liver X receptor α
Excess Nitric Oxide Activates TRPV1-Ca2+-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α
... LXR α instability and the formation of an LXRα–calpain complex after SNAP treatment broaden the implication of calpain in- volvement in the protein stability of ...LXR α degradation in vitro, which suggests ...
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Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression
... fasting liver, it is possible that the absence of insulin and the presence of unsaturated FAs alter the composition of cofactors and lipid mediators, thereby decreasing the binding LXRα to the SREBP-1c promoter ...
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Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
... Figure 3 Effects of LicA on (A) the LXR α -stimulated expression of lipogenic genes and (B) TG accumulation in mouse primary hepatocytes. (A) T0901317-induced expression of SREBP-1c, SCD1, FAS, and GPAT was ...
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The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia
... Background: This study investigates the effect of genistein (Gen) on the lipid profiles and expression of low‑density lipoprotein receptor (LDLR), liver X receptor α (LXRα) and ATP‑bin[r] ...
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Liver X Receptor: A novel therapeutic target
... The liver X receptors α and β are orphan nuclear receptors that are key regulators in maintaining cholesterol ...the liver X receptors also functions in lipid and carbohydrate ...
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Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver
... 13–17], liver X receptor α (LXRα) [2, 18, 19], and sterol regulatory element-binding proteins 1c (SREBP-1c) [3, 8, 20–23] are key mediators in elon- gases and desaturases messenger RNA (mRNA) ...
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Liver X receptors α and β regulate renin expression in vivo
... The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is critically regulated at the transcriptional level. In the pres- ...
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The role of the liver X receptor in chronic obstructive pulmonary disease
... Additional file 10: The effect of GW3965 on the production of CXCL10 from poly I:C stimulated BEAS-2Bs. Immunocytochemical staining confirmed the presence of LXR α (A) and LXR β (B) in BEAS-2Bs. Omission of the ...
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Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue
... Liver X receptors (LXRs) are nuclear receptors that heterodimerize with retinoid X receptors (RXRs) and bind to LXR-responsive elements (LXREs) con- taining direct repeats (DRs) of the core sequence ...
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Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
... Whole-liver lysates were prepared in Triton-X 100 lysis buffer containing protease inhibitors and protein con- centrations were quantified using the Bradford method with bovine serum albumin (BSA) as the ...
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Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet
... and liver total cholesterol (TC) and serum LDL-C induced by feeding high-fat diets were significantly reduced by low-dose Se and Mg ...and liver TG levels, liver function indexes ALT and AST and the ...
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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
... toll-like receptor 4 (Tlr4), toll-like receptor 9 (Tlr9), and TNF-α (Tnfa), were at comparable levels in tempol- or antibi- otic-treated mice (Supplemental Figure ...mice. Liver histology ...
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Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2
... There are several limitations to the study. Analysis of gene expression was performed on spinal cord homoge- nates, representing multiple cell types. It is possible that analysis of isolated microglia/macrophage might ...
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The Liver X Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development
... The liver X-receptors (lxrs) are ligand-activated tran- scription factors belonging to the nuclear receptor super- family conserved throughout evolution ...
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Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis
... C19MC: The human chromosomal 19 miRNA cluster; ER α : Estrogen receptor α ; ESC: Embryonic stem cells; GO: Gene ontology; HCT15 and SKCO1: Colorectal cancer; HepG2: Liver cancer; HWP: Hu[r] ...
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Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK mediated RXRα phosphorylation
... leukemia/RA receptor α (PML/RARα) fusion protein (4, 5), which blocks cells at the promyelocytic stage of differentiation by inhibiting retinoid- induced transcription (6, ...
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Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat
... Total RNA from the liver of each Wistar rat was extracted with Accuzol Reagent according to the manufacturer stated protocol (Bioneer, Korea). After that, synthesis of cDNA was organized according to the ...
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A retinoid X receptor (RXR) selective retinoid reveals that RXR α is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator activated receptor ligands
... To determine whether these heterodimers could activate a PPAR-responsive promoter, we transiently transfected four breast cancer cell lines with a heterologous PPAR pro- moter vector and determined reporter gene activity ...
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Some New Classes of Generalized Apostol Euler and Apostol Genocchi Polynomials
... parameter α and for b, c ∈ R , the generalized Apostol-Bernoulli polynomials B m−1,α n x, b, c; λ, m ∈ N, λ ∈ C, are defined, in a suitable neighborhood of t 0, with |t log b| < 2π if λ 1 or with ...
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Differentiability of solutions of stationary Fokker–Planck–Kolmogorov equations with respect to a parameter
... Immediate examples are cases with uniformly elliptic diffusion matrices and polyno- mial or exponential bounds on the drift coefficients possessing a sufficient dissipativity. In these examples, rather technical ...
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