Lung cancer stem cells
Gefitinib loaded DSPE PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells
... Lung cancer is a leading cause of cancer death and pre- dicted to be the leading cause of cancer death in 2017 in the USA ...2015, lung cancer was the leading cause of ...
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LUNG CANCER STEM CELLS-AN UPDATE
... tumor cells overexpressing ALDH1A1 have significant resistance to EGFR tyrosine kinase inhibitors and chemotherapy drugs 63 likely resulting in their poor clinical outcome ...for lung cancer ...
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Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells
... mammalian cells by different ubiquitin-dependent mechanisms, among them the Itch- dependent degradation of p73 is the most characterized ...on lung CSCs survival depends of its activity as inhibitor of ...
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Wnt blockers inhibit the proliferation of lung cancer stem cells
... PC9 cells, but not A549 ...pluripotent stem cell markers, including NANOG, Oct4, KLF5, and SOX2, and Wnt signaling pathway molecules β-catenin and ...pluripotent stem cell signaling pathway were ...
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Original Article Development and anti-tumor effects of lung cancer stem cell chaperon molecule antigen peptide vaccine
... for lung cancer vaccine mainly focuses on the preparation of auto-anti- body from primary tumors or tumor cells col- lected from surgery or xenograft antigen vac- cine originated from isotopic tumor ...
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Stem cells: a model for screening, discovery and development of drugs
... mesenchymal stem cells offer an attractive high throughput screening platform for new target/ drug ...These stem cells can be readily expanded in vitro and can be isolated from a variety of ...
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To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
... the lung and subcutaneous locations of tumors may have different microenvironmental influences on tumor and MSC fate ...the cancer stem cell (CSC) niche (Figure ...breast cancer CSC population ...
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Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
... ovary cancer cells, stem-like CD24- cells or spher- oids highly expressed cyclin D1, Bmi-1, and vimentin with reduced expression of E-cadherin, while non stem-like CD24+ or parental ...
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Cancer stem cell subsets and their relationships
... tumor cells tend to move to their specific distant organs, and differ- ent distant organs tend to accept specific tumor cells ...transplanted lung, ovarian and kidney tissues into subcutaneous and ...
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<p>Differential Expression And Effects Of Peroxiredoxin-6 On Drug Resistance And Cancer Stem Cell-Like Properties In Non-Small Cell Lung Cancer</p>
... A total protein isolation kit (Solarbio, Beijing, China) was used to extract the total proteins from tissues and cells. The protein concentration of each sample was estimated with a BCA protein assay kit (P0012, ...
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Original Article Enhanced expression of stem cell markers and drug resistance in sphere-forming non-small cell lung cancer cells
... that cancer stem cells (CSCs) are playing critical roles in tumor pro- gression, metastasis and drug ...cell lung cancer (NSCLC) remains ...for stem-like cells from tumor ...
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Original Article Association of AXIN2 and MMP7 polymorphisms with non-small cell lung cancer in Chinese Han population
... the cancer stem cells (CSCs) in lung cancer, the results show that Wnt signal pathway plays an vital role in maintaining highly resistant CSCs and regulating cell cycle, apoptosis and ...
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Stem cells and repair of lung injuries
... Major lung diseases likely involving stem cells and the cel- lular targets for stem cell therapy are summarized in Table ...involve stem cell deficiency, hyper-proliferation or ...
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The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo
... pancreatic cancer cell line PANC-1 was obtained from the Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku ...ovarian cancer cell line A2780 was a kind ...
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Influence of the Metastatic Microenvironment on Stem-like Human Breast Cancer Cells
... disseminated cancer cells, interactions between these cells and the microenvironment will likely promote colonization and secondary tumour formation 106 ...of cancer cells reaching the ...
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Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
... We next investigated whether TAZ and/or YAP im- pacted DFS. At a median follow-up of 31 months, 19 events were recorded in the 57 evaluable patients. As previously specified in the “Study Participants and pro- cedures” ...
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Potential role of stem cells in management of COPD
... Mesenchymal stem cells (MSCs) are nonhematopoietic stem cells of mesodermal origin, with the capacity to differentiate into both mesenchymal and nonmesenchymal ...
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Role of stem cells in cancer therapy and cancer stem cells: a review
... of stem cells as delivery vehicles came from the fact that the tumours, similar to the wounds, send out chemo-attractants such as the vascular endothelial growth factor (VEGF) to recruit MSC to form the ...
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Isolate and identified cancer stem cells by using MCF7 human breast cancer cell line, using mammospheres formation in two different methods
... of cancer. In order to study cancer stem cells in details, it is required to identify the biomarkers of CSCs that form an essential target for ...for cancer stem ...breast ...
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<p>Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages</p>
... cant cancer treatment method for many years in ...in cancer patients compared to M1-polarized tumor- associated macrophages ...in cancer are ...
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