Leukemia inhibitory factor receptor
MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the hippo signaling pathway
... Cancer stem cells (CSC) are the main driving force behind cancer initiation and progression. The molecular mechanisms that regulate CSC properties are poorly understood. MicroRNAs (miRNAs) play a significant role in ...
13
Neuropathies of Stuve-Wiedemann Syndrome due to mutations in leukemia inhibitory factor receptor (LIFR) gene
... Stüve-Wiedemann syndrome (STWS; OMIM #610559) is a rare disease that results in dysfunction of the autonomic nervous system, which controls involuntary processes such as breathing rate and body temperature. In infants, ...
8
Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice
... because the processes are tightly coupled. Anabolic approaches now focus on uncoupling osteoblast action from osteoclast formation, for example, by inhibiting sclerostin, an inhibitor of bone formation that does not ...
12
Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules
... Leukemia inhibitory factor receptor (LIFR) is an integral component of glycoprotein130-LIFR complex and participates in signal transduction through interleukin-6 (IL-6) cytokine family ...
11
What does Stat3 do?
... and leukemia inhibitory factor receptor β (LIFRβ), leads to embryonic lethality (28), absence of LIF in female mice results in failure of embryo implan- tation (29), and cardiotrophin-1 ...
7
Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
... neurotrophic factor; DAMP: Damage-associated molecular patterns; DAVID: Database for Annotation, Visualization and Integrated Discovery; DM: Differentiation medium; EPO: Erythropoietin; EPOR: Erythropoietin ...
13
Leukemia inhibitory factor inhibits HIV 1 replication and is upregulated in placentae from nontransmitting women
... common receptor for a family of cytokines that also includes cil- iary neurotropic factor (CNTF), IL-11, oncostatin M, and, paradoxically, the HIV-1–inducing cytokine IL-6 ...
9
Leukemia inhibitory factor regulates microvessel density by modulating oxygen dependent VEGF expression in mice
... LIF is predominantly expressed in endothelial cells, and LIFR is expressed in surrounding cells during vascular development. Our first objective was to determine the expression pattern of LIF and LIFR in the mouse retina ...
12
gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine–neuro endocrine pathways
... larger receptor com- plex with a common subunit, the transmembrane glyco- protein gp130 ...functional receptor, triggers the association of IL-6Rα with gp130 (1, ...IL-6, leukemia inhibitory ...
6
Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility
... one receptor (PR) is the only factor as yet identified to be absolutely required for successful implantation, leukemia inhibitory factor (LIF) and mucin 1 are regarded as two of the ...
6
The effects of LIF and EGF on mouse oocyte maturation fertilization and development in vitro
... ligand, leukemia inhibitory factor (LIF), epidermal growth factor, bone morphogenetic proteins, keratinocyte growth factor, and basic fibroblast growth factor, that promote the ...
6
Inhibitory roles for SHP 1 and SOCS 3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
... We show SHP-1 to be associated with the LIF-stimu- lated JAK2-STAT3 complex. Whereas the association between SHP-1 and JAK2 is apparently independent of LIF stimulation, interaction between SHP-1 and STAT3 is LIF ...
10
Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
... Six-week-old male Swiss mice fed on chow were anes- thetized with a mixture of ketamine (100 mg/kg) and xylazine (10 mg/kg) perfused with saline and 4% parafor- maldehyde. The brain was totally removed and kept in a 4% ...
12
Pituitary directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function A model for human pituitary Rathke's cysts
... bolic development and function (1, 2). LIF arrests embryonic stem cell differentiation and selectively inhibits primitive ecto- derm formation in vitro (3). Disruption of LIF expression results in failure of uterine ...
9
Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome
... Embryonic implantation takes place on the uterine inner surface after a series of molecular and cellular interactions between the embryo and endometrium. Shedding of the zona pellucida, the apposition of the embryo to ...
9
Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling
... LIF receptor complex between the low-affinity LIF receptor (LIF-R) and a gp130 subunit ...and-mediated receptor assembly, the JAKs become activated and phosphorylate cytoplasmic proteins called ...
12
Human and murine pituitary expression of leukemia inhibitory factor Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion
... immunoelectron microscopy. Fetal LIF immunoreactivity colocalized with 30% of ACTH- expressing cells, approximately 20% of somatotrophs, and approximately 15% of non- hormone-expressing cells. LIF was also strongly ...
12
Activated Notch1 is a stronger astrocytic stimulus than leukemia inhibitory factor for rat neural stem cells
... In order to establish if our cortical cultures respond to LIF and CNTF stimulation, we performed immunodetection of Nestin, a filamentous protein characteristic of neural progeni- tors including NSC, together with GP130 ...
8
Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
... of leukemia inhibitory factor (LIF) and that higher LIF levels correlated with local tumor ...LIF receptor (sLIFR), a LIF antagonist, or the mTOR inhibitor rapamycin reversed LIF-mediated ...
16
<p>Cigarette smoke exposure reduces leukemia inhibitory factor levels during respiratory syncytial viral infection</p>
... c receptor LIFR, then recruits gp130 to form a high-af fi nity receptor com- plex to induce the activation of the downstream signal pathways, including JAK/STAT3, AKT, EKR1/2, and mTOR signal ...
11