Isolated perfused rat heart
Very Low Density Lipoprotein: METABOLISM OF PHOSPHOLIPIDS, CHOLESTEROL, AND APOLIPOPROTEIN C IN THE ISOLATED PERFUSED RAT HEART
... The fate of rat plasma very low density lipoprotein (VLDL) constituents was determined in the isolated perfused rat heart. VLDL was labeled with [ 14 C]palmitate, 32 P-phospholipids, [ ...
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The Role of Cyclic Adenosine Monophosphate in Adrenergic Effects on Ventricular Vulnerability to Fibrillation in the Isolated Perfused Rat Heart
... The relation between myocardial tissue cyclic AMP (cAMP) and the vulnerability to ventricular fibrillation was assessed in the isolated perfused rat heart by measurement of ventricular ...
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Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model
... to the diet. This confirms results by Bester and co-work- ers (2006) which showed that RPO supplementation could offer protection against ischaemia/reperfusion injury in diets of different fat content when compared to ...
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Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts
... Many studies have been reported on the cardiovascular activity of A. paniculata [20–28] and on other pharmacolog- ical aspects [3–19]. However, no cardiovascular activity study involving a direct effect on the ...
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Effects of Ranolazine on Carbohydrate Metabolism in the Isolated Perfused Rat Liver
... The action mechanism of ranolazine, an antiangina drug, could be at least partly metabolic, in- cluding inhibition of fatty acid oxidation and stimulation of glucose utilization in the heart. The purpose of the ...
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The inotropic effects of ammonia on isolated perfused rat hearts and the mechanisms involved
... were perfused for 20–30min to establish equilibrium ...LVDP, heart rate and coronary flow were maintained at the same level for three continuous periods of measurement, 5min ...
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The purification and metabolism of a mitochondrial high phosphate derivative, oligophosphoglyceroyl-ATP, in rat heart and liver
... in rat liver (lies et al, 1985 and Desmoulin et al, ...in isolated liver mitochondria (Ogawa et al, 1978; Hutson et al, 1989) and in the perfused heart (Humphrey and Garlick, ...from ...
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Low density lipoproteins and haemodynamic changes in the isolated perfused rat kidney
... in perfused kidneys to a level similar to that observed in vivo can be achieved by the introduction o f an emulsified fluorocarbon (FC 43^) as an artificial oxygen carrier (Franke and Weiss ...
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Integration of preclinical and clinical data with pharmacokinetic modeling and simulations to characterize the disposition of orally-active antiparasitic prodrugs and metabolites : prediction of the dose-exposure relationship in humans
... models, isolated perfused livers (IPLs) and sandwich-cultured hepatocytes (SCH) from rats, to characterize and compare the hepatic disposition of pafuramidine/CPD-0868 and derived ...
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Factors Influencing the Handling of Insulin by the Isolated Rat Kidney
... The renal handling of immunoreactive insulin was studied in the isolated perfused normothermic rat kidney to determine a the relative contributions of glomerular clearance and peritubula[r] ...
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The control of vascular tone in pregnancy
... Virgin and first time pregnant, Sprague-Dawley rats, matched for pre-pregnancy weight (271±5g; meamtSEM; University College London), w ere anaesthetised with 60mg kg-^ i.p. pentobarbitone sodium (Sagatal; Rhone Merieux) ...
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Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter
... sulfobromophthalein (BSP) was markedly reduced upon removal of Cl- from the medium. In the present study, unidirectional Cl- gradients were established in short-term cultured rat hepatocytes and their effect on ...
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Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin Kinetics, sidedness, and molecular forms
... Using isolated, in situ, single-pass perfused rat livers, incubations of freshly isolated hepatocytes, and sinusoidal membrane-enriched vesicles, we and others have shown the saturability of ...
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DNA SYNTHESIS IN THE ISOLATED PERFUSED RAT LIVER EUR 308 e
... A liverlobe was removed before the second addition of thymidine and at the end of the perfusion 4-5 hours after the start of the perfusion DNA was isolated from the liversamples, and its[r] ...
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THE ACTION OF IODOACETATE ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF THE ISOLATED PERFUSED FROG HEART
... THE ACTION OF IODOACETATE ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF THE ISOLATED PERFUSED FROG HEART Morris Kleinfeld, … , John Magin, Charles E... THE ACTION OF IODOACETATE ON THE [r] ...
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Bilirubin Diglucuronide Formation in Intact Rats and in Isolated Gunn Rat Liver
... TABLE IV Bilirubin Monoglucuronide and Diglucuronide Excretion in Bile by Isolated Perfused Gunn Rat Liver after Injection of [3HBilirubin Monoglucuronide during Intrahepatic Unconjugate[r] ...
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Control of sodium and potassium transport in the cortical collecting duct of the rat Effects of bradykinin, vasopressin, and deoxycorticosterone
... absorption and potassium secretion in cortical collecting ducts perfused in vitro. Arginine vasopressin causes a reversible increase in net potassium secretion and net sodium absorption. Bradykinin in the ...
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Reactive oxygen species during ischemia reflow injury in isolated perfused rat liver
... The hypothesis that intracellular generation of reactive oxygen species in hepatocytes or reticuloendothelial cells may cause ischemia-reperfusion injury was tested in isolated perfused livers of male ...
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Study of the Biotransformation of Benfluron Using the Isolated Perfused Rat Liver
... The rat liver was perfused in vitro using a modified sur- gical and perfusion technique described previously (8). Animals were anaesthetized with pentobarbital (60 mg/kg) before surgery. Freshly prepared ...
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The Handling of Immunoreactive Vasopressin by the Isolated Perfused Rat Kidney
... kidneys perfused with AVP at concentrations below 116 µU/ml, the organ clearance of AVP (OC AVP ) was 1,145±47 (SE) µl/min, whereas glomerular filtration rate (GFR) averaged 515±37 ...
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