M2-like macrophages
Ixmyelocel-T, an expanded multicellular therapy, contains a unique population of M2-like macrophages
... of M2 macrophages, including ingestion of apoptotic cells, exposure to the Th2 cytokines IL-4 and IL-13, exposure to IL-10, and contact with mesenchymal stem cells ...unique M2-like ...produce ...
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Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1
... derived macrophages; CFSE: Carboxyfluorescein succinimidyl ester; CLL: Chronic lymphocytic leukemia; CPRG: Chlorophenol red- β -D-galactopyranoside; CTLs: Cytotoxic T lymphocytes; DAMPs: Damage-associated ...
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TLR2 stimulation impairs anti inflammatory activity of M2 like macrophages, generating a chimeric M1/M2 phenotype
... or M2 or an as yet undefined macrophage population predominates numerically and functionally in RA [19, 26, ...and M2 polarization displays a high grade of plasticity [28], and the phenotype and activation ...
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Dysregulated heme oxygenase 1low M2 like macrophages augment lupus nephritis via Bach1 induced by type I interferons
... + M2-like cells was greater than that of pSTAT1 + M1-like cells in the glomerulus of LN ...Mϕ, M2-like Mϕ, and HO-1 per glom- erulus of patients with LN were ...+ M2- like ...
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Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects
... M1 macrophages, which activate antitumor ...suppressive M2-like phenotype, which could support multiple aspects of tumor ...how macrophages in tumor-associated stroma could be hijacked to ...
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Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb
... an M2-like phenotype. Com- pared with M1 macrophages, our data show that M2- like macrophages polarized by exosomes from ASCs se- crete more angiogenic factors and that CdM from ...
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Original Article Expression of stabilin-1 in M2 macrophages in human granulomatous disease and melanocytic lesions
... M1-like macrophages, which are held against anti-inflammatory or M2-like ...M1 macrophages are induced by IFN-γ or TNF-α, while M2 macrophages result from stim- ulation ...
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Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages
... inhibits M2-like macrophages promoted angiogenesis in ...in macrophages treated with IL- 13(10 ng/ml), metformin(1 mM), or both of them for 24 ...
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ
... to macrophages PBMC were separated from buffy coats of healthy adult donors (Sanquin Blood bank, Region Southwest, Rotter- dam, the Netherlands) by Ficoll-Hypaque density gradient ...and M2-like ...
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Roles of M1 and M2 Macrophages in Herpes Simplex Virus 1 Infectivity
... and M2 macrophages play in control of HSV-1 ...M1 macrophages derived from both the ...to M2 macrophages or unpolarized ...M1 macrophages derived from the murine ...unpolarized ...
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Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration
... PDLSCs promoted periodontal regeneration in vivo Allogeneic PDLSCs carried by membrane materials were transplanted into the periodontal defect in rats (as illus- trated in Fig. 2a, c). The reconstructed images of ...
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The macrophages in rheumatic diseases
... as macrophages. In vitro, human monocyte-derived macrophages were, as predicted, less efficient at removing ANCA-treated apoptotic neutrophils than untreated apoptotic ...
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Clinical significance of macrophage phenotypes in cardiovascular disease
... distinct macrophages are found in regions of plaque haemorrhage displaying a non foam cell form ...Mhem macrophages shows that they are resistant to foam cell formation through down regulation of scavenger ...
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Role of innate and adaptive immunity in obesity associated metabolic disease
... above, macrophages were shown to populate subcutaneous AT (SAT) and visceral AT (VAT) in mice, correlating with total adiposity as well as with adi- pose cell size ...AT macrophages (ATMs) and adipose cells ...
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Original Article Influence of type 2 macrophages (M2) in echinococcosis
... disease. M2 had a weak ability of presenting, which reduced the specificity immune ...Il-10, M2 could inhibit th1 immune response, and repaired injured tissue, grew blood vessel, decreased inflammation ...
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MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway
... Total proteins from macrophages were extracted using RIPA lysis buffer. The protein concentration of the cell lysates was determined with a BCA protein assay (Beyo- time, China). Samples containing equal amounts ...
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Original Article Status of M1 and M2 type macrophages in keloid
... M1 macrophages (CD68 positive immunostaining) and M2 macrophages (CD163 positive immu- nostaining) were counted in one random high power field (200× magnification) five ...
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Original Article Overexpression of IL-12 reverses the phenotype and function of M2 macrophages to M1 macrophages
... Interleukin-12 (IL-12), linking the innate and adaptive immune responses, belongs to the IL-12 family of cytokines. Consisting of the subunit p35 (a light chain) and p40 (a heavy chain) [9], IL-12 is mainly produced by ...
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Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages
... of M2-TAMs to M1 macrophages that subsequently recruited and activated CD8 + T cell; and (IV) we used the orthotopic mouse model, which mimics the clinical drug delivery method, to evaluate whether this ...
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Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment
... kill macrophages (Figure ...1C). Like the first experiment, there was no statistically significant difference between the combined- treatment group and IFN γ -alone or celecoxib alone groups ...
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