Macrophage inflammatory protein
Antisense inhibition of macrophage inflammatory protein 1 α blocks bone destruction in a model of myeloma bone disease
... Myeloma bone disease is characterized by lytic bone lesions with little or no reactive new bone formation. Up to 80% of multiple myeloma (MM) patients pres- ent with bone pain, and over 70% of the patients will develop ...
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Macrophage Inflammatory Protein 1 Beta (MIP 1β) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis —MIP, MPV and PDW in SBP
... measure macrophage inflammatory protein one beta (MIP-1 β ), mean platelet volume (MPV) and platelet distribution width (PDW) to evaluate their usefulness in the diagnosis of spontaneous bacterial ...
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Original Article Correlation of Macrophage Inflammatory Protein-2 Expression and Brain Edema in Rats after Intracerebral Hemorrhage
... whether inflammatory mediators released from the blood after cerebral hemorrhage plays a role in brain edema, we investigated the dynamic change of the inflammatory mediator macrophage ...
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Human natural killer cells produce abundant macrophage inflammatory protein 1 alpha in response to monocyte derived cytokines
... Once infected by obligate intracellular pathogens, mono- cytes/macrophages release cytokines that activate natural killer (NK) cells. NK cells in turn produce and secrete monocyte/macrophage activating factors ...
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Therapeutic Effect of Anti-Macrophage Inflammatory Protein 2 Antibody on Influenza Virus-Induced Pneumonia in Mice
... We investigated the effect of anti-macrophage inflammatory protein 2 immunoglobulin G (aMIP-2 IgG) on the progression of influenza virus-induced pneumonia in mice. When mice were infected with a ...
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Macrophage inflammatory protein–1α as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions
... in macrophage inflammatory protein–1α (MIP-1α) despite normal numbers of tissue mast cells and no decrease in the levels of allergen- specific ...
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Human eosinophils can express the cytokines tumor necrosis factor alpha and macrophage inflammatory protein 1 alpha
... for macrophage inflammatory protein-1 alpha (MIP-1 alpha) mRNA, whereas eosinophils of normal donors demonstrated only weak or undetectable hybridization signals for MIP-1 alpha ...
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Macrophage inflammatory protein 3α transgene attracts dendritic cells to established murine tumors and suppresses tumor growth
... chemokine, macrophage inflammatory protein 3α (MIP-3α), is chemo- tactic for DCs in vitro, we hypothesized that adenovirus-mediated gene transfer of MIP-3α (ΑdMIP-3α) to tumors might induce local ...
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Increased plasma macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta levels in type 1 Gaucher disease
... that macrophage inflammatory protein (MIP)-1 α and MIP-1 β , both implicated in skeletal complications in multiple myeloma (MM), are significantly elevated in plasma of Gaucher ...
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Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver
... chemokine macrophage inflammatory protein 1α (MIP-1 α ) in virus-infected livers elicits recruitment of activated NK cells to form distinct inflammatory foci around infected cells ...cell ...
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Role for Macrophage Inflammatory Protein 2 (MIP-2), MIP-1α, and Interleukin-1α in the Delayed-Type Hypersensitivity Response to Viral Antigen
... of this response, neutrophils are the most abundant cells at the antigen challenge site both initially and at the peak of the reaction. We investigated what role, if any, neutrophils play in the DTH to a viral antigen. ...
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Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription
... chemokine, macrophage inflammatory protein-2 (MIP-2) appears to play a pivotal role in the induction and perpetuation of inflammation in the ...and protein preceded infiltration of the CNS by ...
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Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis
... The events promoting leukocyte infiltration into sites of in- fection are complex and involve the participation of various factors, including chemokines. Chemokines are a superfamily of more than 30 low-molecular-mass ...
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Macrophage Inflammatory Protein 1α Inhibits Postentry Steps of Human Immunodeficiency Virus Type 1 Infection via Suppression of Intracellular Cyclic AMP
... -chemokines macrophage inflammatory protein 1 ␣ (MIP-1 ␣ ), MIP-1  , and RANTES, interfere with HIV-1 binding to CCR5 receptors and decrease the amount of virions entering ...
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Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK
... Homocysteine-induced MIP- 2 is mediated by p38MAPK and PI3 kinase. MCs were incubated (24 hours; 37°C) in the presence of Hcy (50 μM) with or without inhibitors U0126 (p42/44 MAPK inhibitor; 10 μM), SB203580 (p38MAPK ...
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The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity
... Detergent-resistant membranes from astrocytes were isolated on the basis of their insolubility in Triton X-100 at 4°C and their ability to float in density gradients as described previously [18,19]. Astrocytes were ...
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Macrophage inflammatory protein 1 alpha A novel chemotactic cytokine for macrophages in rheumatoid arthritis
... Burrows, H. L. Evanoff, G. K. Haines, R. M. Pope, and R. M. Strieter. 1991. J. Immunol. 147:2187; Koch, A. E., S. L. Kunkel, L. A. Harlow, B. Johnson, H. L. Evanoff, G. K. Haines, M. D. Burdick, R. M. Pope, and R. M. ...
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Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma
... several inflammatory cytokines, ...these inflammatory cytokines with cancer suggest that changes to a cluster of inflammatory cytokines may be caused by the tumor and could be related to patients’ ...
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Modulation of neutrophil influx in glomerulonephritis in the rat with anti macrophage inflammatory protein 2 (MIP 2) antibody
... Escherichia coli exhibited neutrophil chemotactic activity and produced neutrophil influx when injected into the rat bladder wall. By using a riboprobe derived from the cDNA and an anti-rMIP-2 polyclonal Ab, MIP-2 was ...
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[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production
... regulating autonomic activities within the body, especially during the “fight or flight” response. It is also widely accepted that adrenergic stimulation of the appropriate AR can influence blood pressure, airway ...
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