the major species of cytochrome P-450 induced in rat liver by 3-methylcholanthrene
Metabolism of estradiol in liver cell culture Differential responses of C 2 and C 16 oxidations to drugs and other chemicals that induce selective species of cytochrome P 450
... cultures with 3-methylcholanthrene, benzo[a]pyrene, or benz[a]anthracene. The latter chemicals, however, were found to increase the extent of oxidation at C-2 significantly (i.e., 1.5-2.2-fold increases ...
8
Additive Hepatoprotection of Ranitidine with Vitamin E in Rifampicin Induced Hepatotoxicity in Rats
... as cytochrome P-450 content were ...and cytochrome P-450 content in dose related manner but the protection by the combination of ranitidine and vitamin E was additive when ...
14
Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P 450b and P 450e gene expression after phenobarbital
... approximately 20 hepatocytes located between a terminal portal venule and a hepatic venule, PB induced the P-450b,e mRNA up to sixfold in the 12-15 hepatocytes located closer to the hepatic venules (zones 2 ...
10
Purification of a human liver cytochrome P 450 immunochemically related to several cytochromes P 450 purified from untreated rats
... of liver microsomal cytochromes P-450 in rats are four related isozymes (P-450f-i) notable for their lack of ...these rat P-450s. A human liver P-450, termed ...
7
Corvitin modulates the content of lipids in rat liver bile
... the biological role of PLs is diverse, they are of par ticular importance for the liver. First of all, PLs are important components of cellular membrane and bile thustheirdeficiencymaycausedamagetohepato ...
10
The role of reactive oxygen species in tumor cells apoptosis induced by landomycin A
... For analysis of the cytomorphological features of alterations in the target cells under LA action, MG-63 human osteosarcoma cells were stained with fluorescent dye Hoechst 33258 (Fig. 3). Owing to changes in the ...
11
Original Article Hydroxycamptothecin-induced apoptotic gene expression profiling by PCR array in human Tenon’s capsule fibroblasts
... HCPT induced apoptosis in HTCFs in a concentration-and time-dependent ...treatment induced the upregulation of CHOP and downregulation of XIAP in ...HCPT induced the apoptosis of HTCFs, involving the ...
11
The nonerythropoietic component of early bilirubin
... of cytochrome P- 450 synthesis showed a minor increase in early labeling when glycine-2- 14 C but not when delta ALA-4- 14 C was used as ...and cytochrome P-450 synthesis but ...
15
Biodegradation of Caffeine by Trichosporon asahii Isolated from Caffeine Contaminated Soil
... These induced cells were harvested by centrifugation as ...these induced cells were suspended in phosphate buffer, which were used for caffeine degradation ...
10
The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung
... initiation of apoptosis (for a summary see [1-6]). Ellipticine was found (i) to arrest cell cycle progression due to modulation of levels of cyclinB1 and Cdc2, and phosphorylation of Cdc2 in human mammary adenocarcinoma ...
12
Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes
... Background: Chemicals of herbal products may cause unexpected toxicity or adverse effect by the potential for alteration of the activity of CYP450 when co-administered with other drugs. Eleutherococcus senticosus (ES), ...
7
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1
... constructed from HLD8.2 proved to be a specific and sensitive diagnostic reagent. All sera from patients with LKM-1 positive liver disease react with this fusion protein. No reaction was seen, however, for sera ...
8
Intracellular signaling in the regulation of renal Na K ATPase II Role of eicosanoids
... monooxygenase pathway, or by pretreating the animals with CoCl2, which depletes cytochrome P450. Equimolar concentrations (10(-7) M) of the cyclooxygenase inhibitors indomethacin or meclofenamate caused only a ...
8
Hepatoprotective activity of Cyperus articulatus Linn against paracetamol induced hepatotoxicity in rats
... a major role in the management of various liver disorders along with other system associated ...diseases. Liver is a key organ regulating homeostasis within the body by various ...functions. ...
6
Hepato Protective and Antioxidant Activity of Cnidoscolus Phyllacanthus against D- Galactosamine induced oxidative strees in Rats.
... Lipid peroxidation is the introduction of a functional group containing twocatenated oxygen atoms, O-O, into unsaturated fatty acids in a free radical reaction Polyunsaturated fatty acids susceptible to free radical ...
77
CYP11A1 and PCOS susceptibility were examined. Seven SNPs in CYP11A1 were genotyped using the MassARRAY iPLEX platform in 285 PCOS patients and 299 control individuals.
... Polycystic ovary syndrome (PCOS) is a hetero- geneous hormonal disorder affecting a fif- teenth in women, and is one of the most com- mon causes of female infertility. PCOS is a kind of reproductive and metabolic ...
7
Role of cytochrome P 450 in reperfusion injury of the rabbit lung
... fluid. P-450 inhibitors also prevented the increase in lung tissue levels of thiobarbituric acid reactive products in the ...model. P-450 inhibitors did not block enhanced ...
9
A REVIEW ON GENETIC POLYMORPHISM OF CYTOCHROME P-450 2C19 AND ITS CLINICAL VALIDITY
... Individual response to a drug is governed by many factors such as genetics, age, gender, environment and disease. The influence of genetic factors on the response of a drug is a known fact. Study of the influence of ...
6
AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)
... Fig. 2 AHR and GPER are involved in the activation of the EGFR/ERK1/2/c-Fos transduction pathway by 3MC. Phosphorylation of EGFR (a, c) and ERK1/2 (b, d) in SkBr3 cells and CAFs treated for 15 min with vehicle ( − ) or 1 ...
18
Role of Cytochrome P 450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs
... Cytochrome P-450 (C-P450) is found in the lung and may modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical ...
9