Krüppel-like factor 6 (KLF6)
Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling
... Immunoprecipitation; KLF6: Krüppel-like factor 6; Luc: Luciferase; MAPK: Mitogen activated protein kinase; MCK: Muscle creatine kinase; MEF2: Myocyte enhancer factor 2; MEK: MAP ...
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Krüppel like factor 6 regulates transforming growth factor β gene expression during human respiratory syncytial virus infection
... identified Krüppel-like factor 6 (KLF6) as a critical transcription factor required for TGF-b gene-expression during RSV infection of human lung epithelial ...Although ...
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Krüppel like factor 6 regulates mitochondrial function in the kidney
... identified Krüppel-like factor 6 (KLF6), a zinc finger domain transcription factor, as an essential regulator of mitochondrial function in podocyte ...of Klf6 increased ...
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Loss of Krüppel like factor 6 cripples podocyte mitochondrial function
... Second, mice with podocyte-specific deletion of Klf6 manifested albuminuria but not glomerulosclerosis, as least within the observation period (22). Doxorubicin induces podocyte injury and results in ...
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Original Article miR-320 inhibits human coronary artery smooth muscle cell proliferation and migration by targeting Krüppel-like factor 5
... Krüppel-like factor 5 (KLF5) is characterized by a highly conserved interfinger space sequence and has been identified in mammalian [6]. It is generally known that KLF5 regulates a wide ...
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Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
... In addition to the Smad-dependent pathway, TGF-β1 might mediate the many Smad-independent pathways, including JNK, ERK, p38, and PI3K, to exert its signal transduction [19, 20]. Here, we used specific kinase in- hibitors ...
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Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation
... of Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, enhances GEC proliferation in both RPGN and FSGS due to dysregulated STAT3 ...
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The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells
... are small almond shaped structures that are found throughout the body which produce and store infection-fighting cells). II, The cancer is more than 2 centimeters in size, but less than 4 centimeters (less than 2 ...
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Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer
... Our cDNA microarray data indicated that EGFR is potentially one of the highly KLF8-induced genes in the 10A-iK8 cells [29]. EGFR is overexpressed in TNBC cells such as MDA-MB-231 cells that also express aberrantly high ...
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Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
... known to mutate in human beta-thalassemias [1], and restricts megakaryocytic differentiation to the benefit of erythroid differentiation [2]. The EKLF gene dosage is crucial for regulating the surface phenotype and ...
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Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice
... growth factor receptor; FGF-BP: fibroblast growth factor binding protein 1; H&E: hematoxylin and eosin; HR: homologous recombination repair; IF: Immunofluo- rescence assay; IHC: Immunohistochemical ...
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A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
... Krüppel-like factor 8 (KLF8) belongs to the KLF fam- ily of transcription factors, which shares the similar well- conserved zinc finger DNA-binding domains, and plays a critical role in controlling ...
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Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression
... Human KLF4 cDNA was inserted into the pCDH vector using the primers: F:5-GCGAATTC ATGAGGCAGCCACCTGGCGA-3 and R: 5-GCGGA TCC TTAAAAATGCCTCTTCATGT-3. KLF4cDNA was then amplified by RT-PCR using total RNA from MG63 cells. ...
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A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
... Upon further analysis, low KLF4 mRNA levels were detected in most colon cancers, with the exception of Cases 3 and Case 6 (Figure 3C, normalized to GAPDH). Western immunoblotting confirmed the attenuated KLF4 ...
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MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
... growth factor binding protein-1 (IGFBP-1)), inflammatory mediators (IL-1, IL-6, IL-8, and TNF-α), and specific extracellular matrix proteins (laminin, type IV collagen, and fibronec- tin) ...
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Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-β1
... pathways [25]. In breast cancer, KLF4 inhibits epithelial- to-mesenchymal transition through regulation of E-cadherin gene expression [42]. In this study, we demonstrated the expression of KLF4 after TGF-β1 treatment, ...
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Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter
... lium, krüppel-like factor (KLF) 4 and 5 are expressed in post-mitotic keratinizing suprabasal cells and proliferative less-differentiated basal cells, ...
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Krüppel like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development
... For embryonic expression experiments, mRNAs encoding ERG, KLF2, DR- KLF2 and EGFP were injected into a single vegetal blastomere of a four-cell stage embryo in 0.4 ⫻ MMR containing 6% Ficoll and cultured ...
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Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall
... By contrast, targeted disruption in mice of KLF2 revealed its essential role in programming quiescent phenotype of sing- le-positive T cells and in normal development of the lungs. Hence its alternative denomination of ...
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Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
... Inflammation of the CNS is marked by the excessive pro- duction of numerous proinflammatory cyto-chemokines including TNF-a, MCP-1 and IL-6 in response to LPS [3,4]. Previous reports from our laboratory have ...
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