Leucine-rich repeat (LRR)
The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... the leucine-rich repeat (LRR) region of LRRK2, Shin and colleagues discovered that this portion of the protein interacts with Rab5b ...
170
Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... The leucine-rich repeats (LRR)-containing domain is evolutionarily conserved in many proteins associated with innate immunity in invertebrates and vertebrates, as well as ...60 ...
21
Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
235
The fibronectin leucine rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis
... known leucine-rich repeat cell-surface proteins failed to detect interactions between the Flrt paralogues and members of the Fgfr family (Sollner and Wright, ...extracellular LRR domains ...
12
Original Article Leucine-rich repeat neuronal protein 4 (LRRN4) potentially functions in dilated cardiomyopathy
... Several LRR proteins have been discovered functioned not only in response to pathological stimuli but also in various typical signaling pathways in DCM ...hypertrophy, LRR proteins are the focus of much ...
9
Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... Supplementary Materials: Table S1 : Female Aedes aegypti transcriptomic RNA-seq data show Leucine- Rich Repeat Proteins 7-days post infection or post injection between Key west and Orl[r] ...
12
The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression.
... The CCR4 Protein From Saccharomyces cerevisiae Contains a Leucine-Rich Repeat Region Which Is Required for Its Control of ADH2 Gene Expression.. Thomas Malvar,* Rachel W.[r] ...
12
Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease
... We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated ...
27
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
... In 2002 Funayama and collaborators reported a new genetic linkage to dominant inherited PD [51]. Two years later, independent groups not only described addi- tional families with linkage at the same chromosomal locus but ...
10
Point mutation in a leucine rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard Soulier syndrome
... expressed recombinant GP Ib alpha fragments to demonstrate that the observed mutation is the cause of defective von Willebrand factor binding. These studies define the molecular basis of the Bernard-Soulier syndrome ...
9
Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein
... In! ,I, I)c,', Bioi, ~O 5~5 555 (t996) 545 Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein REGINE ROUBIN*, SANDRINE PIZETTE, VINCENT[.] ...
11
The extracellular leucine rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
... predicted LRR motifs already (using the PFAM and SMART ...half repeat before the CT domain as one and did not include putative LRRs that overlapped with well-defined LRR-NT or LRR-CT domains ...
24
Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... small LRR-RK ectodomains. The LRR- RK ectodomain structures vary in shape and size, but the overall architecture is fairly ...27 LRR repeats ...repeating LRR units. Unlike BRI1 and PSKR1, none ...
158
Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins
... Fig. 1 Variable lymphocyte receptors as tools to target plant-expressed proteins. A schematic diagram depicting the steps involved in developing an LRR-containing VLR that binds to plant-expressed proteins. (1) ...
16
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry
... A case-control study was conducted in parallel, testing probands with ASD against unselected controls, using allele and genotype data from the same 66 SNPs genotyped across the four LRR genes. Minor allele ...
14
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
... 2 Wild-type (WT) mice displayed a significant reduction in home-cage activity by the fifth paraquat injection (10 mg/kg; ip), and this effect was reversed by LRRK2 knockout (KO) ( a ) bu[r] ...
13
Current knowledge and future directions of TLR and NOD signaling in sepsis
... LPS: Lipopolysaccharide; LRR: Leucine-rich repeat; LTA: Lipoteichoic acid; MAL: MyD88 adaptor-like; MAPK: Mitogen-activated protein kinase; MDP: Muramyl dipeptide; MyD88: Myeloid differe[r] ...
10
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
... Here, by assessing LRRK2-PKA RIIβ interaction and RIIβ phos- phorylation state, we found that LRRK2 G2019S interacts more with RIIβ compared to the WT protein in cells and brain lysates [r] ...
11
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
... Regardless of differences in experimental approaches, corresponding differences in p21 expression and cleaved PARP level have been com- monly observed in the differentiated SH-SY5Y cells[r] ...
15
Functional Characterisation of the Flax Rust AvrP/AvrP123 Avirulence Proteins
... into leucine-rich repeat (LRR) domain, lysin motif (LysM) domain, lectin domain, or epidermal growth factor (EGF)-like domain (Bohm et ...with LRR domains preferentially bind proteins ...
204