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Lymphoblastic T-cell leukemia

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

... [12–15]. T- ALL patients are more likely to have a worse steroid re- sponse than B-ALL patients [8, 10, ...established leukemia groups [19 – ...of T-cell receptor (TCR) and clone-specific ...

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Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia

Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia

... The authors would like to thank the donors for agreeing to have their cells used for research, and the clinical teams from Hôpital A Trousseau and Hôpital R Debré in Paris, for their dedicated aid in collecting samples. ...

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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia

T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia

... mature T-ALLs (8/14) that usually displayed T3. The 3A-1 T cell associated antigen appeared earliest in development followed by T11 and ...pre-B cell ALL a higher incidence of lineage ...

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SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines

SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines

... human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the SET(TAF-Iβ)-NUP214 fusion gene ...the cell lines also ...

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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

... of T-ALL cells to overcome the cytotoxic effects of chemotherapy is a critical step in developing more effective ...on cell viability, we screened nearly 500 thera- peutic compounds and identified 22 ...

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Induction of human B cell antigens in non T cell acute lymphoblastic leukemia

Induction of human B cell antigens in non T cell acute lymphoblastic leukemia

... non-T cell ALL lines ...promyelocytic leukemia line or a T cell lymphoblastic leukemia ...non-T cell ALL lines, cytoplasmic mu-heavy chain (c mu) became ...

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T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with NOTCH1 mutation as a good prognostic factor

<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>

... and T/M-MPAL share cell antigens which characterize T- and myeloid phenotypes, we wanted to test if molecular aberrations frequently found in T-ALL and AML would help in the distinction of ...

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Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia

Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia

... et al characterized the cellular accumulation of ara-GTP and the related clinical response elicited in patients diagnosed with various hematologic malignancies including T-ALL, CML-BC (chronic myeloid ...

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Different stages of B cell differentiation in non T acute lymphoblastic leukemia

Different stages of B cell differentiation in non T acute lymphoblastic leukemia

... acute lymphoblastic leukemia (ALL) and correlated with the immunological phenotypic expression on primary or phorbol diester (12-O-tetradecanoylphorbol-13-acetate [TPA])-induced ...of T-ALL, and one ...

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Potential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia

Potential for bispecific T-cell engagers: role of blinatumomab in acute lymphoblastic leukemia

... Safety profile appears as favorable, but life-threatening reactions can result from massive release of cytokines. Blinatumomab can also cause B-cell depletion, leading to a decrease in Ig levels and therefore an ...

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MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia

... pediatric T-cell acute lymphoblastic leukemias ...pediatric T-ALL, MYCN-expressing samples were found almost exclusively in the TAL1-positive ...in T-ALL cell lines resulted in a ...

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Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia

Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia

... from T-ALL patients ...eight T-ALL patients are presented (Table 1), consisting of one with refractory disease (ALL-31), one with chemo-resistant disease who died early (ALL-44), three with early relapse ( ...

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Phenothiazines induce PP2A mediated apoptosis in T cell acute lymphoblastic leukemia

Phenothiazines induce PP2A mediated apoptosis in T cell acute lymphoblastic leukemia

... suppressed T-ALL cell growth in the presence of GSI (the +GSI composite Z score) and the extent to which this suppression exceeded that observed in the absence of GSI (the so-called 2-assay score; Figure ...

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Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia

... Spontaneous tumor lysis syndrome (STLS) is an oncologic emergency characterized by severe electrolyte disturbances, metabolic acidosis, and acute renal failure (ARF) before the initiation of chemotherapy. It is most ...

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Targeting IRAK1 in T-Cell acute lymphoblastic leukemia

Targeting IRAK1 in T-Cell acute lymphoblastic leukemia

... acute lymphoblastic leukemia (T-ALL) represents expansion of cells arrested at specific stages of thymic development with the underlying genetic abnormality often determining the stage of maturation ...

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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors

Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors

... acute leukemia (t-AL) is an observed carcinogenesis due to the toxic side effects of ion- izing radiation and/or conventional chemotherapy for primary ...myeloid leukemia (t-AML) accounts for ...

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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines

P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines

... with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor ...of T-ALL relapse patient ...B cell line (HABL) was established. ...

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The molecular basis of T cell acute lymphoblastic leukemia

The molecular basis of T cell acute lymphoblastic leukemia

... of T-ALL ...of T-ALL in transgenic mice expressing TAL1 in developing thymocytes (62, ...In T-ALL cells, TAL1 forms pri- marily inactive transcriptional complexes that contain E proteins and the LMO ...

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Subset derivation of T cell acute lymphoblastic leukemia in man

Subset derivation of T cell acute lymphoblastic leukemia in man

... blood T cells can be characterized as belonging to either the TH+2 or TH-2 T-cell ...of T cells are TH+2, whereas 80% are TH- 2 utilizing specific ...human T-cell acute ...

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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas

Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas

... human T cell acute lymphoblastic leukemia (T-ALL) [1–3] and several murine T-ALL models, including ATM − / − thymic lymphomas [4 – ...murine T-ALLs retain at least one ...

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