Lupus anticoagulant
Overt increase in lupus anticoagulant level in HIV patients co-infected with pulmonary Mycobacterium tuberculosis infection: A prospective cohort study
... 21]. Lupus anticoagulant is now considered to be a significant risk factor in patients with otherwise unexplained thrombotic events including women who have recurrent fetal loss ...with anticoagulant ...
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Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2 glycoprotein I
... similar anticoagulant properties, the relationship of beta 2GPI to lupus anticoagulant activity was ...and lupus anticoagulant activity in the presence and absence of beta ...no ...
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In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
... Despite an increasing interest in membrane-shed MPs, little is known about MPs of endothelial origin. In vitro experiments have established that complement proteins C5b-9 induce vesiculation of the endothelial plasma ...
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Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
... Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII ...
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Anti beta2 glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant like activity enhance the beta2GPI binding to phospholipids
... exhibits anticoagulant properties in vitro, such as the inhibition of the intrinsic blood coagulation pathway (11, 12), and the prothrombinase activity of activated platelets ...of lupus ...
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Localization of the apoptosis inducing activity of lupus anticoagulant in an annexin V binding antibody subset
... Lupus anticoagulant (LAC) is associated with arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss. We have reported previously that plasma with LAC ac- tivity induces apoptosis in ...
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Original Article Incidence of anticardiolipin antibodies and lupus anticoagulant factor among women experiencing unexplained recurrent abortion and intrauterine fetal death
... than lupus anticoagulant in both studied group. Lupus anticoagulant was positive in 30% of abortion and ...and lupus anticoagulant. It was found that ACA were twice of ...
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Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant
... Ninety-eight patients (65.3%) had a history of thrombotic events (TEs) before study inclusion (arterial: n =21, ven- ous: n = 84, both: n = 7). Patients with a history of TE were significantly younger than patients ...
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Thrombin generation as marker to estimate thrombosis risk in patients with abnormal test results in lupus anticoagulant routine diagnostics
... Samples from 63 patients were retrospectively selected from the LA testing program of the laboratory from January to December 2009 (Figure 1). Indications for la- boratory investigation were previous thrombosis, evalu- ...
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Monoclonal immunoglobulin M lambda coagulation inhibitor with phospholipid specificity Mechanism of a lupus anticoagulant
... Substitution of washed platelets for phospholipid led to normalization of patient coagulation tests and corrected all abnormalities produced in normal plasma by patient IgM.. Furthermore[r] ...
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Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor
... The effect of using three different sourcesof tissue factor recombinant,human brain and rabbit brain thromboplastinsin the TFPI assay was examined.. Of most significance was the apparent[r] ...
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Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant
... anticoagulant). HLA-DQw7 (DQB1*0301), linked to HLA-DR5 and -DR4 haplotypes, occurred in 70% and was significantly increased compared to 139 race-matched normal controls (P = 0.002, P corrected [pc] = 0.05, odds ...
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Profile of patients with Thrombosis evaluated in a Tertiary Care Center.
... Therefore an abnormality often exists in phospholipid dependant coagulation reactions, including prothrombin time, activated partial thromboplastin time and Russell’s viper venom test, because the LA is not directed ...
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LA and aCL in an unselected popula- tion of children with idiopathic cerebral ischemia and to compare the clinical and radiological features observed in aPL-positive and aPL-negative patients. PATIENTS AND METHODS
... To investigate the prevalence of aPLs, de- tected as lupus anticoagulant (LA) or anticardiolipin an- tibody (aCL), in a group of unselected children with idiopathic cerebral ischemia.. D[r] ...
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Anticardiolipin antibodies in unexplained pregnancy loss
... Antiphospholipid Syndrome may be either primary if other features of connective tissue disease are absent or secondary to established connective tissue diseases such as systematic lupus erythematosus. It is ...
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Role of Antiphospholipid Antibody in Early Pregnancy Loss
... Accepted: 22 Apr 2015 Aim & objective- To detect correlation between antiphospholipid antibodies in early pregnancy losses. Material & Method- In this study 70 patients were taken from the department of ...
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Acquired activated protein C resistance and thrombosis in multiple myeloma patients
... lant was important in this case. Patients with APCR were negative for lupus anticoagulant. We found only one patient with genetic PCR who did not develop thrombo- sis. People with the APC-R phenotype ...
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Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay
... include lupus anticoagulant, a functional coagulation assay, and anticardiolipin and anti-β2-glycoprotein-I antibodies, generally detected by solid phase enzyme-linked immunosorbent ...assay, Lupus ...
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Assessment of Antiphospholipid Antibodies, CD4 Count and Some Haematological Parameters in HIV Patients attending a Tertiary Health Institution in South-Western Nigeria
... HIV is a pandemic and has remained a public health concern for many decades. HIV infection, though associated with many opportunistic infections and neoplasms, it is further complicated with marked depletion of the CD4 ...
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On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies
... minimal lupus anticoagulant activity are identified whose plasma potently inhibits activated protein C anticoagulant ...C anticoagulant activity and the PE dependence of some antiphospholipid ...
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