LRR, leucine rich repeat
Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... small LRR-RK ectodomains. The LRR- RK ectodomain structures vary in shape and size, but the overall architecture is fairly ...27 LRR repeats ...repeating LRR units. Unlike BRI1 and PSKR1, none ...
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Current knowledge and future directions of TLR and NOD signaling in sepsis
... LPS: Lipopolysaccharide; LRR: Leucine-rich repeat; LTA: Lipoteichoic acid; MAL: MyD88 adaptor-like; MAPK: Mitogen-activated protein kinase; MDP: Muramyl dipeptide; MyD88: Myeloid differe[r] ...
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Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... The leucine-rich repeats (LRR)-containing domain is evolutionarily conserved in many proteins associated with innate immunity in invertebrates and vertebrates, as well as ...60 ...
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The extracellular leucine rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
... define LRR-NT and several varieties of LRR-CT domains found in different types of proteins, including small proteoglycans and G-protein-coupled receptors ...half repeat is counted as one and whether ...
24
The fibronectin leucine rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis
... 10 leucine- rich repeats flanked by cysteine-rich regions, a type III fibronectin domain followed by the transmembrane segment and a short intracellular tail (Lacy et ...other LRR cell-surface ...
12
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry
... A case-control study was conducted in parallel, testing probands with ASD against unselected controls, using allele and genotype data from the same 66 SNPs genotyped across the four LRR genes. Minor allele ...
14
Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins
... their LRR domains ...N-terminal LRR (LRRNT), multiple LRRs with variable sequence (up to 10 have been observed in a mature VLR [21]; the first LRR and the last one are referred as LRR1 and LRRVe, ...
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Original Article Leucine-rich repeat neuronal protein 4 (LRRN4) potentially functions in dilated cardiomyopathy
... Several LRR proteins have been discovered functioned not only in response to pathological stimuli but also in various typical signaling pathways in DCM ...hypertrophy, LRR proteins are the focus of much ...
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The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... the leucine-rich repeat (LRR) region of LRRK2, Shin and colleagues discovered that this portion of the protein interacts with Rab5b ...
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Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
235
Functional Characterisation of the Flax Rust AvrP/AvrP123 Avirulence Proteins
... into leucine-rich repeat (LRR) domain, lysin motif (LysM) domain, lectin domain, or epidermal growth factor (EGF)-like domain (Bohm et ...with LRR domains preferentially bind proteins ...
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Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S Parkinson’s disease
... Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. While most of PD cases are idiopathic, monogenic forms of the disease are demon- strated in about 5–10% of patients [1]. Mutations in leu- ...
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Molecular mechanisms used by Staphylococcus aureus to access iron from human haemoglobin
... anthracis isothermal titration calorimetry equilibrium dissociation constant Luria-Bertani broth Milli-Q® water leucine rich repeat myoglobin mass spectrometry weight average molecular w[r] ...
265
Toll-like receptors activation, signaling, and targeting: an overview
... Lipopolysaccharides; LRR: Leucine-rich repeats; LTA: Lipoteichoic acid; miRNAs: MicroRNA inhibitors; mtDNA: Mitochondrial DNA; MyD88: Myeloid differentiation primary- response protein 88; MAPK: ...
12
Genetic analysis of odor-guided behavior in Drosophila melanogaster
... Epithelial and neuronal cells share a common structural and functional property in that they are both polarized. Neurons, for example, have topologically distinct pre- (axonal) and post-synaptic (dendritic) domains that ...
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Investigating the Multiple Hit hypothesis of Parkinson disease using transgenic LRRK2-R1441G rats
... Parkinson disease, leucine-rich repeat kinase 2, genetic model, transgenic BAC rats,.. motor test, cognitive assessment, ‘multiple hit’ hypothesis, Paraquat..[r] ...
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Point mutation in a leucine rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard Soulier syndrome
... Leucine-rich repeats are a conserved structural motif, of yet undefined significance, found in a group of proteins from different species. Among these are the four components of the human platelet ...
9
Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein
... In! ,I, I)c,', Bioi, ~O 5~5 555 (t996) 545 Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein REGINE ROUBIN*, SANDRINE PIZETTE, VINCENT[.] ...
11
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
... 2 Wild-type (WT) mice displayed a significant reduction in home-cage activity by the fifth paraquat injection (10 mg/kg; ip), and this effect was reversed by LRRK2 knockout (KO) ( a ) bu[r] ...
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Computational and experimental analysis of plant promoters : identifying functional elements
... Successful predictions of functional binding site motifs is an open problem in the field of biology. No high-throughput and cost-effective screen has been devised to test for all possible binding sequences that protein ...
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