• No results found

intestinal epithelial cell-specific mammalian target of rapamycin complex 1

Inhibition of mammalian target of rapamycin induces phenotypic reversion in three dimensional cultures of malignant breast epithelial cells

Inhibition of mammalian target of rapamycin induces phenotypic reversion in three dimensional cultures of malignant breast epithelial cells

... breast epithelial acini, which is schematically de- scribed in Figure ...(Figure 1(c)) and that lacked contact with the ...breast epithelial cells were initially cultured in a MEGM-based medium ...

8

NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells

NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells

... cancer cell apoptosis ...promote cell growth by increas- ing glucose ...carcinoma cell aggressive phenotype. Block- ing CPT1a results in cancer cell death and ...

12

West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression

West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression

... in 1 ⫻ PBS, pelleted at 3,000 ⫻ g for 5 min, resuspended in lysis buffer consisting of 1% Triton-X, 10 mM triethanolamine-HCl, 150 mM NaCl, 5 mM EDTA, 1 mM methanesulfonyl fluoride, 1 ⫻ Halt ...

14

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

... during cell disruption and fractionation, it is clear that Rag that remains lysosomally associated, like the bulk of cellular Rag, exhibits high, amino acid-independent GTP ...LAMTOR complex, including ...

19

The use of everolimus to target carcinogenic pathways in a patient with renal cell carcinoma and tuberous sclerosis complex: a case report

The use of everolimus to target carcinogenic pathways in a patient with renal cell carcinoma and tuberous sclerosis complex: a case report

... sclerosis complex (TSC) is an autosomal dom- inant disease that was first described by Bourneville in 1880 ...active mammalian target of the rapamycin (mTOR) signaling, so mTOR inhibitors have ...

5

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

... of rapamycin on ECM. Rapamycin is an at- tractive candidate for therapy, as it has proven to be an effective means of suppressing immune responses ...of rapamycin as an immunosuppressant is likely ...

17

Regulation of signalling circuitry downstream of mTORC1(mammalian target of Rapamycin)

Regulation of signalling circuitry downstream of mTORC1(mammalian target of Rapamycin)

... A third level of eIF4E regulation is through its interaction with a family of inhibitory binding proteins. Using the Far-Western hybridization technique [63] isolated cDNAs encoding two small (12 kDa) proteins which ...

17

Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1)

Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1)

... . Rapamycin exposure led to reduced abundance for proteins involved in this process, thus contributing to a protein overload in ER due to a decreased capacity to cope with unfolded proteins, ultimately leading to ...

11

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

... of cell types [23] ...GT1-7 cell line to investigate the interaction be- tween anorexigenic (leptin and insulin) and orexigenic (ghrelin) hormone signalling on mTORC1 activity and mouse hypothalamic ...

14

EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells

EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells

... an epithelial type high-affinity anionic amino acid transporter, and glutamate is the major oxidative fuel for intestinal epithelial ...and cell proliferation through activation of the ...

12

Characterisation of PLD activity in real time

Characterisation of PLD activity in real time

... and cell lines and both isoforms are commonly co-expressed (although this is not always the case – Meier et ...in mammalian tissues and cell lines has been analysed primarily using mRNA levels owing ...

354

Phosphoinositide 3 kinase and the mammalian target of rapamycin pathways control T cell migration

Phosphoinositide 3 kinase and the mammalian target of rapamycin pathways control T cell migration

... inhibitor rapamycin, which is widely used clinically as an immunosup- ...that rapamycin suppressed immune responses because of the role for mTOR as a nutrient sensor that controls protein synthesis and ...

9

Autophagy, cancer and angiogenesis: where is the link?

Autophagy, cancer and angiogenesis: where is the link?

... Background: Autophagy is a catabolic process for degradation of intracellular components. Damaged proteins and organelles are engulfed in double-membrane vesicles ultimately fused with lysosomes. These vesicles, known as ...

10

Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway

Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway

... Abstract: Puerarin, a major isoflavone in radix puerariae, exerts remarkable pharmacological effects on ischemic stroke patients in the clinic. However, the underlying mechanisms of the protective effects of puerarin are ...

11

Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

... contained 1 × SYBR Green Master Mix, ...the target gene was expressed as a fold increase or decrease relative to the expression of ...the target gene and the Ct value of ...

13

Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma

Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma

... Mantle cell lymphoma (MCL) is a rare and aggressive subtype of lymphoma associated with a poor ...The mammalian target of rapamycin (mTOR) is responsible for integrating cell signals ...

12

Immunohistochemical evaluation of p-mTOR (Phosphorylated Mammalian Target of Rapamycin) in oral squamous cell carcinoma

Immunohistochemical evaluation of p-mTOR (Phosphorylated Mammalian Target of Rapamycin) in oral squamous cell carcinoma

... This st ud y was conduct ed on the archival ret rieved formalin fixed, paraffi n embedded tissues obt ained from the Departm ent of Oral Pathology, Adhiparasakthi Dent al C ol lege and Hospital, M elm aruvat hur and from ...

88

Transepithelial d glucose and d fructose transport across the American lobster, Homarus americanus, intestine

Transepithelial d glucose and d fructose transport across the American lobster, Homarus americanus, intestine

... different cell types: E, F, R, B and M cells (Verri et al., 2001). The cell types differ in structure and, as a result, play different roles in digestive and absorptive functions (Verri et ...of ...

8

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

... the mammalian stress-activated pro- tein kinase interacting protein (mSIN1) and protein observed with Rictor-1 ...trol cell size, cell cycle progression [27], and endothelial cell ...

8

N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells

N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells

... regulating cell growth and metabolism, dysregulation of the mTOR signaling is commonly observed in human cancers ...are rapamycin and its analogs (also referred as rapalogs), which are currently used with ...

12

Show all 10000 documents...

Related subjects