Interferon Regulatory Factors
Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
... viral interferon (IFN) regulatory factor 3 ...lar interferon regulatory factors (IRFs) that play a critical role in type I IFN gene induction and IFN ...
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Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase
... viral interferon regulatory factors (vIRFs) specified by HHV-8 are believed to be major contributors to suppression of innate immune responses to virus infection and pro- ductive replication and to ...
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Differential Regulation of Human Papillomavirus Type 8 by Interferon Regulatory Factors 3 and 7
... The genus  human papillomavirus (HPV) type 8 is associated with nonmelanoma skin cancer in patients with epidermodysplasia verruciformis, and evidence for its protumorigenic potential in the general population ...
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Role of cellular caspases, nuclear factor kappa B and interferon regulatory factors in Bluetongue virus infection and cell fate
... Results: In this report, we investigated BTV-induced apoptosis in cell culture in depth and show that both extrinsic (caspase-8 activation) and intrinsic (caspase-9 activation) pathways play roles in BTV apoptosis. ...
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Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors
... transcription factors of the interferon regulatory factor (IRF) ...alpha/beta interferon (IFN) genes, HHV-8 has evolved a mechanism by which it directly subverts the functions of IRFs and ...
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Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.
... In this study, we demonstrate that the formation of the PRDII-specific complexes preceded the onset of detectable IFN-P transcription in Sendai virus-infected cells and, using NF-KB subu[r] ...
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Rotavirus NSP1 Inhibits Expression of Type I Interferon by Antagonizing the Function of Interferon Regulatory Factors IRF3, IRF5, and IRF7
... In an earlier study, we showed that infection with wt rota- virus leads to a rapid and nearly complete loss of the consti- tutively expressed transcription factor IRF3 (4). Here we showed that infection with wt rotavirus ...
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Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
... T he interferon (IFN) response is integral to a host’s antiviral defenses. IFNs are divided into three distinct types (types I to III), characterized by sequence, receptor usage, and biological ac- tivity (18). ...
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Rotavirus NSP1 Mediates Degradation of Interferon Regulatory Factors through Targeting of the Dimerization Domain
... of interferon (IFN) and IFN-stimulated gene products by inducing proteasome-mediated degradation of IFN-regulatory factors (IRFs), including IRF3, IRF5, and ...
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Viral Interferon Regulatory Factors Are Critical for Delay of the Host Immune Response against Rhesus Macaque Rhadinovirus Infection
... K aposi’s sarcoma (KS)-associated herpesvirus (KSHV) is a gamma-2 gammaherpesvirus that was identified in 1994 to be the cause of AIDS-related KS (11), one of the most common ma- lignancies within human immunodeficiency ...
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The Viral Interferon Regulatory Factors of Kaposi's Sarcoma-Associated Herpesvirus Differ in Their Inhibition of Interferon Activation Mediated by Toll-Like Receptor 3
... vIRF1, -2, and -3 inhibit TLR3-activated interferon promoter elements. KSHV downregulation of TLR3 and its downstream responses suggests that TLR3 may be a target of KSHV immune inhibition. As both vIRF1 and vIRF3 ...
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Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
... codelivered interferon regulatory factor (IRF) genes for DNA ...transcription factors that serve as mediators for the activation of early inflammatory responses to viral ...inflammatory ...
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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
... NIH 3T3 cells constitutively overexpressing vIRF-1 gained the ability to grow in soft agar and to form tumors in nude mice. These data indicate that vIRF-1, like IRF-2, behaves as an oncogene. However, the molecular ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factors (vIRFs), vIRF1 to vIRF4, which are homologous to cellular IRFs, which are clustered within one genomic locus ...host interferon response and control ...
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Regulation of interferon regulatory factor3.pdf
... I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription ...tion factors nuclear factor B and ATF-2/c-Jun have been ...
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Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
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Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties
... Interferon regulatory factors (IRFs) are a small family of transcription factors with multiple ...these factors is a conserved N-terminal DNA binding domain which mediates binding to ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... NSP1 interacts with IRF-3. We performed a two-hybrid interaction screen with bovine NSP1 as bait to identify candi- date cellular partners of NSP1 that would shed light on the function of this protein in ...
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Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor
... Interferons (IFNs) are a family of multifunctional cytokines with antiviral activities. The K9 open reading frame of Kaposi’s sarcoma-associated herpesvirus (KSHV) exhibits significant homology with cellular IFN ...
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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor
... viral interferon (IFN) regulatory factor (vIRF) which functions as a repressor for cellular IFN-mediated signal transduction and as an oncoprotein to induce cell growth ...
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