Leukotriene B4 (LTB4)
Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage
... of leukotriene B4 (LTB4), a chemotactically active lipoxygenase product of arachidonic acid, we investigated the contribution of LTB4 to the total neutrophil chemotactic activity produced by ...
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The Comparison of the Levels of Leukotriene B4, TGF β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast
... [11]-[14]. Leukotriene is synthesized mainly by leukocytes and different types of cells by means of trancelullar me- tabolism including neutrophils, platelets and vascular ...cells. Leukotriene has ...
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Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells
... Our results indicated that leukotriene B4 LTB4 could effectively stimulate PMN adhesion to endothelial cell surfaces, in contrast to the sulfidopeptide leukotrienes C4, D4, and E4, and t[r] ...
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Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4
... shock. Leukotriene B4 (LTB4) is the primary eicosanoid product of neutrophils and is felt to be a mediator of host defense and ...of LTB4 and the omega-oxidation metabolites of ...of ...
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Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis
... the leukotriene biosynthesis cascade. Leukotrienes consist of leukotriene B4 (LTB4) and the cysteinyl leukotrienes: namely, leukotriene C4 (LTC4), leukotriene D4 (LTD4) and ...
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Leukotriene B4 omega hydroxylase in human polymorphonuclear leukocytes Partial purification and identification as a cytochrome P 450
... to leukotriene B4 (LTB4), but also catabolize this mediator of inflammation rapidly and specifically by ...of LTB4, human PMN were disrupted by sonication and subjected to differential ...
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Neutrophil accumulation in the lung in alpha 1 antitrypsin deficiency Spontaneous release of leukotriene B4 by alveolar macrophages
... radioimmunoassay, and absorption with anti-LTB4 antibody revealed that the majority of the chemotactic activity was leukotriene B4 (LTB4), a mediator absent from normal macrophage supernates. ...
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Effects of leukotriene B4 in the human lung Recruitment of neutrophils into the alveolar spaces without a change in protein permeability
... Leukotriene B4 (LTB4) is a major product of human alveolar macrophages and has potent chemotactic activity for neutrophils (PMN) in ...of LTB4 in the normal human lung, we instilled ...
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Decreased leukotriene B4 synthesis in smokers' alveolar macrophages in vitro
... Recent studies have shown that alveolar macrophages (AM) are able to release leukotrienes (LTs). Since cigarette smoking inhibits the cyclooxygenase pathway of arachidonic acid metabolism in the AM, we evaluated the LT ...
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Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes
... indomethacin. LTB4-induced aggregation is not readily reduced by the above inhibitors of arachidonic acid ...sufficient LTB4 to account for the AGEPC response. In addition, the rate of LTB4 ...
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Murine glomerular leukotriene B4 synthesis Manipulation by (n 6) fatty acid deprivation and cellular origin
... (LT) B4 is an important pro-inflammatory ...synthesize LTB4 when provided with exogenous substrate in a dose-dependent fashion in the presence of ionophore ...for LTB4 formation, was required for ...
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Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
... Methods: Mouse 3T3-L1 preadipocytes were treated with lipoxygenase (LOX) inhibitors, BLT antagonist, and small interfering RNA (siRNA) for BLT1 and BLT2 to block the LTB 4 -BLT signaling[r] ...
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Leukotriene B4 amplifies NF κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
... B Myd88 mRNA and C MyD88 protein expression in WT and 5-LO–/– macrophages treated with Socs1 and control siRNA, as determined by real-time RT-PCR and immunoblotting, respectively; mRNA l[r] ...
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Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
... On the other hands, a low-affinity LTB 4 receptor, BLT2, which is ubiquitously expressed in human and mouse tissues (85) including cornea and conjunctiva (86), was not involved in las[r] ...
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Dual inhibition of complement factor 5 and leukotriene B4 synergistically suppresses murine pemphigoid disease
... Histopatho- logical analysis and comparison of skin biopsies from mice treated with varying doses of Coversin in a preventative treatment regimen and harvested on day 12 of the antibody[r] ...
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Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice
... infection, leukotriene B 4 (LTB 4 ) is produced within seconds to minutes via arachidonic acid metabolism by 5-lipoxygenase (5-LO) to LTA 4 , which is further metabolized by the LTA 4 hydrolase (LTA4H) to LTB 4 ...
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Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
... However, we discovered that 12-HHT is an endogenous ligand of BLT2 using unbiased ligand screening and, with others, revealed that the 12-HHT- BLT2 axis mediates various biological funct[r] ...
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Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients
... Abstract: The reproducibility of exhaled breath condensate (EBC) mediators is not well documented in chronic obstructive pulmonary disease (COPD). This study assessed within assay (WA), within (WD) and between day (BD) ...
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Inhibition of the Histamine and Leukotriene B4 Release From Rat Peritoneal Exudate Cells By Six Bangladeshi Plants
... Bangladesh has the largest mangrove forests in the world which has been a vast source of bioactive compounds. Mangrove plants have been used in traditional folk medicines and extracts from mangrove species are widely ...
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Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
... range; LTB4, leukotriene-B4; MCP-1, mono- cyte chemoattractant protein-1; MPO, myeloperoxidase; mRNA, messenger ribonucleic acid; TGF- β , transforming growth factor- β ; TNF- α , tumor necrosis ...
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