Leukemic Stem Cell
Leukemic stem cell persistence in chronic myeloid leukemia patients in deep molecular response induced by tyrosine kinase inhibitors and the impact of therapy discontinuation
... CML cell growth could be another factor of ...residual leukemic stem cell ...CML stem cells were detected in patients who remained in deep molecular response after interferon-alpha ...
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Curcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression
... many cell types such as lymphocytes, osteoclasts, endothelial cells and tumoral ...and cell protection from cytotoxic and apoptotic ...cancer cell proliferation, invasion, metastasis, angiogenesis ...
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Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia
... Using cell-sorting, the authors showed that DNMT3A mu- tations were present in T-cells and B-cells at diagnosis in some patients, and also in T-cells several years after ...pre-leukemic stem ...
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Chronic Myelocytic Leukemia: ORIGIN OF SOME LYMPHOCYTES FROM LEUKEMIC STEM CELLS
... same stem cell origin as the leukemic myeloid ...the leukemic myelogenous cells displayed only one isoenzyme type, consistent with their clonal ...the leukemic stem cell, ...
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Bone marrow-derived mesenchymal stromal cell: what next?
... MSC is the main cell type present in clinical trials. However, placental, bone marrow, and fat-derived stromal cells have also been used, but the preference focuses on characteristics observed in animal studies; ...
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microRNAs: important regulators of stem cells
... Somatic cell reprogramming was discovered in 2006. iPSCs are successfully generated from mouse fibroblasts through virus-mediated transfection of Oct3/4, Sox2, Klf4, and c-Myc [2]. Human iPSCs are generated by ...
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Stem Cell Therapy: An Overview
... neural cell of eye – photoreceptor, interneuron and retinal ganglion cell or RGS- and essential supporting cell such as retinal pigment epithelium ...distinct cell types are conceivable target ...
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Arseni, Natalia (2006): Characterization of the Proteins HPIP and VENTX2 as Novel Regulatory Proteins of Human Hematopoiesis. Dissertation, LMU München: Medizinische Fakultät
... to FLT3 triggers the PI3K (phosphatidylinositol 3-kinase) and RAS pathways, leading to increased cell proliferation and the inhibition of apoptosis. PI3K activity is probably regulated through various interactions ...
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Hematopoietic stem cells and retroviral infection
... LSC/CSCs have the ability to self-renew, are seques- tered in the bone marrow microenvironment and are relatively resistant to conventional chemotherapeutic treatment regimens. The recent focus and characteriza- tion of ...
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Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?
... allogeneic cell source for the treatment of MI and ...other stem cells, expanded ex vivo to yield sufficient numbers and used in autologous or allogeneic fashion for transplantation (Figure ...pluripotent ...
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Patterns of Gelatinase-B Expression in Leukemic Cell Lines
... human leukemic Jurkat, Molt-4, and U937 cells could ex- hibit MMP-9 activity with different ...these cell lines, it seems that Molt-4 and U937 human leukemia cell lines, which greatly show MMP-9 ...
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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
... Transcriptomic analysis demonstrated that STAT3 expression can differentially regulate several important leukemic drivers that include IL1RAP, MSI2, CXCR2, IL8, and MCL1. We observed a strong correlation between ...
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MicroRNA 205 signaling regulates mammary stem cell fate and tumorigenesis
... ged1 signals from the stem/progenitor cell niche are critical for governing the cell fate decision (5, 6). A recent study also revealed that soluble jagged1, which is secreted from the tumor stroma, ...
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BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment
... for cell cycle, hypoxia, metabolism, and ...as cell-cycle, metabolic, hypoxia, oxida- tive phosphorylation, and Notch gene sets, and GEP of MSCs showed a significant reduction in surface adhesion and SDF-1 ...
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Sex Steroids and Stem Cell Function
... mesenchymal stem cells (MSCs) and endothelial progenitor ...progenitor cell migration from the bone marrow, yet the larger role of androgens in disease pathogenesis is not well ...neural stem cells ...
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Mesenchymal stem cell infusion for the treatment of neurological sequelae of canine distemper virus: a clinical study
... first cell therapy application, the animals began to present a slight decrease in the sequelae; after 30 days of therapy, there was noticeable improvement and the clinical evolution associated with the ...
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Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases.
... Stem cell factor (SCF), also known as steel factor or c-Kit ligand, has two protein forms, namely, membrane-bound stem cell factor and soluble stem cell factor, which mainly act ...
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LEUKEMIC CELL PROLIFERATION AS DETERMINED BY IN VITRO DEOXYRIBONUCLEIC ACID SYNTHESIS
... The intermitotic interval of acute leukemic cells could be many times longer than that of normal precursors and still retain a marked growth advantage because of: 1 the massive numbers o[r] ...
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Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium
... of stem cells at their base that give rise via proliferative progeny to the different differenti- ated intestinal cell types (Vermeulen and Snippert ...crypt, stem cells are replaced by a stochastic ...
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Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
... Inhibition of cell excitability via membrane hyperpolarization has traditionally been achieved using either light-gated inward chloride pumps (halorhodopsin, HR; Fig. 1) [35] or light-gated outward proton pumps ...
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