Interleukin-12 (IL-12)
Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques
... adjuvants, interleukin-12 (IL-12) and IL-28B, for their effects on the Th1/Th2 axis during vac- cination and 3 months after the final immunization to deter- mine what the short-term and ...
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Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors
... cytokines interleukin-12 (IL-12), IL-18, or gamma interferon (IFN- ␥ ..., IL-12, or both IL-12 and ...the IL-12 and IL-18 genes ...
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Mechanisms by Which Interleukin 12 Corrects Defective NK Cell Anticryptococcal Activity in HIV Infected Patients
... that interleukin-12 (IL-12) restores the activity at least partially through restoration of ...how IL-12 restores the function was ...with IL-12 reversed the ...
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Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I
... normal interleukin- 12/23/gamma interferon (IL-12/23/IFN- ␥ ) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 ...
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Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control
... by interleukin-12 (IL-12), which in concert with the related cytokine IL-23, participates in regulating both innate and adaptive immune responses (15, 18, 26, 31, ...49). ...
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Interleukin-12 is not essential for silicosis in mice
... the IL-1 family that augments the activity of IL-12 in the generation of T H 1- type immune responses ...with IL-12 to produce this ...[11,12]. IL-18 mRNA abundance was decreased ...
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Gamma Interferon (IFN-γ) and IFN-γ-Inducing Cytokines Interleukin-12 (IL-12) and IL-18 Do Not Augment Infection-Stimulated Bone Resorption In Vivo
... Although the background strains were identical in the IL-12 and IL-18 experiments (C57BL/6) (Fig. 1), a larger absolute resorptive response was observed in the IL-18 mice. It should be noted ...
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Differential Regulation of Interleukin-12 (IL-12)/IL-23 by Tim-3 Drives TH17 Cell Development during Hepatitis C Virus Infection
... inhibits IL-12 production through the delivery of negative signal- ing to TLR-mediated STAT1 activation in monocytes ...upregulates IL-23 expression by stimulating TLR-mediated STAT3 ...of ...
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Relationship between Plasma Interleukin-12 (IL-12) and IL-18 Levels and Severe Malarial Anemia in an Area of Holoendemicity in Western Kenya
... Since IL-12 is involved in directly activating protective immunity against both liver stage and blood stage parasites, a severe defect in the IL-12 response could directly affect protective ...
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Interleukin 12 at the site of disease in tuberculosis
... heterodimeric IL-12, we found that mean concentrations were 585 +/- 89 pg/ml in pleural fluid of patients with tuberculous pleuritis, which were significantly higher than those in serum of the same patients ...
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STAT4 Is Required for Antibacterial Defense but Enhances Mortality during Polymicrobial Sepsis
... of interleukin-12 (IL-12), leading to the production of gamma interferon, induction of a T helper type 1 response, and increased natural killer cell ...
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Original Article The expression levels of interleukin-6 (IL-6), IL-12, and matrix metalloproteinase-13 (MMP-13) in the synovial fluid and synovium in hip osteoarthritis and their relationship with disease progression
... of interleukin-6 (IL-6), interleukin-12 (IL-12), and matrix metal- loproteinase-13 (MMP-13) in the synovial fluid and synovium in hip osteoarthritis and their relationship with ...
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Interleukin 27 polymorphisms in HCV RNA positive patients: is there an impact on response to interferon therapy?
... Polymorphism; IL-27: Interleukin 27; IL-12: Interleukin 12; EBI3: Epstein-Barr Virus-Induced Gene 3; JAK: Janus Kinase; STAT: Signal Transducer and Activator of Transcription; ...
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Role of Interleukin-4 (IL-4), IL-12, and Gamma Interferon in Primary and Vaccine-Primed Immune Responses to Friend Retrovirus Infection
... as interleukin-12 (IL-12) and gamma interferon (IFN- ␥ ), which promote T helper type 1 responses, and IL-4, which promotes T helper type 2 ...mice. IL-4- and ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... nity, and, therefore, has important effect on the prognosis of sepsis [11, 12]. The immune func- tion of spleen depends on the synergistic effect between spleen dendritic cells (DC) and immu- nocytes including ...
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Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β
... It is reported that Cur conjugation (e.g., glucuronida- tion) occurs in the liver and intestines [26, 27]. Pip re- portedly inhibits liver and intestinal glucuronidation activity possibly due to the presence of a ...
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Cross regulatory roles of interleukin (IL) 12 and IL 10 in atherosclerosis
... that IL-12 is a major de- terminant in the development of a T helper type 1 cytokine re- sponse (2, ...of IL-12 versus IL-10 correlates with the clinical manifestation of the infection ...
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<p>HMGB1/CXCL12-Mediated Immunity and Th17 Cells Might Underlie Highly Suspected Autoimmune Epilepsy in Elderly Individuals</p>
... including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1, were measured by enzyme-linked immuno- sorbent assays (ELISAs) using human ELISA kits (Abcam, Cambridge, ...
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Chlamydia trachomatis Mouse Pneumonitis Lung Infection in IL-18 and IL-12 Knockout Mice: IL-12 Is Dominant over IL-18 for Protective Immunity
... nous IL-18 in the resolution of lung MoPn in- fection using gene knockout ...of IL-18 was associated with a moderate reduction in systemic and lung IFN- produc- tion, slightly more severe inflammatory reac- ...
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Groß, Simone Ingrid (2017): Strategien zur Subklassifizierung Guillain-Barré-artiger Polyneuropathien bei Hund und Katze. Dissertation, LMU München: Tierärztliche Fakultät
... an IL-12 gekennzeichnet, die die Differenzierung zu TH-1 ...INF-γund IL-12 die Aktivierung der Makrophagen mit anschließendem Myelin-Stripping (ZHANG et ...eines IL-4-Milieus erfolgt ...
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