Leukocyte recruitment
Human Cytomegalovirus Subverts the Functions of Monocytes, Impairing Chemokine-Mediated Migration and Leukocyte Recruitment
... kocyte recruitment. A similar lack of recruitment was observed when testing serial dilutions (from undiluted to 10 ⫺3 ) of these conditioned supernatants (data not shown), ruling out the pos- sibility that ...
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CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation
... This finding demonstrated that the expression of CXCR2 on CNS-residing cells, including endothelial cells, astrocytes, and microglia, is more important than its expression on circulating cells during CNS inflammation. ...
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Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain
... in leukocyte recruitment has been well documented [49, ...and leukocyte recruitment ...in leukocyte rolling and adhesion was observed in the brain ...facilitate leukocyte rolling ...
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Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo
... of primary monocytes or neutrophils as shown by morphology, differentiation markers, functional assays and even genome-wide gene expression analysis [20, 22–24, 31–33]. Still, even after withdrawal of estrogen, ...
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Important Role of P-Selectin for Leukocyte Recruitment, Hepatocellular Injury, and Apoptosis in Endotoxemic Mice
... of leukocyte recruitment, liver enzymes, and hepatocyte apoptosis and reduced sinusoidal ...reduced leukocyte rolling and firm adhesion by 65 and 71%, ...toxin-induced leukocyte responses or ...
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Leukocyte adhesion in angiogenic blood vessels Role of E selectin, P selectin, and beta2 integrin in lymphotoxin mediated leukocyte recruitment in tumor microvessels
... the recruitment of effector cells into the tumor ...of leukocyte adhesion in TMV and demonstrate that stimulation of the neovascu- lature with cytokines and chemoattractants can result in P- and ...
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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
... on leukocyte recruitment in our (endotoxemia) model, we used only the agonist HU308 in the CASP-induced sepsis ...on leukocyte adhesion in the CASP model; an increase in the dosage of HU308 to 10 ...
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Leukocyte recruitment in preterm and term infants
... order to find a designated site to transmigrate from vessel into inflamed tissue [20, 21]. Intravascular chemokine gra- dients guide leukocytes to sites of damage [22]. Transmi- gration depends on many different factors ...
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Blocking the α4 integrin–paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
... Antagonists to α4 integrin show promise for several autoimmune and inflammatory diseases but may exhibit mechanism-based toxicities. We tested the capacity of blockade of α4 integrin signaling to perturb functions ...
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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
... decrease leukocyte recruitment and adhesion following ischemia/reperfusion injury ...decreased leukocyte recruitment to the vessels of Rock1 +/– mice ...
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Perspectives series: cell adhesion in vascular biology Role of PSGL 1 binding to selectins in leukocyte recruitment
... initiate leukocyte aggregation (53). Leu- kocyte–leukocyte interactions lead to secondary tethering of leukocytes to an P- or E-selectin surface, a potential mecha- nism for amplifying leukocyte ...
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Defining the Chemokine Basis for Leukocyte Recruitment during Viral Encephalitis
... in leukocyte recruitment to the encephalitic ...CNS leukocyte recruitment and modulate host im- mune responses, which in excess may otherwise contribute to vi- rus-induced damage and ...
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Kinin B2receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice
... cyte recruitment in various tissues ...reduce leukocyte-endothelium interactions after diverse inflammatory conditions, including global cerebral ischemia [4], leukocyte infiltra- tion in murine ...
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Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice
... the leukocyte extravasation/activation through interaction with their receptor, the formyl-peptide receptor (FPR) ...leukocytes recruitment or rolling/adhesion to the post-capillary venules, but affects the ...
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Female Gender Attenuates Cytokine and Chemokine Expression and Leukocyte Recruitment in Experimental Rodent Abdominal Aortic Aneurysms
... enhanced leukocyte adhesion in the rat cerebral circulation and suggested this was a mechanism underlying increased neural damage in ovariectomized females as compared to intact ...
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The effect of cytomegalovirus infection on molecules affecting leukocyte recruitment and migration
... The similarity of the increase in LFA-3 levels following both ganciclovir and foscarnet treatment suggested that this molecule had further increased above normal infect[r] ...
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Activation of A1-Adenosine Receptors Promotes Leukocyte Recruitment to the Lung and Attenuates Acute Lung Injury in Mice Infected with Influenza A/WSN/33 (H1N1) Virus
... Similarly, our data indicate that activation of A1-AdoRs by adenosine is a potent stimulus for the recruitment of alveolar macrophages and neutrophils to the lungs of influenza A virus-i[r] ...
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Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis
... diminished leukocyte recruitment to peritoneal venules that was observed in the endotoxemia model of sepsis [16] and the mouse cremaster microcir- culation during IP ...greater leukocyte ...
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Human Cytomegalovirus Induces a Biphasic Inflammatory Response in Primary Endothelial Cells
... FIG 3 Effect of hCMV on EC leukocyte recruitment in a flow-based assay. (Ai) Phase-contrast images of uninfected EC and hCMV-EC at 1 and 7 dpi, before and after TNF- ␣ treatment, prior to the addition of ...
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Chemokines and their role in airway hyper-reactivity
... Airway wall thickening, airway smooth muscle hypertrophy and subepithelial fibrosis in AHR Histologic studies have reported a marked increase in the amount of smooth muscle in airways from asthmatic sub- jects; this ...
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