Macrophage foam cells
Cyclodextrins as catalysts for the removal of cholesterol from macrophage foam cells
... A variety of HDL subclasses have been implicated in cellu- lar cholesterol efflux. Small, phospholipid-rich particles, char- acterized as pre b -HDL, have been proposed as the initial ac- ceptors of cholesterol (5), ...
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Chlamydia pneumoniae Accelerates Coronary Artery Disease Progression in Transgenic Hyperlipidemia-Genetic Hypertension Rat Model
... on macrophage foam cell formation, coronary artery disease progression, and effect on ...of foam cell formation in hyperlipi- demic Tg53 recruited peritoneal ...Tg53-Cpn macrophage foam ...
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<p>Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages</p>
... Isoborneol, an isomer of borneol, is a monoterpenoid alcohol present in the essential oils of numerous plants. 10 Many Chinese medicines used for the treatment of cardiovas- cular disease contain borneol or isoborneol. ...
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Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
... Both macrophage-mediated cholesterol metabolism and pro-inflammatory cytokine secretion are central steps in the initiation and progression of atherosclerosis [13, ...of macrophage foam cells ...
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Loss of receptor mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
... generated macrophage foam cells via pathways that remain undefined or do not have characteristics consistent with scavenger receptor ...which foam cells could form in vivo (13, 22, ...
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Reactive oxygen species produced by macrophage derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro Implications for atherosclerotic plaque stability
... by macrophage-derived foam cells could trig- ger activation of latent proforms of metalloproteinases in the vascular ...generated macrophage foam cells produce superoxide, nitric ...
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Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
... of macrophage foam cells (MFCs) essential con- stituents of human atherosclerotic lesions ...lesion foam cells and lead to regression of the atherosclerotic process ...
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Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress
... of foam cell ...The cells in atherosclerotic plaques develop progressive lysosomal dysfunction with features resembling a lysosomal storage disease ...in macrophage foam cells ...
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<p>Effects of Two Types of Moderate- and High-Intensity Interval Training on Serum Salusin-α and Salusin-β Levels and Lipid Profile in Women with Overweight/Obesity</p>
... and macrophage in fi ltra- tion after 4 and 8 weeks injections Salusin β , but no changes was obtained in total ...of macrophage foam cells, and there were also positive changes in lipid pro fi ...
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Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI containing lipoproteins, so reducing the cholesterol efflux inducing ability of serum and aortic intimal fluid
... proteolyzing human serum and human aortic intimal fluid, prevents these two physiologic fluids from effectively inducing cholesterol efflux from cultured macrophage foam cells. Inhibition was ...
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Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
... An important concept to arise from these cell-culture studies is the importance of intracellular cholesterol trafficking in FC-induced death. Rothblat and col- leagues (20) were the first to show that amphipathic amines, ...
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Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
... muscle cells are the major sources of LPL synthesis; LPL is then secreted and transported to the luminal surface of the vas- cular endothelium, where it is bound to heparan sulfate proteoglycans ...by ...
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Anti-atherosclerotic activity of n-Hexane extract of Eleutherine americana Merr. on human macrophage primary cell culture
... The cells were then washed three ...minutes. Cells were then incubated in primary antibody which was diluted in 1% BSA in PBST overnight at 4°C ...and cells were washed with PBS three times for 5 ...
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Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte generated reactive nitrogen species
... reactive oxidants and diffusible radical species (17–22). Immunohistochemical and mass spectrometric studies demonstrate that MPO and multiple distinct oxidation products formed by MPO are enriched in human atheroma ...
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Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice
... of a high-fat diet, Ad-C5a injection produced more extensive lesions than control adenovirus, and its proathrosclerotic role was significantly blocked by C5a receptor antagonist. Immunohistochemical analysis showed ...
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You are right too!
... Macrophage scavenger receptors, such as CD36 and class A scavenger receptor (SR-A), have previously been thought to play a central role in foam cell formation and atherogenesis by mediating the uptake of ...
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Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
... in macrophage-derived foam cells by inhibiting the lipogenic enzyme, stearoyl CoA desaturase1 (SCD1) through activation of a nuclear receptor farnesoid-X-receptor (FXR) pathway ...
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Differentiation of C2D Macrophage Cells after Adoptive Transfer
... C2D macrophage phenotype. The adoptive transfer of C2D macrophage cells allows long-term survival in vivo in the ab- sence of detrimental pathology ...C2D macrophage cells responded to ...
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Parathyroid hormone and lipopolysaccharide induce murine osteoblast like cells to secrete a cytokine indistinguishable from granulocyte macrophage colony stimulating factor
... unknown cytokines, we have induced primary murine osteoblasts with two bone active agents, parathyroid hormone (PTH) and lipopolysaccharide (LPS) and analyzed the conditioned media (CM) for the presence of specific ...
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Lipoprotein proteoglycan complexes induce continued cholesteryl ester accumulation in foam cells from rabbit atherosclerotic lesions
... inhibition. Foam cells degraded 125I-LDL-proteoglycan complex and 125I-acetyl LDL in a saturable, dose-dependent ...48%. Foam cells degraded 125I-methyl-LDL-proteoglycan complex to the same ...
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