low metastatic potential
Effects of transforming growth factor β-1 infected human bone marrow mesenchymal stem cells on high- and low-metastatic potential hepatocellular carcinoma
... Background: This study investigates the effects of human bone marrow-derived mesenchymal stem cell (hMSC) on migration and proliferation ability of hepatocellular carcinoma (HCC) with high- and ...
11
Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review
... a low metastatic ...typical low-grade adenomyoepithelioma, which may be more appropriately named “adenomyoepithelioma with carci- noma” as defined in the 4 th edition of WHO Classification of Tumours ...
7
Histopathological and Immunohistochemical Characteristics of a Local Aggressive Canine Hemangiopericytoma (CHP) after Surgery
... Canine soft tissue sarcomas (STSs) are a heterogeneous group of tumors that comprise several neoplastic entities characterized by low metastatic potential (up to 17% of cases) and a low to ...
6
Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer
... lignant potential is more ...had low metastatic potential, whereas cells with a relatively low expression encom- passed both high and low metastatic ...
10
Expression of epithelial to mesenchymal transition related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
... EMT has been found to be crucial in cancer dissemin- ation, endowing cells with metastatic and cancer stem cell properties [7,8]. It is characterized by downregulation of epithelial markers (e.g. cytokeratin 8, ...
11
Case Report Micropthalmia Transcription Factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers
... nodule had no epidermal connection and sur- rounded by fibroconnective tissue. The tumor cells were small to moderate in size and pleo- morphic. The nuclei were large with prominent nucleoli and high nuclear/cytoplasm ...
7
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis
... Monocarboxylate transporters (MCTs) play a major role in up-regulation of glycolysis and adaptation to acidosis. However, the role of MCTs in gastric cancer (GC) is not fully understood. We investigated the ...
12
Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice
... protein-positive metastatic foci were analyzed by fluorescence microscopy, and the integrated absorbance was quantitated by Image- Pro Plus software as described previously ...monary metastatic nodules and ...
9
Decreased Expression of 15 hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
... PGE2 is related to carcinogenesis through immu- nosuppression, inhibition of apoptosis, increase of metastatic potential of epithelial cells and pro- motion of angiogenesis. 3-7 Overexpression of cyclo- ...
6
Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling
... liver metastatic tissues and to show significantly downregulated expression of miR-199b in metastatic ...the low miR-199b expression and distant metastasis were two ...
14
Metastatic Infection by Methicillin Sensitive Staphylococcus aureus and its Potential Association to an Unusual Humoral Immunodeficiency
... Within field of infection, we found more or less severe cases of otitis media, sinusitis, bronchitis, pneumonia, septic arthritis, upper/lower urinary tract infections, meningitis, herpes zoster, pyoderma, cellulitis, ...
6
Nutrient Deprivation Modulates the Metastatic Potential of Breast Cancer Cells
... Conclusions: Nutrient deprivation is an environmental stress factor that can influence the behavior of cancer cells. Current treatments implement nutrient deprivation as a potential cancer treatment. Under short ...
8
FOXC2 augments tumor propagation and metastasis in osteosarcoma
... The highly aggressive osteosarcoma cell line 143B has been shown to metastasize to the lungs after injection of cells into nude mice [27]. Metastatic seeding in vivo was assessed by injecting 143B scr, 143B sh1, ...
11
Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability
... The free energy change in the adhesive interaction between a rigid spherical particle and a cell is presented in Eq. 1. The mechanism of particle engulfment is provided in a coarse-grained manner (details of the ...
14
Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer
... In light of its role in cancer progression, CDCP1 tissue expression has been examined as a potential cancer biomarker with conflicting results. For instance, increased CDCP1 expression correlated with poor ...
16
Expression of MMP 9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study
... Although, the initial hypotheses were not confirmed, the results of our examination are in accord with studies that demonstrate protective effect of elevated expression of MMP-9 and other MMPs in multiple cancers. In ...
7
Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials
... The nonpolar phase of extracts from human mammary epithelial and breast cancer cells, was used to investigate the lipid profile. Representative lipid spectra of samples derived from a pooled extract and MS/MS spectra of ...
18
ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone
... The University of Pittsburgh Medical Center (UPMC) Musculoskeletal Oncology Research Registry and Tissue Bank is an Institutional Review Board-approved data collection system wherein signed written informed consent from ...
8
Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype
... highly metastatic human cell lines in vitro and in vivo, which suggested that it may be a metastasis inhibi- ...tor. Metastatic human melanoma cells were transfected with SEMA3F and implanted into mice; the ...
13
Inhibition of Filamin-A Reduces Cancer Metastatic Potential
... that low levels of filamin-A ex- pression in cancer cells of the tumor tissues are associated with a better distant metasta- sis-free survival than those with normal levels of ...
11