Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells
... that insulinlike growth factor I (IGF-I) inhibits growth hormone (GH) secretion and messenger RNA (mRNA) levels in pituitary ...for 1 h inhibited GH gene transcription to 60% of ...
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Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance
... Collectively, the effects of hIGFBP1 on 39 endothelial cell responses and acceleration of endothelial regeneration in mice indicate that 40 manipulating IGFBP1 could be exploited as a pu[r] ...
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Radioimmunoassay of growth hormone dependent insulinlike growth factor binding protein in human plasma
... a growth hormone-dependent insulinlike growth factor (IGF) binding protein (BP) from human ...Strong growth hormone-dependence of BP was also seen; there was a ...
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Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy
... Since the identification of the causative mutation, much has been learned about the molecular mechanism of SBMA through both in vivo and in vitro studies. The AR is a member of the nuclear hor- mone receptor superfamily ...
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Secretion of insulinlike growth factor I and insulinlike growth factor binding proteins by murine bone marrow stromal cells
... transcription/polymerase chain reaction. To determine whether the greater than 25-kD species identified by RIA possessed IGF-binding activity, a potential cause of artifactual IGF-I immunoreactivity, charcoal adsorption ...
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Mitogenic response of canine fundic epithelial cells in short term culture to transforming growth factor alpha and insulinlike growth factor I
... epidermal growth factor and transforming growth factor alpha (TGF alpha) (10 pM to 1 nM), insulin (10 nM to 1 microM) and insulinlike growth factor-I (IGF-I, ...
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Bioactive Compounds for the Treatment of Renal Disease
... include 1) identification of renal stem/ progenitor cells in embryonic and adult kidneys, 2) cell thera- pies with hematopoietic, mesenchymal or fetal stem cells, and 3) reconstruction of artificial kidneys or ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... of growth hormone could also contribute to the disappointing activity of this class of ...of growth hormone, a compensatory reaction to IGF-1R antibodies ...tumor growth in HCC cell line HepG2, and ...
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Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor
... such insulinlike growth factors as multiplication stimulating activity (MSA) are related polypeptides that have common biological ...as growth effects (stimulation of [ 3 H]thymidine incorporation ...
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The effects of infusion of insulinlike growth factor (IGF) I, IGF II, and insulin on glucose and protein metabolism in fasted lambs
... Results Plasma hormone concentrations The low and high dose rhIGF-I infusions increased the plasma IGF-I concentration above baseline by two- and fivefold, respectively, whereas infusion[r] ...
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Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... regulatory factor with multiple functions, TGF-b1 participates in several important pathophysiological processes, and is currently studied ...tissue growth factor (CTGF) and TGF-b1 levels in hepatic ...
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Expressions of Growth Factors in Autologous Derived Platelet-Rich Plasma and Platelet-Poor Plasma; Implication for Tissue Reparation and Wound Healing
... It is crucial to minimize platelet activation that occurs during PRP preparation, this is because activation results in untimely release of GFS, which could result in deletion of expressed GFs at the point of use. ...
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Affinity labeled plasma somatomedin C/insulinlike growth factor I binding proteins Evidence of growth hormone dependence and subunit structure
... Sepharose. When acromegalic or normal plasma was fractionated on a Sephadex G-200 column and affinity labeled, the same complexes that were adsorbed by concanavalin A were found in fractions that eluted near the ...
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Adult growth hormone deficiency treatment with a combination of growth hormone and insulin like growth factor 1 resulting in elevated sustainable insulin like growth factor 1 and insulin like growth factor binding protein 3 plasma levels: a case report
... However, the use of GH replacement therapy has not always resulted in consistent increases of IGF-1 in AGHD patients. The mechanism of this inconsistency has been studied by De Gennaro et al. [3]. In a series of ...
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Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population
... There are some reports on platelet counts in PRP and GF levels (Anitua et al., 2009; Eppley et al., 2004; Magalon et al., 2014; McCarrel & Fortier, 2009; Sanchez et al., 2007). Despite earlier reports in the ...
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