Low-Density Lipoprotein Receptor
Familial Hypercholesterolemia in an Azorean Family: A Novel Mutation in the Low Density Lipoprotein Receptor Gene
... the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin type 9 ...and low-density lipoprotein cholesterol (LDL-C) ...
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Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury
... surface receptor for cholesterol uptake and traffic, low-density lipoprotein receptor (LDLR) is susceptible to be attacked by detrimental ...
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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E
... intermediate density lipoprotein (IDL) is profoundly influenced by apo ...the low density lipoprotein receptor (LDLR) with a high affinity, thereby facilitating the LDLR-mediated ...
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Low-density lipoprotein receptor-related protein in metalloproteinase-mediated pathologies: recent insights
... Abstract: Low-density lipoprotein receptor-related protein (LRP)-1, LRP-1b, LRP-2, LRP-5, and LRP-6 mediate the endocytosis of metalloproteinases and inhibitors and/or promote the expression ...
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Low pH-Triggered Beta-Propeller Switch of the Low-Density Lipoprotein Receptor Assists Rhinovirus Infection
... the low-density lipoprotein receptor (LDLR) family: LDLR proper, very-LDLR (VLDLR) and LDLR-related protein ...the receptor of major group HRVs actively contributes to viral uncoating, ...
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Hepatitis C Virus Stimulates Low-Density Lipoprotein Receptor Expression To Facilitate Viral Propagation
... bloodstream. Low-density lipoprotein receptor (LDLR) is involved in uptake of cholesterol rich low-density lipoprotein (LDL) particles from the ...of lipoprotein ...
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Autoantibodies to low density lipoprotein receptor related protein 2 (LRP2) in systemic autoimmune diseases
... We previously reported that autoantibodies (autoAbs) to the main epitope on CD69 reacted to its homologous amino acid sequence in low-density-lipoprotein-receptor-related protein 2 (LPR2), a ...
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Antibodies against low density lipoprotein receptor–related protein 4 induce myasthenia gravis
... acetylcholine receptor (AChR) and a kinase critical for NMJ formation, MuSK; however, a proportion of MG patients are double-negative for anti-AChR and anti-MuSK ...against low-density ...
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Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse
... the low density lipoprotein receptor (LDLR) in these two ...was receptor independent. 91% of the receptor-dependent transport identified in these animals was located in the liver ...
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Roles of low-density lipoprotein receptor-related protein 1 in tumors
... Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple ...
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Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice
... circulating low-density lipoprotein (LDL) cholesterol levels, is elevated in periodontitis ...LDL receptor (LDLR) gene and protein expression, as well as liver X receptors (Lxrs), inducible ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... interact with APP and regulate its trafficking and process- ing. In this review, we have discussed several possible mechanisms by which APP trafficking and processing are regulated by LRP, LRP1B, SorLA/LR11 and ApoER2 ...
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Expression of alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein and scavenger receptor in human atherosclerotic lesions
... three receptor systems have been characterized that could be involved in the development of foam cells: alpha 2-macroglobulin receptor/LDL receptor-related protein (alpha 2 MR/LRP), scavenger ...
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Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts
... these lipoprotein- deprived cells were subsequently incubated with human low density lipoprotein (LDL), there was a 7-fold increase in the cellular content of esterified cholesterol and a ...
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Role of Low Density Lipoprotein Receptor as a Potential Suppressor of Growth and Survival of Colorectal Cancer Cells
... To get a better insight into the potential tumour suppressor role of LDLR in CRC and the underlying signaling pathways through which it exerts its anti-tumourigenic effect, we ectopically overexpressed LDLR in all three ...
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Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners
... LDL receptor gene, is five times more frequent in the Afrikaner population of South Africa than it is in the population of the United States and ...LDL receptor alleles from 12 Afrikaner individuals ...
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Massive xanthomatosis and atherosclerosis in cholesterol fed low density lipoprotein receptor negative mice
... LDL receptor gene (LDLR-/- mice) were fed a diet that contained ...intermediate density lipoproteins (IDL), and LDL cholesterol, and a decrease in HDL ...
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N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors
... significantly increased, indicating that ApoB on LDL was recognized by LDLr on HepG2 cells and facilitated the NP uptake. Consequently, the intracellular drug concentration increased. Two blank NPs (NSC-NPs and ...
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Role of the Low-Density Lipoprotein Receptor in Entry of Bovine Viral Diarrhea Virus
... in lipoprotein-deficient serum results in upregu- lation of LDL receptor expression ...LDL receptor expression was monitored by flow cytometry, using anti-LDL receptor MAb C7 ...LDL ...
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Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
... a lipoprotein-free form into the space of Disse, where it has been proposed to associate with incoming remnant lipopro- teins, facilitating their clearance by the LDLR or LRP (18), a process called ...
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