Interferon-Stimulated Gene Factor 3
Characterization of the Elements and Proteins Responsible for Interferon-Stimulated Gene Induction by Human Cytomegalovirus
... key factor in this ...virus-activated factor complex that contains the cellular pro- teins IRF-3 and IRF-7 and the transcriptional coactivator pro- teins p300 and CBP (16, 18, 22, 23, 32, ...(Fig. ...
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Δγ134.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response
... innate interferon (IFN)-mediated antiviral response, inducing effector proteins that limit viral gene expression, replication, and spread in the host (24, 34, ...IFN-regulated gene expression also ...
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The Epstein-Barr Virus SM Protein Induces STAT1 and Interferon-Stimulated Gene Expression
... Is STAT1 induction a defensive cellular response to SM, or is it advantageous to viral replication? Although several of the ISGs, particularly those belonging to the ISG56K family, are among the genes most highly induced ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... an interferon (IFN)-inducible host restriction factor that inhibits the release of many enveloped viruses and functions as a negative-feedback regulator of IFN production by plasmacytoid dendritic ...IRF-7 ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... protein gene expression was found to be downregulated (6, ...target gene profiles also dem- onstrates that the constitutively active form of IRF-3 in com- bination with microarray technology is a ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... cellular interferon regulatory factors (IRFs), known as viral IRFs (vIRFs), participate in evasion of the host interferon (IFN) ...feron-stimulated gene 15 (ISG15) E3 ligase, HERC5, in the ...
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Interferon-stimulated gene 15 in hepatitis B-related liver diseases
... IFN-stimulated gene factor 3 (ISGF3) is composed of phosphorylated forms of STAT1, STAT2 and interferon regulatory factor 9 ...to interferon (IFN)-stimulated ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... human interferon (IFN) regulatory factor 3 ...the 3⬘ polyadenylate tail, according to the published sequence for human IRF-3 (4) (GenBank accession ...transcription factor that ...
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Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
... of interferon-stimulated genes (ISGs), whose cumulative action can potently inhibit the replication of ...that gene expression from all 3 viral segments is strongly inhibited by ...viral ...
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The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses
... ) Effects of 3C variants on Sendai virus-induced IFN-  promoter activation. 293T cells were transfected as described for panel B. At 24 h after transfection, cells were then stimulated with Sendai virus for 24 h, ...
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Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products.
... The transcriptional induction of ISGs seen after viral infection could be due to the action of a newly made viral or cellular protein even including interferon itself.. Therefore transcr[r] ...
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Viruses and the interferon (IFN) response : methods to improve production and to rapidly select IFN sensitive viruses for vaccine development
... pol gene encoding enzymes for replication (Zufferey et ...the gene of interest as well as all the necessary elements to allow the delivery of the gene including: long terminal repeats regions (LTRs), ...
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Pegylated leptin antagonist with strong orexigenic activity in mice is not effective in chickens
... were stimulated with human leptin and with interferon αA (IFNA2), both activating the reporter gene through the cLEPR or an endogenous IFNR, respectively (Hen et ...reporter gene in the ...
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Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells
... antiviral agent currently licensed for the treatment of severe RSV lower respiratory tract infections. Because ribavirin treatment reduces the cytopathic effect in infected cells, we used high-density microarrays to ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factors (vIRFs), vIRF1 to vIRF4, which are homologous to cellular IRFs, which are clustered within one genomic locus ...host interferon response and control cellular growth, ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
...  gene represents the primary response to virus infection (13, 16, ... gene requires the consti- tutively expressed transcription factor interferon regulatory factor 3 ...
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Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
... I interferon associated diseases, the ex vivo induction of IFI27 in whole blood from healthy donors was rela- tively weak compared to the other ISGs, and fivefold lower when compared to patients ...differential ...
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IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10
... were performed using the SensiFast Probe No-ROX One-Step kit (Bioline USA Inc., Taunton, MA), and reactions were run on a Stratagene Mx3005P real-time thermocycler (Agilent Technologies, Santa Clara, CA). Primers and ...
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Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo
... 100-fold) following IFN stimulation (4, 7, 19, 20). It is ex- pressed in a variety of cell types at low levels and induced within 6 h of stimulation with IFN- ␣ /  , and to a lesser degree by IFN- ␥ (26). ISG15 has two ...
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Identification of three new cis regulatory IRF5 polymorphisms: in vitro studies
... this 3’ T-vector were ligated to 25 μg of the PCR amplicon in a 10- μ l reaction with 1 μ l of T4 DNA ligase reaction buffer (New England Biolabs, Ipswich, MA, USA) and 1× ligase buffer at 16°C ...
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