Interleukin-2 receptor gamma
Partial loss of interleukin 2 receptor gamma function in pigs provides mechanistic insights for the study of human immunodeficiency syndrome
... disrupting interleukin 2 receptor gamma (IL2RG) [18, 19], autosomal Rag-1/2 [20], and RAG-2 SCID [21] or by natural breeding ...
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An interleukin 2 receptor gamma chain mutation with normal thymus morphology
... Potentially, mutation of any component of the IL-2R com- plex could result in immunodeficiency. However, the most commonly observed form of human severe combined immu- nodeficiency (SCID) results from mutations of the ...
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RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus
... gene, interleukin-2 receptor gamma chain (IL- 2Rγc), a gene in which defects are responsible for X-linked severe combined immuno-deficiency (X-SCID), as well as the human interleukin-15 ...
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Interleukin 2 and gamma interferon production, interleukin 2 receptor expression, and DNA synthesis induced by tularemia antigen in vitro after natural infection or vaccination
... The T-ceHl response induced by Francisella tularensis antigen in sensitized subjects was characterized in vitro by measuring DNA synthesis in whole-blood and mononuclear cell cultures, i[r] ...
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Serum Levels of Interleukin-2 and Interleukin-2 Soluble Receptor in Patients with Vitiligo
... Interleukin 2 (IL-2) was discovered in 1976 as a growth factor for T lymphocytes [3]. Since that time it has become an important mediator of immune function though its effects on the growth, ...
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Genome of Deerpox Virus
... including gamma interferon receptor (IFN- ␥ R), interleukin 1 receptor (IL-1R), and type 8 CC-chemokine receptors; cytokine binding proteins (BP), including IL-18BP, IFN- ␣ /  BP, and tumor ...
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Interferon Gamma (IFN-γ) and Soluble Interleukin-2 Receptor (sIL-2R): Combined Diagnostic Markers of Tuberculous Pleural Effusion
... Recently, a commercially available assay from Cepheid (Gene Xpert MTP/RIF, nested real time PCR) is an advance in the field of Mycobacterium tuberculosis (MTB) diagnosis. It can also identify common rifampicin (RIF) ...
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Activation of T lymphocytes in dengue virus infections High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon gamma in sera of children with dengue
... IL-2 receptor (sIL- 2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-gamma (IFN gamma) in the sera of 59 patients with DHF and 41 patients ...
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Impact of heart rate variability, a marker for cardiac health, on lupus disease activity
... IL-1β, interleukin (IL)-1 receptor an- tagonist (IL-1RA), IL-15, IL-17A, IL-21, tumor necrosis factor (TNF)-α, soluble tumor necrosis factor receptors I and II (sTNFRI/II), soluble CD40L (sCD40L), BLyS, ...
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T cell subpopulations, expression of interleukin 2 receptor, and production of interleukin 2 and gamma interferon in human American cutaneous leishmaniasis
... Leukocyte subpopulations, the expression of the interleukin-2 IL-2 receptor, and the production of IL-2 and gamma interferon IFN--y were studied in the peripheral blood mononuclear cells[r] ...
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Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection
... Markers in stimulated plasma. One of our Mtb pathogen-specific SOMAmers robustly detected a peptide of the ESAT-6-like protein EsxB (also known as CFP10) in all supernatants from the stimulated tubes only (see Fig. S2). ...
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Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein
... Generation of polyclonal antiserum and Western blotting. A rabbit polyclonal antiserum was raised against purified IrmA using four immu- nizations (400-g recombinant protein/dose) at the Walter and Eliza Hall Institute ...
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Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.
... LTR transcriptional activity obtained by using NXS mutants in Jurkat cells Spl, TATA, LBP-1, UBP-2 a NRE, Negative regulatory element; IL-2, interleukin-2; IL-2Ra, interleukin-2 receptor[r] ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... specific receptor which is outlined in ...a receptor-docking site for signal transducers and activators of transcription (STAT)-1 and ...to gamma-activated sequences (GAS) or interferon-stimulated ...
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Interleukin 2 and interleukin 2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
... The production of IL-1 and IL-6 by pituitary cells has recently been demonstrated. In this study we investigated the expression of IL-2 and its receptor (IL-2R) by pituitary cells of different species. In ...
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Response to Superantigen Stimulation in Peripheral Blood Mononuclear Cells from Children Perinatally Infected with Human Immunodeficiency Virus and Receiving Highly Active Antiretroviral Therapy
... currently available, a reservoir of HIV exists during HAART (6), and this reservoir provides a mechanism for the lifelong persistence of virus (7). In fact, evidence exists for continuing HIV transcription in patients ...
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The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
... Several studies have demonstrated the presence of CC chemokines in human ILD [43]. Elevated levels of macrophage inflammatory protein (MIP)-1 α /CCL3 have been associated with both sarcoidosis and IPF [43]. Fur- ...
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Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
... production, as well as cell surface and soluble forms of IL-2R. IL-2R gene expression was inhibited for at least 72 h after exposure of cells to dexamethasone. In the presence of exogenous IL-2, dexamethasone ...
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Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... The current pathogenesis of severe sepsis and septic shock is described as a complex interaction of pro- and anti-inflammation, coagulation, and apoptosis triggered by the infecting microorganism. The bacteria outer ...
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Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross sectional study
... In eight synovial tissues obtained from HTLV-I carriers, six samples, including two IgM-positive carriers, showed his- topathological features that are often observed in late- stage OA: synovial lining cells were ...
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