Leukemic transformation
FAETL motif required for leukemic transformation by v-Myb.
... and transformation activity ...for transformation, we further constructed a series of mutants with amino acid substitutions in the leucine repeat of v-Myb (Table ...caused leukemic ...
11
Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation
... (T-ALL) that is characterized by a high incidence of loss-of-function mutations in polycomb repressive complex 2 (PRC2) genes. We generated a mouse model of ETP-ALL by deleting Ezh2, one of the PRC2 genes, in p53-null ...
16
Frequency of L1721W Polymorphism in TET2 Gene Among a Cohort of Sudanese Patients with Myeloproliferative Disorders: Possible Roles in Pathogenicity and Leukemic Transformation
... Abstract: Transformation of myeloproliferative disorders (MPDs) to acute leukemia is an evitable event that represents a stumbling block in the management of ...this transformation within the study cohort ...
5
Leukemic transformation driven by an ASXL1 mutation after a JAK2V617F-positive primary myelofibrosis: clonal evolution and hierarchy revealed by next-generation sequencing
... the transformation of a JAK2V617F + -myelofibrosis with trisomy 8, into a JAK2V617F-negative ...leukemia. Leukemic clone did not carry JAK2V617F mutation, but showed ASXL1 mutation ...the leukemic ...
5
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
... induce leukemic transformation by a combination of aberrant gene methylation and consequent silencing of tumor suppressor genes, along with enhanced cell proliferation and/or resultant increase in ...
16
Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation
... without leukemic transformation, representing a pre-leukemia ...stepwise transformation, with no leukemogenecity evident upon initial injection into immunodeficient ...full transformation of ...
12
LEUKEMIC TRANSFORMATION IN LYMPHOSARCOMA OF CHILDHOOD
... Study cases are tabulated in Table I, show ing age, sex, histologic diagnosis, extent of disease at onset of therapy, initial therapy.. and response, days from completion of ini.[r] ...
13
MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 V617F positive primary myelofibrosis
... at leukemic trans- formation (Additional file 1 and Additional file 2: Tables S1, S2, ...at leukemic transformation, diagnosis and ...at leukemic transformation; targeted mutational ...
6
CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies
... of leukemic cell ...in leukemic stem cels was clearly higher that detectable on the same cell population isolated from normal bone marrow; interest- ingly, these CD123 + leukemic cells exhibited an ...
11
Ebinger, Sarah (2018): Characterization of dormant and drug resistant stem cells using xenograft mouse models of patient-derived acute leukemia cells. Dissertation, LMU München: Fakultät für Biologie
... time from injection to leukemia induced death of the mouse, and growth slowed down thereafter. Mathematically, the early growth of PDX cells in mice is logarithmic, but slows down if about 10 % of cells within the mouse ...
128
Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells
... corticosteroid administration. Anti-leukemic responses may potentially be mediated by donor lymphocytes for a limited period of time but, given the lack of durable chi- merism, we postulate that extended responses ...
7
LEUKEMIC INFILTRATION OF MENINGES AND SPINAL NERVE ROOTS
... LEUKEMIC INFILTRATION OF MENINGES AND SPINAL NERVE ROOTS. Services[r] ...
12
THE CEREBROSPINAL FLUID OF LEUKEMIC CHILDREN WITHOUT CENTRAL NERVOUS SYSTEM MANIFESTATIONS
... THE CEREBROSPINAL FLUID OF LEUKEMIC CHILDREN.. WITHOUT CENTRAL NERVOUS SYSTEM.[r] ...
6
Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML patients, the HPC from their remission bone marrow (remission-HPC), and normal HPC from their HLA-identical sibling bone marrow ...
8
Marrow Cell Egress THE CENTRAL INTERACTION OF BARRIER PORE SIZE AND CELL MATURATION
... The inability of leukemic blast cells to traverse small diameter pores suggests that the egress of leukemic cells may be dependent on a cell size smaller cells more likely to escape, b e[r] ...
12
Transfusion Support in Leukemic Children.
... Hemato-oncology services require many transfusions for a prolonged period. Profound anemia can alter hemostasis and thus should be avoided in patients with thrombocytopenia. 10 Kathryn E. Webert et al hypothesized that ...
65
Comparing the developmental pathways of leukemic
... VABS Adaptive functioning domain scores comparing: (a) children with leukaemia aged 229. 49-71 months one year post-treatment and matched controls; (b) VABS Adaptive functioning sub- 23[r] ...
18
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A Siwei Zhang 1, Lina S. Schneider1 , Binje Vick 2,4 , Michaela Grunert 2, Irmela Jeremias 2,3,4 , Dirk Menche 5, Rolf Müller6 , Angelika M. Vollmar 1and Johanna Liebl1
... human leukemic cells in flow cytometry upon staining of murine CD45 and human ...clear leukemic engraftment or by latest after 25 weeks, mice were sacrificed and human patient-derived xenograft (PDX) ...
21
TRENDS
... leukemic state in infants and children, University of Illinois College of Medicine,. Chicago[r] ...
5
Chickenpox in Leukemic Patients— Factors in Prognosis
... GERALD BODEY, EUGENE MCKELVEY and MYRON KARON Factors in Prognosis. −−[r] ...
5