isoniazid, rifampin, pyrazinamide, and ethambutol
Evaluation of the Fully Automated BACTEC MGIT 960 System for Testing Susceptibility of Mycobacterium tuberculosis to Pyrazinamide, Streptomycin, Isoniazid, Rifampin, and Ethambutol and Comparison with the Radiometric BACTEC 460TB Method
... (SM), isoniazid (INH), rifampin (RMP), ethambutol (EMB), and pyrazinamide (PZA) was evaluated with 100 clinical isolates and compared to that of the radiometric BACTEC 460TB (B460) ...
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Totally Drug-Resistant Tuberculosis (TDR-TB): An Overview
... (1949), isoniazid (1952), pyrazinamide (1954), cyclosporine (1955), ethambutol (1962) and rifampicin; ...least isoniazid and rifampin, the two most potent TB ...and isoniazid ...
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Improved Bioavailability of Rifampicin Nanoparticles from Fixed Dose Combination with Isoniazid, Pyrazinamide and Ethambutol.
... Rifampicin After oral administration on an empty stomach, the absorption of rifampicin (rifampin) is rapid and practically complete. With a single 600mg dose it undergoes first passage through the hepatoportal ...
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Detection of Multidrug Resistance in Mycobacterium tuberculosis
... for rifampin (RIF), katG and the mabA (fabG1)-inhA promoter for isoniazid (INH), embB for ethambutol (EMB), pncA for pyrazinamide (PZA), rpsL and rrs for streptomycin (STR), and gyrA for ...
14
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
... To simulate how this approach would per- form in contexts with differing burdens of anti- microbial resistance, we assessed the decline in negative predictive value associated with an in- creasing prevalence of ...
13
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis
... Mycobacterium tuberculosis and other members of the M tuberculosis complex use several strategies to resist the action of antimicrobial agents. First, the mycobacterial cell is surrounded by a specialized, highly ...
5
Multicenter Evaluation of the MB/BACT System for Susceptibility Testing of Mycobacterium tuberculosis
... for rifampin, isoniazid, and pyrazinamide. For ethambutol, sensitivity was ...The rifampin, isoniazid, streptomycin, and ethambutol susceptibility test results were ...
5
Evaluation of Antimicrobial Re sistance of New Cases of Pulmonary Tuberculosis, in Khorasan, Iran
... Table 1 and 2 show Frequency distribution of demographic factors, clinical characteristics, severity of positive sputum smear and other factors affecting tuberculosis in two groups. The group with positive sputum culture ...
7
Pharmacokinetics of anti-tuberculosis drugs in HIV-positive and HIV-negative adults in Malawi
... 2009. Isoniazid, rifampin, ethambutol, and pyrazinamide pharmacokinetics and treatment outcomes among a predominantly HIV-infected cohort of adults with tuberculosis from ...
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Flow Cytometric Testing of Susceptibilities ofMycobacterium tuberculosis Isolates to Ethambutol, Isoniazid, and Rifampin in 24 Hours
... tuberculosis were determined to be susceptible to 0.2 mg of INH/ml by the proportion method, but they were shown to be susceptible to 0.02 mg/ml by the flow cytometric susceptibility tes[r] ...
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Simultaneous Determination of Pyrazinamide, Rifampicin, Ethambutol, Isoniazid and Acetyl Isoniazid in Human Plasma by LC-MS/MS Method
... rifampicin, pyrazinamide, and ethambutol) and one major metabolite (acetylisoniazid) using high-performance liquid chromatography/tandem mass spectrometry ...
13
Testing of Mycobacterium tuberculosis susceptibility to ethambutol, isoniazid, rifampin, and streptomycin by using Etest
... (ethambutol, isoniazid, rifampin, and streptomycin) and reliance on a single critical concentration of an antimicrobial agent for susceptibil- ity ...
5
Simplified Microarray System for Simultaneously Detecting Rifampin, Isoniazid, Ethambutol, and Streptomycin Resistance Markers in Mycobacterium tuberculosis
... We developed a simplified microarray test for detecting and identifying mutations in rpoB, katG, inhA, embB, and rpsL and com- pared the analytical performance of the test to that of phenotypic drug susceptibility ...
8
Multicenter Laboratory Evaluation of the MB/BacT Mycobacterium Detection System and the BACTEC MGIT 960 System in Comparison with the BACTEC 460TB System for Susceptibility Testing of Mycobacterium tuberculosis
... In studies described in previously published papers, discrep- ancies between results from the evaluated methods were re- solved by means of reanalysis with the two methods (12) or with the proportion method on Lo ...
5
Factors associated with isoniazid resistant tuberculosis among human immunodeficiency virus positive patients in Swaziland: a case control study
... The dependent variable, drug-resistant status, was di- vided into 3 groups, HR-TB or PDR-TB, MDR-TB, and DS-TB. We combined HR-TB and PDR-TB as one group since isoniazid and rifampicin were the most powerful ...
8
Latent Tuberculosis Infection in Children: A Call for Revised Treatment Guidelines
... of isoniazid, is both more expensive and less effective than ...rifampin. Rifampin should be considered for children with latent TB infec- tion when the risk of isoniazid resistance exceeds ...
9
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
... [RMP], isoniazid [isonicotinic acid hydrazide] [INH], ethambutol [EM]), pyrazinamide [PZA]), with streptomycin (SM) more commonly used when treatment ...
13
Comparative Study of Herbal Extract of Piper Nigrum, Piper Album and Piper Longum on Various Characteristics of Pyrazinamide and Ethambutol Microspheres
... In-vitro drug release: Dissolution studies were carried out using USP XXIV rotating basket method. The release profiles of pyrazinamide and Ethambutol from microspheres were studied in simulated gastric ...
7
A Novel Quantitative Method for the Simultaneous Assay of Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), and Pyrazinamide (PYP) in 4-FDC Tablets
... This paper presents the development and validation of a new ultra high performance chromatography (UHPLC) procedure for the simultaneous determination of isoniazid (INH), rifampicin (RIF), pyrazinamide ...
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Enhancement in Stabilityand In-Vivo Bioavailability of Rifampicin Alone and in Combination with Isoniazidusing Ascorbic Acid.
... Rifampicin, Isoniazid, Pyrazinamide, Ethambutol were earlier prescribed as a separate formulation in TB treatment. To increase the patient compliance, the World Health Organization (WHO) and the ...
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