Major histocompatibility complex class I and II
Binding of Human Cytomegalovirus US2 to Major Histocompatibility Complex Class I and II Proteins Is Not Sufficient for Their Degradation
... class I. Therefore, the surfaces of US2 involved in contacting class I and II differ to some ...bind class I and II appear to be involved in these ...of ...
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Human Cytomegalovirus US2 Causes Similar Effects on Both Major Histocompatibility Complex Class I and II Proteins in Epithelial and Glial Cells
... of class II ␣ exhibited similar levels of degradation of ␣ chain at any given concentration of ...for class I HC over class II ␣ ...and class II ␣ (DR␣) or ...
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Evolution of major histocompatibility complex class I and class II genes in the brown bear
... putative ABS, as inferred from crystallographic models of HLA. These 4 alleles probably represented 2 loci, one of which was not expressed. Our data also suggest the presence of one expressed DQA locus. The rarer of two ...
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The Lytic Cycle of Epstein-Barr Virus Is Associated with Decreased Expression of Cell Surface Major Histocompatibility Complex Class I and Class II Molecules
... MHC class I expression is decreased in the lytic ...MHC class I molecules with antibody W6/32 to HLA-A, -B, and -C, followed by RPE-conjugated anti-IgG2a secondary antibodies, revealed a ...
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The major histocompatibility complex class I immunopeptidome of extracellular vesicles
... distance from the infected cell or main tumour, thus potentially reducing effective CTL responses. The same observation would however also imply that EVs can be used as an effective source to isolate and detect TSA and ...
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Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
... MHC class I ...MHC class II genes, which may in turn be linked to genes that affect MHC class I expression, we studied other autoimmune diseases to determine whether MHC ...
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
... Endogenous peptides presented by MHC-I molecules (called MHC-I peptides (MIPs) or the immunopepti- dome) represent the key to self/non-self-discrimination by cells of the immune system. In this respect, a ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... pathogens. Major histocompatibility complex class I (MHC-I) molecules play a central role in this defense as reporters of cellular content by presenting peptides derived from ...
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Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... MHC I-subversive glycoproteins of MCMV control the MHC I pathway in MEF but fail to downregulate MHC I molecules in infected ...MHC class I molecules differs between cell types as well ...
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Human Cytomegalovirus Protein pp71 Disrupts Major Histocompatibility Complex Class I Cell Surface Expression
... MHC class I or ...MHC class I, CD71, and MHC class II proteins by flow cytometry as described in Ma- terials and ...MHC class I and CD71 values derived from three ...
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Major histocompatibility complex haplotypes and class II genes in
... ABSTRACT Previous studies demonstrated that HLA- DR4 was markedly increased among Ashkenazi Jewish patients with pemphigus vulgaris (PV), almost entirely as the common Jewish extended ha[r] ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... MHC class I protein from the cell membrane but weak enough as to maintain any interactions with ...β2M. I have employed NP-40 and Triton-X based lysis buffers and different protocols with varying ...
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Regulation of major histocompatibility complex class II gene expression in trophoblast cells
... MHC class II expression is activated in mouse trophoblast cells treated with the histone deacety- lase inhibitor trichostatin A (TSA), which is a fungal prod- uct ...MHC class II molecule ...
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Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
... HLA class I ...that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by ...
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Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice.
... We favor the hypothesis that demyelination results from a specific host immune response directed against viral or virally induced antigen on oligodendrocytes or myelin (38). This hy- pothesis envisions a chronic ...
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Impact of Endogenous Intronic Retroviruses on Major Histocompatibility Complex Class II Diversity and Stability
... The major histocompatibility complex (MHC) represents a multigene family that is known to display allelic and gene copy number variations. Primate species such as humans, chimpanzees (Pan ...
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Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
... HLA class II-restricted T-cell ...HLA class II evasion, viral tropism should be ...HLA class II ⫹ host B ...have class II constitutively expressed at high levels, ...
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Genomic organisation and transcript identification in the class II region of the human major histocompatibility complex
... which class I and class II molecules play an important role in determining the specificity of an individuals immune response is through the selection of the T cell repertoire during ...
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Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands
... a major role in regulating immune ...the major histocompatibility complex (MHC) class II ...MHC II molecules, no accurate methods exist to predict which ligands are ...
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Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... of major histocompatibility complex class I heavy ...free class I heavy chains are proximal targets for US2-induced degradation, shortly after their ...of class ...
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