Kaposi sarcoma-associated herpesvirus
The latency associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma
... Kaposi sarcoma–associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman ...
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Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... Kaposi sarcoma–associated herpesvirus (KSHV) is necessary for KS development. KSHV DNA is found in all KS lesions (4, 5). KS prevalence follows KSHV seroprevalence, and in most cases fulmi- ...
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HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... Kaposi sarcoma–associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric ...
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Kaposi sarcoma–associated herpesvirus miRNAs suppress CASTOR1 mediated mTORC1 inhibition to promote tumorigenesis
... complex 1 (mTORC1) upon arginine deprivation. mTORC1 regulates cell proliferation, survival, and metabolism and is often dysregulated in cancers, indicating that cancer cells may regulate CASTOR1 and CASTOR2 to control ...
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Characterization of the K1 protein of Kaposi sarcoma-associated herpesvirus and development of a novel vaccine for protection against rhadinovirus infection
... K1. K1 is a 46-kDa type I membrane glycoprotein encoded by the first open-reading frame (106). K1 is also designated VIP (variable ITAM-containing protein) as it contains an immunoreceptor tyrosine-based activation motif ...
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Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses
... Key words: Human papillomaviruses, Epstein-Barr virus, Kaposi sarcoma-associated herpesvirus, adenovirus, polyomavirus, human T-cell leukemia virus, viral noncoding RNA, viral microRNA,[r] ...
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5557.pdf
... Kaposi Sarcoma (KS) and the plasmablastic variant of multicentric Castleman disease (MCD) are associated with Kaposi Sarcoma associated herpesvirus (KSHV) infection and ...
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New approaches to the treatment of human herpesvirus 8-associated disease.
... Human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus or KSHV) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion lymphoma (PEL), ...
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Kaposi's Sarcoma Associated Herpesvirus Interleukin 6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration
... small interfering RNA (siRNA) and plated the cells on dishes coated with collagen IV as previously described (40). At 40 h post- transfection, cells were serum starved for 8 h. Monolayers were scratched with a P200 ...
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Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma
... Classic KS is characterized by cutaneous lesions dis- tributed mainly on the lower extremities and trunk and often associated with venous stasis, lymphedema or hyperkeratosis [6, 7]. Different therapeutic options ...
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Classic Kaposi Sarcoma in 3 Unrelated Turkish Children Born to Consanguineous Kindreds
... human herpesvirus 8 (HHV-8) in childhood is common in the Mediterranean basin; however, classic Kaposi sarcoma (KS) is ex- ceedingly rare in children not infected with HIV and not receiving im- ...
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Kaposi’s Sarcoma Associated Herpesvirus Increases PD L1 and Proinflammatory Cytokine Expression in Human Monocytes
... KSHV is tropic for monocytes both in vivo and in vitro (35–40). Within KS, the primary tumor is composed of latently infected spindle cells combined with a small subset of lytic cells and inflammatory cell infiltrate. KS ...
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Kaposi’s sarcoma associated herpesvirus G protein coupled receptor activates the canonical Wnt/β catenin signaling pathway
... Transgenic expression of vGPCR in mice is sufficient to induce cell proliferation, spindle cell morphology, angio- genesis and tumorigenesis that leads to formation of le- sions similar to those in Kaposi’s ...
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Kaposi’s Sarcoma Associated Herpesvirus Genome Programming during the Early Stages of Primary Infection of Peripheral Blood Mononuclear Cells
... Previous studies of ORF49 suggested a role in KSHV lytic rep- lication cooperating with RTA to activate lytic transcription through the c-Jun and p38/Jun N-terminal protein kinase (JNK) pathway (39). Here, we showed that ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence
... is associated with deposition of H3K27me3, a bivalent mark representing “poised” heterochromatin that can repress transcription despite the presence of activating modifications, on the promoters of lytic genes ...
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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... Upon activation, p53 is stabilized and induces cell cycle arrest or apoptosis through transcriptional activation of downstream targets (reviewed in reference 30). p53 is among the most frequently mutated genes in human ...
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Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... Human herpesvirus 8 (HHV-8; also known as Kaposi’s sarcoma-associated herpesvirus) is the causative agent of Kaposi’s sarcoma and certain B-cell ...
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... Generalized transcription activity is a local phenomenon, and every cell coordinates the expression of a vast number of genes important for survival as part of its generalized transcrip- tion activity. Survivin gene ...
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Kaposi`s sarcoma associated herpesvirus infection among female sex workers and general population women in Shanghai, China: a cross sectional study
... HSV-2 and syphilis infections but not with KSHV infection. Furthermore, KSHV seropositivity was not associated with syphilis, HSV-2, as well as sexual practices among both FSWs and GW. A significant positive ...
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Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
... Kaposi sarcoma–associated (KS-associated) herpesvirus (KSHV) infection is linked to the development of both KS and several lymphoproliferative ...is associated with cis-acting, ...
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