• No results found

IRF-1

Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription

Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription

... however, IRF-2 lacks a strong transactivation domain in its C terminus and acts as an inhibitor of IRF-1-mediated transcrip- ...of IRF-2 deletion mutants to inhibit IRF-1 ...

7

Interferons and IRF-1 Induce Expression of the Survival Motor Neuron (SMN) Genes

Interferons and IRF-1 Induce Expression of the Survival Motor Neuron (SMN) Genes

... To characterize the molecular basis of IFN- induction of SMN and SMNc genes, nuclear protein extracts prepared from untreated cells and from cells stimulated for 2 hr with IFN- or IFN- were utilized for electromobility ...

12

HIV 1 Tat Recruits HDM2 E3 Ligase To Target IRF 1 for Ubiquitination and Proteasomal Degradation

HIV 1 Tat Recruits HDM2 E3 Ligase To Target IRF 1 for Ubiquitination and Proteasomal Degradation

... and IRF-1-linked polyubiquitination chains were detected using antibodies specific for K48- or K63-linked ubiquitin, ...K48-linked IRF-1 ubiquitination FIG 1 Tat affects ...

13

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR induced IRF 1 and IRF 8 activation and IL 12 production and enhances IL 10 through MAPK activation in dendritic cells

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR induced IRF 1 and IRF 8 activation and IL 12 production and enhances IL 10 through MAPK activation in dendritic cells

... Abstract: Adenylate cyclase toxin (CyaA) of Bor- detella pertussis binds to CD11b/CD18 on macro- phages and dendritic cells (DC) and confers viru- lence to the bacteria by subverting innate immune responses of the host. ...

10

Molecular Cloning and Functional Analysis of IRF-1 in the Asian Swamp Eel (Monopterus albus)

Molecular Cloning and Functional Analysis of IRF-1 in the Asian Swamp Eel (Monopterus albus)

... Complete IRF-1 cDNA sequence and genomic DNA sequence of ...The IRF-1 gene, named maIRF1, spanned ...with IRF-1 in Mandarin (Siniperca chuatsi), Crucian carp (Carassius auratus), ...

10

Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma

Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma

... capability. IRF-1 lies immediately upstream of PD-L1 in the IFN γ -driven JAK/STAT signaling cascade [17], and has been shown to play a central role in regulating cancer cell ’ s response to IFN γ ...

9

Suppression of Growth by All-trans Retinoic Acid Requires Prolonged Induction of Interferon Regulatory Factor 1 in Cervical Squamous Carcinoma (SiHa) Cells

Suppression of Growth by All-trans Retinoic Acid Requires Prolonged Induction of Interferon Regulatory Factor 1 in Cervical Squamous Carcinoma (SiHa) Cells

... Induction of IRF-1 mRNA and the consequent growth in- hibition in cervical squamous carcinoma cells by ATRA have been demonstrated (7). Clinically, retinoids reversed or sup- pressed low-grade or moderate- ...

5

Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells

Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells

... in IRF-1-deficient and -profi- cient MHV68-infected primary ...macrophages. IRF-1 can induce expression of IFN-␤, a member of an extensive family of cytokines that engage a unique type I IFN ...

12

Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication

Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication

... in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ macrophages, we observed IFN-␣4 and IFN- ␤ mRNA induction in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ dendritic cells, especially at later time ...examined, IRF-3 ⫺/⫺ ⫻ ...

9

Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.

Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.

... the IRF-related cDNAs that we iso- lated in our yeast one-hybrid screen encode a novel protein, IRF-7, that binds specifically to ...level, IRF-7 is most closely related to IRF-3 (32% identity ...

11

Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis

Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis

... repressed IRF-1 ...ng IRF-1 luciferase reporter, 25 ng IRF-1 expression plasmid, and titrating amounts of FLAG-HBZ, FLAG–APH-2, or the control expression vector, as ...with ...

13

Mycobacterium avium infection induces the resistance of the interferon-γ response in mouse spleen cells at late stages of infection

Mycobacterium avium infection induces the resistance of the interferon-γ response in mouse spleen cells at late stages of infection

... as 1 day after infection, and the KSL population returned to normal at 7 days postinfection ...because IRF-1/PU-1 induction by IFN-γ exposure induces impaired erythropoiesis ...The ...

8

Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1

Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1

... 3A). IRF-7 expression plasmids and IRF-7 antibody have been described ...Ting). IRF-7DN (amino acids [aa] 1 to 12 and 103 to 503) is a gift from Tom Maniatis ...full-length IRF-7A into ...

10

Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region

Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region

... overlapping IRF-E motifs, one NF-␬B binding motif, and a 13-nucleotide spacer sequence which separates these IRF-E and NF-␬B ...both IRF-E and NF-␬B motifs are essential elements of the ...

12

Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7

Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7

... Human IRF-7 protein is a stable protein. It has recently been reported that IRF-7 is an unstable protein with a half-life of less than 1 h ...Because IRF-7 protein levels did not change ...

9

Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells

Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells

... interleukin 1 ␤ [IL-1 ␤ ], IL-6, IL-8, MCP-1, MIP-1 ␣ , and MIP-1 ␤ ) was detected at either the protein or message level in hantavirus-infected ...of IRF-1 and ...of ...

16

Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells

Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells

... of Irf-1 expression significantly depresses the proliferation of VSMCs under high glucose ...conditions. Irf- 1 has also been shown to be a positive regulator of the high glucose-induced ...

13

Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors

Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors

... the IRF adjuvants for the subdominant HA epitope than for the immunodominant NP epitope ...of IRF-1 had weaker effects on T-cell ...and IRF-1 were equimolar rather than ...

8

Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling

Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling

... single IRF binding site in the BST2 promoter is sufficient to elicit activation by type I ...IFN. IRF proteins can induce BST-2 upregulation in the absence of type I IFN ...of IRF-E binding sites in ...

15

Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus

Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus

... of IRF-1 in B cell differentiation was previously poorly ...vitro, IRF-1 can bind to the same regulatory sites as Blimp-1 (34); however, the relevance of this observation has not been ...

12

Show all 10000 documents...

Related subjects