Iron-Manganese superoxide dismutase
Extracellular and Cytosolic Iron Superoxide Dismutase from Mycobacterium bovis BCG
... the superoxide radical is a normal product of the univalent reduction of molecular oxygen, SODs are thought to be the primary defense against its potential cytotoxicity ...site. Manganese-containing SODs ...
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A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron
... the manganese cofactor. We observed an extra water between the manganese, Y34 and H30, with respect to the native ...the superoxide substrate passes to reach the active ...the manganese to a ...
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Escherichia coli superoxide dismutase expression does not change in response to iron challenge during lag phase: Is the ferric uptake regulator to blame?
... intracellular iron levels to meet metabolic needs yet mitigate iron cytotoxicity ...an iron (II)- dependent suppressor of iron uptake proteins ...regulates superoxide dismutase ...
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The protective role of manganese superoxide dismutase against adriamycin induced acute cardiac toxicity in transgenic mice
... generate superoxide radicals (for review see references 3 and ...that superoxide is generated through redox cycling of ADR in vivo. Superoxide radicals can react with hydrogen peroxide to form highly ...
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Raising the antioxidant levels within mouse muscle fibres does not affect contraction induced injury
... antioxidants manganese superoxide dismutase, copper zinc superoxide dismutase or catalase in transgenic mice, the force deficits 3 days following the administration of a 75 LCP to in ...
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Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors
... and manganese superoxide dismutase (SOD2) in non-stimulated NK cells of the oldest seniors ( n = 25; aged over 85; mean age 88 years) and compare with NK cells of the old ( n = 30; aged under 85; ...
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Tolerance of rats to hyperoxia Lung antioxidant enzyme gene expression
... dismutase (MnSOD) activity fell approximately 50% despite a threefold increase of MnSOD mRNA concentration; addition of a reducing agent to lung extracts from O2-exposed rats partially restored MnSOD activity. ...
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Gene Polymorphisms of Tumor Necrosis Factor Alpha and Antioxidant Enzymes in Bronchial Asthma
... dismutase (MnSOD) gene is located at amino ac- id position 16 in the mitochondrial targeting se- quence (MTS) resulting in the replacement of an al- anine with a valine (Ala16Val). This polymorphism has been ...
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Antioxidative defense and mitochondrial thermogenic response in brown adipose tissue
... 38. Nilakantan V, Halligan NL, Nguyen TK, Hilton G, Khanna AK, Roza AM, Johnson CP, Adams MB, Griffith OW, Pieper GM (2005) Post-translational modification of manganese superoxide dismutase in ...
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Redox Regulation of Adenovirus-Induced AP-1 Activation by Overexpression of Manganese-Containing Superoxide Dismutase
... Adenovirus gene therapy is a promising tool in the clinical treatment of many genetic and acquired diseases. However, it has also caused pathogenic effects in organs such as the liver. The redox-sensitive transcription ...
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Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction
... Downloaded from thorax.bmj.com on July 12, 2010 - Published by group.bmj.com iii52 Poster presentations have highlighted the difficulty of predicting mortality in this patient group from[r] ...
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Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival
... Background Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents ...
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Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice
... Amputation as a result of impaired wound healing is a serious complication of diabetes. Inadequate angiogen- esis contributes to poor wound healing in diabetic patients. Endothelial progenitor cells (EPCs) normally aug- ...
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Superoxide Dismutase Activity in Leukocytes
... Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay ...that superoxide anion might be involved in the bactericidal ...
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In vivo antioxidant capacity and enzymes of inflammation inhibitory activity of n-butanol fraction from boswelli dalzielii hutch (burseraceae
... also have been reported to be produced by radiation, bacterial and viral toxin, smoking, alcohol, and psychological or emotional stress. Oxygen free radicals induced damage due to peroxidation to bio-membranes and also ...
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Amyotrophic lateral sclerosis: update and new developments
... Copper chaperone for superoxide dismutase co-aggregates with superoxide dismutase 1 (SOD1) in neuronal Lewy body-like hyaline inclusions: an immu- nohistochemical study [r] ...
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Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis associated ovarian cancers
... Mitochondrial superoxide dismutase (SOD2) is an en- zyme that metabolizes superoxide in mitochondria and plays an important role in maintaining mitochondrial function through oxidative stress ...
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Susceptibility of Diabetics with Superoxide Dismutase Gene 2 Polymorphism to Vascular Complications.
... 79. Chenghong Lan,1,2 Pancy O. S. Tam,1 Sylvia W. Y. Chiang,1 Carmen K. M. Chan,1 Fiona O. J. Luk,1 Gary K. Y. Lee,1 Jasmine W. S. Ngai,1 Jason S. S. Law,1 Dennis S. C. Lam,1,2 Chi-Pui Pang,1,2 and Timothy Y. Y. ...
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Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA binding protein
... specific manganese superoxide dismutase (MnSOD) RNA-binding proteins exist, we tested whether protein in rat lung extract would bind to 32P-labeled MnSOD ...
5
Biological Role of Mn-catalase in Select Lactobacilli
... a manganese catalase (Mn-catalase) in ...the manganese catalase gene in Escherichia coli ...the manganese catalase gene, importance of Mn accumulation in a Mn-catalase containing LAB, whose species ...
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