kinase inhibitors
BCR ABL KINASE INHIBITORS FOR CANCER THERAPY
... tyrosine kinase inhibitors have started era of molecular targeted therapy and marked a greatest milestone in cancer drug ...tyrosine kinase activity of the BCR-ABL fusion protein has been established ...
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Targeting cancer with kinase inhibitors
... the kinase target itself, and the underlying genomic characteristics of the ...a kinase following multiple rounds of targeted therapy suggests that some tumors exhibit a near-obligate dependence on a driver ...
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Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption
... protein kinase inhibitors in acidification of the resorp- tion lacunae and bone resorption by human ...the inhibitors is often not very high, and this is clearly illustrated by the fact that one of ...
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Protein kinase inhibitors in cancer treatment: a review
... tyrosine kinase due to mutation, autocrine-paracrine stimulation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for treatment of ...
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High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease
... that inhibitors targeting pathways known to be important in cyst growth can also prevent cyst swelling in our model, we screened a library of 273 kinase inhibitors (SelleckChem-L1200) with described ...
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An emerging treatment option for glaucoma: Rho kinase inhibitors
... Rho kinase. There exists a general consensus that Rho kinase inhibitors alter actomyosin activity in the TM while exerting minimal toxic effects on the eye and, therefore, may be of thera- peutic ...
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Kinase inhibitors: a new class of antirheumatic drugs
... system, kinase inhibitors show class-specific adverse events that possibly represent off-target ...JAK inhibitors caused elevation of lipid ...
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Marine-derived protein kinase inhibitors for neuroinflammatory diseases
... for kinase inhibitors [68], which could be the third possible future research directions of these marine-derived protein kinase ...protein kinase inhibitors for neuroinflammatory ...
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JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia
... other kinase inhibitors have been developed, including a variety of JAK kinase inhibitors (Table ...these inhibitors are still under development, the JAK1/ JAK2-selective inhibitor ...
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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors
... potent inhibitors of Tg/CpCDPK1 have comparable activ- ity against ...bumped kinase inhibitors (BKIs), which inhibit microgametocyte ...protein kinase 4 and predicted to have little activity ...
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Kinase inhibitors as potential agents in the treatment of multiple myeloma
... molecule kinase inhibitors that take advantage of subtle ATP binding site differences have been developed and are used clinically [225], albeit often accompanied by off- target effects, to treat a number of ...
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Rational Computational Study for New Kinase Inhibitors
... these inhibitors to bind within the active site of the kinases or may contribute to the specific inhibition of the active site of these enzymes for a chlorine- containing inhibitor at that ...
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Role of janus kinase inhibitors in the treatment of alopecia areata
... janus kinase (JAK), and signal transducer and activator of transcription (STAT) (Figure ...tyrosine kinase family, which consists of JAK1, JAK2, JAK3, and tyrosine kinase 2 ...
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Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
... other inhibitors of SK1 and SK2 such as SKi (2-(p-hydroxyanilino)- 4-(p-chlorophenyl) thiazole) induce the proteasomal degradation of SK1 via a mechanism that is only partially dependent on direct binding to SK1 ...
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Protein kinase inhibitors for acute leukemia
... tyrosine kinase (RTK) inhibitor and was proved to target platelet-derived growth factor (PDGF-Rs), vascular endo- thelial growth factor receptors (VEGFRs), and CD117 (c- KIT) receptor tyrosine kinases except for ...
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Combining molecular targeted agents with radiation therapy for malignant gliomas
... tyrosine kinase inhibitors gefitinib and erlotinib, mammalian target of rapamycin inhibitors temsirolimus and everolimus, and integrin inhibitor cilengitide, in combination with radiation therapy, ...
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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells
... tyrosine kinase inhibitors (TKIs) had been developed, some of which, including gefitinib and erlotinib, had been approved by FDA for treatment of NSCLC ...tyrosine kinase domain, thus suppress EGFR ...
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<p>Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells</p>
... tyrosine kinase inhibitor of the BCR-ABL kinase, the clinical approach to CML has dramatically changed, with a stunning improvement in the quality of life and response rates of ...tyrosine kinase ...
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A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space
... low kinase-like categories. High kinase-likeness databases have AUC values near ...Low kinase-likeness databases have AUC values closer to ...Medium kinase-likeness databases have AUC values ...
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Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor library
... selected kinase inhibitors which suppressed CSC formation partially alleviated EMT of breast cancer ...The kinase inhibitors evaluated in this study amelio- rated TGF-β-induced increase in ...
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