Leptin resistance and obesity
Hypothalamic ER stress: A bridge between leptin resistance and obesity
... 5.1. Causes leading to hypothalamic ER stress-induced leptin resistance 5.1.1. Hypothalamic lipotoxicity High-fat rich diets elicit ER stress, leptin resistance and obesity. But how HFD ...
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Role of leptin resistance in the development of obesity in older patients
... of leptin has brought the long-awaited dream for a potential cure, which could induce satiety and weight loss in obese ...with leptin therapy in most obese individuals was modest compared to expectations, ...
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Two defects contribute to hypothalamic leptin resistance in mice with diet induced obesity
... 2000. Obesity in humans and in rodents is usually associated with high circulating leptin levels and leptin ...for leptin resistance, we determined the ability of leptin to ...
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Leptin resistance contributes to obesity and hypertension in mouse models of Bardet Biedl syndrome
... ing obesity and cardiovascular ...of obesity in these mouse models and found that BBS-null mice were hyperphagic, had low locomotor activity, and had elevated circulating levels of the hormone ...exogenous ...
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Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity
... Crucially however, in humans, low-carbohydrate diets spontaneously decrease weight in a way that low-fat diets do not. Furthermore, nutrition transition patterns and the health of those still eating diverse ancestral ...
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Polymorphism in leptin receptor gene was associated with obesity in Yogyakarta, Indonesia
... Background: Leptin is a hormone that regulates homeostasis energy through the cen- tral–peripheral mechanism as well as regulates hunger and ...satiety. Leptin receptor is important in leptin signal ...
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ENDOCRINOLOGICAL ROLE OF LEPTIN IN OBESITY AND ASTHMA
... that obesity-induced raise in leptin level and leptin resistance would be responsible for worsening asthma symptoms ...serum leptin, TNF-α, and ghrelin level in animals with ...
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Critically Discuss the Revival of Leptin for Obesity Therapy
... to leptin hinders cen- tral and peripheral actions of leptin, including appetite, nutrient intestinal ab- sorption, intermediate metabolism and insulin sensitivity, and subsequently leads to an energy ...
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Estradiol and Leptin in Women with Obesity, Overweight, and Normal Body Weight
... and leptin concen- tration on women with obesity, overweight and normal ...with obesity and over- ...high leptin concentration indicates there is leptin resistance and the low ...
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The Anti-Obesity Potential of Green Tea: The Effect on Leptin and Adiponectin
... on leptin production and the anti- obesity ...Although leptin has shown to reduce body weight in obese individual, there are evidences of leptin ...of leptin failed to reduce weight and ...
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Obesity and the ageing brain : could leptin play a role in neurodegeneration?
... cited. Obesity and ageing are both characteristics of the human population that are on the increase across the ...that obesity is another such factor. Leptin resistance or insensitivity has ...
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Induction of Leptin Resistance by Activation of cAMP-Epac Signaling
... Gaede, P., Lund-Andersen, H., Parving, H.H., and Pedersen, O. (2008). Effect of a multifactorial intervention on mortality in type 2 diabetes. N. Engl. J. Med. 358, 580–591. Gasperini, S., Crepaldi, L., Calzetti, F., ...
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<p>Leptin resistance: underlying mechanisms and diagnosis</p>
... Keywords: leptin, leptin resistance, soluble leptin receptor Introduction Leptin is an adipocyte-secreted hormone that regulates the appetite and represents a key factor in the ...
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ROLE OF LEPTIN IN OBESITY .......
... Inadequate receptor sensitivity results in dimin- ished responsiveness, which has two unfortunate results. First, normal fatty acid metabolism within the fat cells significantly declines and, the fat cells decrease their ...
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Biological Role of Leptin in Management of Obesity
... day’s obesity is a major health ...of obesity synthetic anti-obesity drugs posses more side ...of obesity. Leptin deficiency occurs in different conditions like lipodystrophy syndromes, ...
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Pathophysiological role of leptin in obesity related hypertension
... maturity-onset obesity and diabetes syndrome because of the antagonism of hypo- thalamic melanocortin system by the agouti protein (30, 31), thereby conferring resistance to the satiety effect of ...
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Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis
... of leptin in OA, the influence of BMI on chondrocyte response to the adipokine has not been ...elevated leptin levels in syn- ovial fluid and a high expression of leptin in cartilage compared with ...
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Leptin, adiponectin, and obesity among Caucasian and Asian women.
... adiposity. Leptin is a stronger predictor of CRP; however, in overweight and obese women, Asian women showed a stronger link between circulating CRP with both leptin and ...
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Obesity and insulin resistance
... between obesity and ...as leptin, cytokines such as TNF-α, and substrates such as FFAs allows the adipose organ to play a major regulatory role in energy balance and glucose ...
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Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population
... of leptin and adiponectin serum ...and leptin as dependent variables and on one hand the factors which p < ...central obesity index and negative impact on the ...
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