Intron Evolution
Intron Evolution and Information processing in the DNA polymerase α gene in spirotrichous ciliates: A hypothesis for interconversion between DNA and RNA deletion
... Macronuclear copies of the DNA polymerase alpha gene from nine phylogenetically-diverse spirotrich ciliates have been analyzed here, including two new sequences for this study. The authors analyzed RNA transcripts from ...
15
Selective Constraints on Intron Evolution in Drosophila
... generated by maximum likelihood (Huelsenbeck and Ronquist 2001). Using this method, the posterior prob- ability of the above clade is 64%. None of the above methods support the traditional phylogeny with proba- bilities ...
10
Constraints on intron evolution in the gene encoding the myosin alkali light chain in Drosophila.
... To distinguish the past action of evolutionary forces in introns known to have regulatory information, we examined nucleotide sequence variation at 991 sites in a r[r] ...
10
Cusimano, Natalie (2011): The Araceae as a Study System: Intron Evolution, Diversification Analyses, and Evolutionary Classification. Dissertation, LMU München: Fakultät für Biologie
... universal, intron in the cox1 gene of Araceae and other ...cox1 intron loss, the first such case documented in the ...the intron has been present in the Araceae for at least 70 million ...cox1 ...
211
Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content
... DNA. Intron size is one possible factor that may explain these con- flicting ...of intron lengths in ...minimal intron length and a broader distribution of longer introns (median intron size ...
8
Orthology confers intron position conservation
... assigning intron positions in the genomic sequence is not a trivial ...the intron loss/gain patterns or in rates for different lineages ...during evolution [14], although this has been shown to be a ...
13
Abstract
... dosage scheme) is a profitable therapy compared with therapy with interferon alpha−2b plus ribavi− rin or with lack of treatment in patients infected with all HCV RNA genotypes. Treatment with peg− interferon alpha−2b ...
10
Analysis of CACTA transposases reveals intron loss as major factor influencing their exon/intron structure in monocotyledonous and eudicotyledonous hosts
... an intron is retained in the transcript ...the intron with its flank- ing exons and therefore the shifting of an annotated boundary in the ...an intron lost by ...for intron loss, it would ...
15
Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript.
... the intron or the first exon were used to map the different transcripts from the LAT locus ...LAT intron, upstream of the lambda phage ...accumulated intron was also visible, although with a ...
12
Estimation of genetic distances from human and mouse introns
... of evolution in the mammalian genome has mostly been studied using ...conserved intron regions (as well as, more strongly, nonsynonymous sites), but if there ...
7
Intron Size and Exon Evolution in Drosophila
... sons for this are unclear. Intron size is influenced by alleles can be combined together to generate the opti- various factors (Comeron 2001; Duret 2001): the inser- mal genotype. A similar argument can be made ...
6
Trichinella pseudospiralis vs T spiralis thymidylate synthase gene structure and T pseudospiralis thymidylate synthase retrogene sequence
... an intron located 12 nt downstream, and ...Trichinella intron 3, animal (with the excep- tion of ...conserved intron, corresponding to Trichinella intron ...homologous intron, ...
10
Intron Definition Is Required for Excision of the Minute Virus of Mice Small Intron and Definition of the Upstream Exon
... small intron in its natural context is ...small intron, the branch point for the rare mRNA form (D1/A2) is upstream of A1, this arrangement would be quite unusual and may affect the effi- ciency of its ...
10
Evolutionary significance and diversification of the phosphoglucose isomerase genes in vertebrates
... A phylogenetic tree was reconstructed using protein sequences of PGI genes of species belonging to the main vertebrate lineages. The protein sequences of all PGI isoforms identified in vertebrate species were aligned ...
16
Identifying the mechanisms of intron gain: progress and trends
... undergone intron transposition [25] and, while they were spliced efficiently, they were shown to rapidly degenerate into normal spli- ceosomal introns, indistinguishable from their original source ...throughout ...
10
Polymorphism in the third intron of the interferonγ gene is associated with susceptibility to multiple sclerosis.
... third intron of the IFN-γ gene and their influence on susceptibility to multiple ...IFN-γ intron III at the +2118 A/G and +3586 G/ACT sites were detected using polymerase chain reaction-restriction fragment ...
6
Genetic repair Bruce A Sullenger, Series EditorRibozyme mediated revision of RNA and DNA
... Exciting progress has been made in the design and engineering of Group II introns that can be inserted into new target sites. However, seminal questions remain unanswered with respect to using retargeted Group II introns ...
8
iMAGA: INTRON MULTIPLE ALIGNMENT USING GENETIC ALGORITHM
... Multiple sequence alignment (MSA) is one of the multi-dimensional problems in biology. This paper describes a new approach to solve MSA, a NP-hard problem using modified Genetic Algorithm with new mutation operator. A ...
10
Combined gene therapy of siRNA and apoptosis inducing factor generated from a single transcriptional event
... Following the verification of EM22-intron plasmids splicing, siRNA sequences for known cancer related genes, such as HPV E6, EGFR, VEGF, and control scramble, were inserted into our EM22-intron plasmid. ...
35
Identification of S genotypes of sweet cherry cultivars from Central and Eastern Europe
... amplifying intron I, it was impossi- ble to distinguish the alleles S 4 from S 6 , S 1 from S 5 , and S 2 from S 9 , which confirms the results obtained for sweet cherry cultivars from Turkey and Croatia (Ipek et ...
9