Interferon gamma receptor
Recurrent Mycobacterium avium Osteomyelitis Associated With a Novel Dominant Interferon Gamma Receptor Mutation
... the interferon- ␥ receptor (IFN- ␥ ...truncated receptor without an intracytoplasmic tail, resulting in diminished ...truncated receptor in a 7-year- old girl with recurrent M avium ...avium, ...
5
Mutation in the signal transducing chain of the interferon gamma receptor and susceptibility to mycobacterial infection
... g receptor is composed of at least two subunits, IFN g R1 and IFN g R2, both of which are transmembrane pro- ...g receptor complex and the role of its components in signal transduction have been well ...
7
Demonstration and partial characterization of the interferon gamma receptor on human mononuclear phagocytes
... 125I-IFN gamma into trichloroacetic acid-soluble counts at 37 degrees C but not at 4 degrees C, at an approximate rate of 5,000 molecules/cell per ...The receptor was partially characterized by ...
11
High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency
... organism, our results suggest that patients with com- plete IFN ␥ R deficiency cannot eliminate blood IFN ␥ , resulting from a lack of binding (IFN␥R1 deficiency) or a lack of internalization (IFN ␥ R2 deficiency) of the ...
5
Interferon-Gamma Gene Polymorphism in Patients with Tuberculosis
... 20-Kamijo R, Gerecitano J, Shapiro D, Green SJ, Aguet M, Le J, et al. Generation of nitric oxide and clearance of interferongamma after BCG infection are impaired in mice that lack the interferon-gamma ...
7
Discrepancy between the in vitro and in vivoeffects of murine mesenchymal stem cells on T cell proliferation and collagen induced arthritis
... IFN-g: interferon-gamma; IFN-gR KO: interferon- gamma receptor knockout; IL: interleukin; iNOS: inducible nitric oxide; MSC: mesenchymal stem cell; NO: nitric oxide; PBS: ...
11
Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... I interferon signaling in IBC not only sheds light on the molecular underpinnings of the disease but also provides novel mechanisms of targeted therapy and drug resistance to be considered in the con- text of ...
10
Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
... dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non- small cell lung cancer cells. Asian Pac J C[r] ...
14
Immune Response to Mouse Mammary Tumor Virus in Mice Lacking the Alpha/Beta Interferon or the Gamma Interferon Receptor
... Many cytokines are likely to be involved in the interactions between MMTV and the immune system. In particular, we were interested in the role played by alpha/beta interferon (IFN-a/b) and gamma ...
9
The talented interferon gamma
... patterns. Interferon-γ (IFN-γ) was first named Immune IFN, then later Type II ...its receptor is expressed ubiquitously on almost all cell ...its receptor triggers the Janus kinase (JAK)/Signal ...
8
IMMUNOREGULATION OF LIVER REGENERATION BY THE ARYL HYDROCARBON RECEPTOR: ROLE OF LYMPHOCYTES AND INTERFERON-GAMMA
... Fc receptor block (BD Biosciences, San Jose, CA) for 10 minutes before staining with the following fluorochrome-conjugated antibodies purchased from BD Biosciences: ...
60
Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer
... hormone receptor-positive (cases with positivity for estrogen and/or progesterone receptor by CLIA-cerified immunohistochemistry), stage I-III BC cohort (N = 362) was extracted from two Yale University BC ...
9
Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... coupled receptor; GSK‑3β: glycogen synthase kinase‑3β; HbA1c: glycosylated haemo‑ globin; HDL: high‑density lipoprotein; HMDS: hexamethyldisilazane; HREC: Health Research Ethics Committee; hs‑CRP: high sensitivity ...
15
Clinical significance of tumor-infiltrating lymphocytes in breast cancer
... Augmenting immunity through conventional breast cancer chemotherapy and monoclonal antibody therapy A major mechanism of action of trastuzumab therapy in HER2 + breast cancer may be immunologic. Monoclonal antibodies can ...
7
The human gamma interferon receptor accessory factor encoded by chromosome 21 transduces the signal for the induction of 2',5'-oligoadenylate-synthetase, resistance to virus cytopathic effect, and major histocompatibility complex class I antigens.
... 1702-1706 0022-538X/93/031702-05$02.00/0 Copyright © 1993, American Society for Microbiology The Human Gamma Interferon Receptor Accessory Factor Encoded by Chromosome 21 Transduces the [r] ...
5
Genome of Deerpox Virus
... including gamma interferon receptor (IFN- ␥ R; DPV010), interleukin-1 receptor (IL-1R; DPV015), IFN- ␣ / 〉 P (DPV147), IL-18BP (DPV021), major histocompatibility complex class I (MHC-I)-like ...
12
Case report: mechanisms of HIV elite control in two African women
... : Interferon-gamma; ART: Antiretroviral therapy; CAPRISA: Centre of the AIDS Programme of Research in South Africa; CCR5: C-C chemokine receptor type 5; CDKN1A-p21: Cyclin-dependent kinase inhibitor; ...
7
Phenotype and functional changes of Vγ9/Vδ2 T lymphocytes in Behçet's disease and the effect of infliximab on Vγ9/Vδ2 T cell expansion, activation and cytotoxicity
... Methods: We investigated 1 cell expansion, 2 expression of TNFRII receptor, 3 perforin and gamma interferon IFN content, 4 release of granzyme A GrA and 5 phenotype changes, in vitro and[r] ...
6
A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency
... Several experiments were carried out in order to confirm the abnormal functionality of the receptor (Fig. 3). The monocytes of the patient presented a clear deficit in TNF-␣ production when stimulated with E. ...
5
Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... ABSTRACT Blood-brain barrier (BBB) breakdown is a hallmark of many diseases of the central nervous system (CNS). Loss of BBB integrity in CNS diseases such as viral encephalitis results in the loss of nutrient/oxygen ...
21